Protein
Enoyl-[acyl-carrier-protein] reductase 2, mitochondrial
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Function
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.
Similarity
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Sequence
MYRNQLARASLRSTSSINQIRNMITAQAVVYAQHGEPKDVLKTLKYEIDDDNLDSNSIIVKTLGSPVNPSDINQIQGVYPSKPEKTTELGSNEPVAVCGNEGLFEILKVGDNVSNFKVGDWCVPTSVNMGTWRTHMLCGGDEMTKIPNPEQSKANGKPSGLSVNQGATISVNPLTAYLMLTHYVKLTPGKDWFIQNGGNSAVGKYATQISNLLGINSISVIRDRPDLQDLIKNMTEECGATKVITEEQNASKEFGSEIKSWVKETGGEIKLALNCVGGKNSTGIARKLNNNGLMLTYGGMSMQPVILPTSLHIFKNITSSGFWVTQLLKNDVELKRKTLGQIIEWYENRQLKDAPSKETKFNPSDELSRYYIDGIVNSKGGKQLIVY