ERG1

Gene

ERG1

Protein

Squalene monooxygenase

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)

Length

497 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

55.153 kDa

Sequence

MSKETSYPKELLCADEKVVYDAIVVGAGVVGPCVATALARKGKKVLIVEREWSQPDRIVGELMQPAGVRALRSLGMVQAINNIDACSTSGYTVIYNGEKISFAYPYKADLSPPEKIPDLVFDGNDKVVDDGTISAKEFEEDEREHGVGFVHGRFLQNLRAICAAEDRVTRLQGNVISILRNDSKEVIGAKVDVPGRGKVDFKAHMTFVCDGIFSRFRKELSTTNTSKVWSSFVGLSLHHADLPTKHHGHVILGSEHMPVIAYQISSTETRILCAYNYPTLPKNVPEWLQKEVQPFIPPSLRKSFDAALESKSYKCMPNSWLPASQNNVTGLCVVGDALNMRHPLTGGGMAVGLMDVVLLVKTIGDMDFSDREEVLNELLGFHYERKAHACVINTLSIALYSLFAADSYYLKKLQKGCFEYLGRGEDWVRQPISFLSGVLPSPYLLTKVFFTVALYSVLINFRGRTPLGFLLAIYEGFAIIFTAAKVFTPFLYEQLLQ

Protein

Squalene monooxygenase: ERG1

Gene

ERG1

Protein

Squalene monooxygenase

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)

Length

497 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

55.153 kDa

Sequence

Protein

Squalene monooxygenase: ERG1

Gene

ERG1

Protein

Squalene monooxygenase

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

496 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

55.298 kDa

Sequence

MSSVKYDAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALRELGMIKAINNIRAVDCTGYYIKYYDETITIPYPLKKDACITNPVKPVPDAVDGVNDKLDSDSTLNVDDWDFDERVRGAAFHHGDFLMNLRQICRDEPNVTAVEATVTKILRDPSDPNTVIGVQTKQPSGTVDYHAKLTISCDGIYSKFRKELSPTNVPTIGSYFIGLYLKNAELPAKGKGHVLLGGHAPALIYSVSPTETRVLCVYVSSKPPSAANDAVYKYLRDNILPAIPKETVPAFKEALEERKFRIMPNQYLSAMKQGSENHKGFILLGDSLNMRHPLTGGGMTVGLNDSVLLAKLLHPKFVEDFDDHQLIAKRLKTFHRKRKNLDAVINTLSISLYSLFAADKKPLRILRNGCFKYFQRGGECVNGPIGLLSGMLPFPMLLFNHFFSVAFYSVYLNFIERGLLGFPLALFEAFEVLFTAIVIFTPYLWNEIVR

Protein

Squalene monooxygenase: ERG1

Gene

ERG1

Protein

Squalene monooxygenase

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

496 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

55.298 kDa

Sequence

Protein

Squalene monooxygenase: ERG1

Gene

ERG1

Protein

Squalene monooxygenase

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

496 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

55.126 kDa

Sequence

MSAVNVAPELINADNTITYDAIVIGAGVIGPCVATGLARKGKKVLIVERDWAMPDRIVGELMQPGGVRALRSLGMIQSINNIEAYPVTGYTVFFNGEQVDIPYPYKADIPKVEKLKDLVKDGNDKVLEDSTIHIKDYEDDERERGVAFVHGRFLNNLRNITAQEPNVTRVQGNCIEILKDEKNEVVGAKVDIDGRGKVEFKAHLTFICDGIFSRFRKELHPDHVPTVGSSFVGMSLFNAKNPAPMHGHVILGSDHMPILVYQISPEETRILCAYNSPKVPADIKSWMIKDVQPFIPKSLRPSFDEAVSQGKFRAMPNSYLPARQNDVTGMCVIGDALNMRHPLTGGGMTVGLHDVVLLIKKIGDLDFSDREKVLDELLDYHFERKSYDSVINVLSVALYSLFAADSDNLKALQKGCFKYFQRGGDCVNKPVEFLSGVLPKPLQLTRVFFAVAFYTIYLNMEERGFLGLPMALLEGIMILITAIRVFTPFLFGELIG

Protein

Squalene monooxygenase: ERG1

Gene

ERG1

Protein

Squalene monooxygenase

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)

