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ERCC6L

Gene
ercc6l
Protein
DNA excision repair protein ERCC-6-like
Organism
Danio rerio
Length
1451 amino acids
Function
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Similarity
Belongs to the SNF2/RAD54 helicase family.
Mass
163.227 kDa
Sequence
MESNNVEEVTDKFGGCLSLDTEKMGKYDRYRQKGKEAALNGELPRALELFQLAYQLQPSEKLKKRIQAIQDLIQREDEEDEEEEEEFVNVNNSGLKLYKGLYDKLYDHQKEGVAFLYSLYRDGRKGGILADDMGLGKTIQVISFLSGMYDAELANHTLLVMPTSLIKNWVREFAKWTPGMRVKEFHGSSKTERNRNLERIQRKGGVIITTYQMLINNYEQLGSNGHREFKWDYVILDEAHKIKTSSTKTAKSAHAIPAKNRVLLTGTPVQNNLREMWALFDFACQGSLLGTSKTFKTEYENPITRAREKDATPGEKALGLRISQNLTDIIKPYFLRRTKADVQQKKLKLEEGFEEEEDQENKCPNAREGVEMPSLTRKNDLIVWTYLSSVQEDIYNKFISLDQIKELLTTTRSPLAELTVLKKLCDHPRLLSQRAVIQLGLERGSDSELVHSDESESAVSQIDNISDHTLIEESGKLQFVVSLMECLREEGHRTLIFSQSRKMLDIMERVLRNRNFRLLRLDGTVTQLAEREKRISLFQTDKRYTIFLLTTQVGGVGITLTGANRVVIFDPSWNPATDAQAVDRAYRIGQTENVIIYRLITCGTVEEKIYRRQVFKDSLIRQTTGDKKNPFRYFSKQELRELFKLEDTRSSSTQQQLQAMHAQSRRSDTSLDHHIARLHSMEMFGISDHDLMFTKEPAADEDDPEDAESHHYIQTRVQKAQELMQAESELHGQLLDSMAQNTEPAWLRQMGQPNSSIRDRPAPPRIKNEPVTVDLTHNSFDEPEFEEDEQNLPSAEDAEMETASEDVEVIGDEDLGDKVISSEVEVVGEEVEVVAEEVEDAGEVEVVSEEVEGVGVEVEDVGVEVEDAGVEVEDAGVEVEDAGVEVEDAGEVEVVSGEGQVQPKSPQSGGEWNLQIVKTEVSPIAEKFADVITLDDTSDEADSSDFNTESKQQNSSQRFQSPSLQFPKLDDLSGASNTLGNEEVEPEKCHSQVLSSPLSQHEATTDEPFKAEMEMPHGNFNLLLEDSADMYFPEDEEVHEVEESAAEESPEFQLQMDVSGERLEEPSINHDKQNNGEFVNYNDSEVSKRESLLKIRSTPNESVDDSFVHSVRTKKRQVISDTEEEEEEEEESEKPCLTSSPFIDAISRLGSSTPKAVLVDGARLRRSLNASVASRRSFVVSLLENESDEESNEDKTKSSGASETCADELVEEVQTSSGDNSKSYETSEANGTLADELVEEEGEYREGKNTSDKVSESNETHSEEFAEEEKPSGDKSESYEISEASETHTDNSEEEIIGDHTGSYKISESSEADESVVEEEEPSGETLNTEESEMGEEEESAELIAGQEQEEWHSAVLESTGDVELDSNETMDQCAPKTVPVETHVLPVSSTNTAAEASDNKYNLLVLSGKQSLAEGRKQEALDFFLKAIDINTGDPEIQLLIIQLYRQLSQ

Gene
ERCC6L
Protein
DNA excision repair protein ERCC-6-like
Organism
Homo sapiens
Length
1250 amino acids
Function
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin (PubMed:17218258). Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328).
Similarity
Belongs to the SNF2/RAD54 helicase family.
Mass
141.103 kDa
Sequence
MEASRRFPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQKIQEALEELAEQGDDEFTDVCNSGLLLYRELHNQLFEHQKEGIAFLYSLYRDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGPSKDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKSAICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPSLSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACCLLNLGTFSAQDGNEGEDSPDVDHIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQTLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAAQRKSDIKLDEHIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQNKEFLMEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMASVVIDDLPKEGEKQDLSSIKVNVTTLQDGKGTGSADSIATLPKGFGSVEELCTNSSLGMEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN

