Protein
ER lumen protein-retaining receptor
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes H-D-E-L and D-D-E-L, but not K-D-E-L.
Similarity
Belongs to the ERD2 family.
Sequence
MLNVFRIAGDFSHLASIIILIQSITTSNSVDGISLKTQLLYTLVFITRYLNLFTKWTSLYNFLMKIVFISSSVYVIVLMRQQKFKNPVAYQDMITRDQFKIKFLIVPCILLGLIFNYRFSFIQICWSFSLWLESVAILPQLFMLTKTGKAKQLTSHYIFALGLYRALYIPNWIWRYYTEERFDKLSVFTGVIQTLVYSDFFYIYYQKVIKLGGDLELPQ