Length

489 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

54.492 kDa

Sequence

MSLTNADETVTYDALIVGAGVIGPCVATALARKGKKVLIVEREWSQPDRIVGELMQPGGLRALRSLGMIQSINNIDAYPVTGYTVFYNGEHVDIPYPYKADLKPVEKLPGLVRDGNDKVLEDATVHKKDFEDDERERGVGLVHGRFLNNLRNICAAEPNVTRLQGNVVEILKDKKNEVVGAKVDVDSRGKVDFKAHLTFVCDGIFSRFRRELHPDHVPTVNSSFVGMSLYHAHMPHDMHGHVILGDKHMPILVYQISPEETRILCAYNAPKVPTDLKSWMTKDVQPYIPKTLRPSFDDALAQGKFKPMANSWLPARQNDVTGLCVIGDALNMRHPLTGGGMTVGLNDVVLLIKKIGDLDFSDREKVLDELLDYHFERKNYDAVVNVLSISLYSLFAADSKNLKALQKGCFKYFQRGGDCVNLPVAFLAGVLPKPLLLTRVFFAVAFYTIYLNMEERGFLGLPMALLEGIMILITAIKVFTPFLVRELIG

Protein

Squalene monooxygenase: ERG1

Gene

ERG1

Protein

Squalene monooxygenase

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)

Length

489 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

54.492 kDa

Sequence

Protein

Squalene monooxygenase: ERG1

Gene

erg1

Protein

Probable squalene monooxygenase

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

457 amino acids

Function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Similarity

Belongs to the squalene monooxygenase family.

Mass

50.339 kDa

Sequence

MATQDADIIIIGAGITGCALGAALGRQGRKVLVLERDMSEPDRIVGELLQPGGIEALEKIGIADAVEGIDGQWTSGYQIFYGDSNVSVPYPSKPNGGAYQGIGFHYGRFVMNLRKALTSTPNVTVTEATVNELLRDETGEVITGVVTSSKKSESPVEYKAPLTIVCDGCFSKFRKAFIDHPIQVTDHFLGLILTNPDYIAPGRGHVILSKVAPMVLYPISSTEARILINYPGKNLPPMETLKKYVLESCVPNMPEKLRPSLKAAVYNDRLRSMPNQFLPPTVNRTKGMILVGDSNNMRHPLTGGGMTVCFHDAYLLSRFISPSAVPDLLDYERILNQMNKFHWKRKGYSFVINVLSIALYKLFTPKNRYMKALESGCIDYFKRGGNCVEGPIRLLGGLDHSPSHLIGHFYAVCLYGIYQYVLSGPALLMPVRIIESLLIFLQASLVIIPYILSEMSS

Protein

Probable squalene monooxygenase: erg1

Gene

ERG1

Protein

Elicitor-responsive protein 1

Organism

Oryza sativa subsp. indica

Length

159 amino acids

Function

May play a role in plant defense signaling. Isoform 2 binds to phospholipids in a Ca(2+)-dependent manner in response to pathogen elicitors.

Mass

17.736 kDa

Sequence

MAGSGVLEVHLVDAKGLTGNDFLGEIGKIDPYVVVQYRSQERKSSVARDQGKNPSWNEVFKFQINSTAATGQHKLFLRLMDHDTFSRDDFLGEATINVTDLISLGMEHGTWEMSESKHRVVLADKTYHGEIRVSLTFTASAKAQDHAEQVGGWAHSFRQ

Protein

Elicitor-responsive protein 1: ERG1

Gene

ERG1

Protein

Elicitor-responsive protein 1

Organism

Oryza sativa subsp. japonica

Length

159 amino acids

Function

May play a role in plant defense signaling (Probable). Isoform 2 binds to phospholipids in a Ca(2+)-dependent manner in response to pathogen elicitors (PubMed:14529272).

Mass

17.736 kDa

Sequence

MAGSGVLEVHLVDAKGLTGNDFLGEIGKIDPYVVVQYRSQERKSSVARDQGKNPSWNEVFKFQINSTAATGQHKLFLRLMDHDTFSRDDFLGEATINVTDLISLGMEHGTWEMSESKHRVVLADKTYHGEIRVSLTFTASAKAQDHAEQVGGWAHSFRQ

Protein

Elicitor-responsive protein 1: ERG1