Gene
ERCC6L
Protein
DNA excision repair protein ERCC-6-like
Organism
Bos taurus
Length
1242 amino acids
Function
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Similarity
Belongs to the SNF2/RAD54 helicase family.
Mass
140.51 kDa
Sequence
MEVSRGFAEAGALSPEQAASYLRYVKEAKEATKNGDLEQALKLFNLAKDIFPNEKVMSRIQKIQEALEELAEHGDDEFIDVCNSGLLLYQELHNQLYEYQKEGIAFLYSLYRDGRRGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTSLISTWLREFVKWTPGMRVKTFHGPSKDERTRNLCRIQQRNGVIITTYQMLINNWQQLSSLNGQEFLWDYVILDEAHKIKSSSTKSAICARAIPASNRILLTGTPIQNNLQELWSLFDFACQGSLLGTLRTFKMEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEEVQKKKSSNPEVQLSEKSPDVGAICEMPSLSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACGLLNLGAAKFSVQDEIEGEDSSDVDHIDQISDDTLMEESGKMLFLMDLLKKLRDEGHQTLVFSQSRRILNIIERLLKNRHFKILRIDGTITHLVEREKRISLFQQNKDYSVFLLTTQVGGVGLTLTAASRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGDKKNPFRYFSKQELRELFTIEDFQNSATQLQLQSLHAAQRRSDKNLDEHIAFLHSLRIAGISDHDLMYTRDLSVKEELDVIEDSHYIQQRVQKAQFLVESESQNTELLMERQKMGNEGIWLREPVYQTKKKRPKVNKPQPQPSSHLPVYHTQEEISSLMASIIIDDLPKEDEKDLSRIKLNDTIPQDGRHPCVITLNDDFVTTLPKGCGDVEEIFPDSLSGMALQKEASQEGFMQESEQESPLASFNYLPSKSARVDLGPNLDQLEDDEVLHHCNPSPANPKTKEYQRPESNVSVIKIADDDLTAAHSALQDAQANEAKLEEEPLASSGQYACDFNLFLEDSADNGQNLSSQFLEHVEKENSLCGSAANSRAESVHSKACLSVDLSEEDDEPEEVVNVKIRRKARRIDSDNEDEHTFKDTSSTNPFNTSPFPFLSVKQFDASTPKNDISLPERFFSPKISDSINKSVNSRRSLASRRSLINVVLDHVEDMEERLDNSSEAKVVEDHLEEGAEESGDEAPEHTKEDPSRETLSSENKSSQLSTSKPGALAQETSPGDPEPLSDGQLVDSPQDEAMEAVNDYDTLVLHGKELKECGKIQEALDCLVKALDIKSSDPEVMLMTLSLYKQLNKT

Gene
Ercc6l
Protein
DNA excision repair protein ERCC-6-like
Organism
Mus musculus
Length
1240 amino acids
Function
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Similarity
Belongs to the SNF2/RAD54 helicase family.
Mass
138.854 kDa
Sequence
MEASQGLAEVETLSPQLAESYLRYVQEAKEAAKNGDLEESLKLFNLAKDIFPTKKVMSRIQKLQEALEQLAEEEDDDEFIDVCSSGLLLYRELYEKLFEHQKEGIAFLYSLYKDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVNEFAKWTPGMRVKTFHGSSKSERTRSLTRIQQRNGVVITTYQMLLNNWQQLASFNGQAFVWDYVILDEAHKIKSASTKSAVCARAIPASNRLLLTGTPVQNNLQELWSLFDFACQGSLLGTLKTFKMEYEHPIIRAREKDATPGEKALGLKISENLMEIIKPYFLRRTKEEVQTKKADNPEARLGEKNPAGEAICDMFSLARKNDLIVWIRLLPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACRLLNLGTATFSAQDENEQEDVSNMNSIDHLPDKTLIQESGKMIFLMSLLERLQDEGHQTLVFSQSIKILNIIERLLKNKHFKTLRIDGTVTHLWEREKRIQLFQQNKEYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFTKQELKELFTVGDLQKSATQMQLQCLHAAQRRSDEKLDEHIAYLHLLGIAGISDHDLMFTRDLSVKEELDMLEDSQYIHQRVQKAQFLVESESQNTVQRQTTGIEETWLKAQEFPSQQKKKGTEFNKPQPQPSRLLTKPTQVEAISSQMASITICDQSAESEPQEHSEVHDVTSLQGSHHFNSTSDAGTIASLPQGAESIGEVSTDSLLSPAKGFAAENDAMQKKGLQASPGQEAPSENLGSFHYLPRESSKASLGPNLDLQDSVVLYHRSPTANENQNLESDVPMIEISDDLSEPPSALQGAQAIEAQLELKEDDPLKSPPQYACDFNLFLEDSADTRQNLSSKFLEHVEKEKSLQSPAANSRAKSALTLSLDSSPKSDEESEVISVKTKSKTRRILSDDEDEDEEDAFKGSHTNSINISPFPFSSVKQFDASTPQSGSNPSRRFFSPKTPGEVNTSLHSRRSLASRRSLINVVLDDVEDMEERLDNSSEEESEPGLSEENNEEEALACTEEQPSGATLASGNKSSNLTMSEPTSPAPQSSPCAPEPSSSDPMPDPPQDLAVEAGNDYESLVARGKELKECGKIQEALNCLVKALDIKSADPEVMLMTLSLYKQLNI