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ERAP2

Gene
ERAP2
Protein
Endoplasmic reticulum aminopeptidase 2
Organism
Homo sapiens
Length
960 amino acids
Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Similarity
Belongs to the peptidase M1 family.
Mass
110.462 kDa
Sequence
MFHSSAMVNSHRKPMFNIHRGFYCLTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT

Gene
ERAP2
Protein
Endoplasmic reticulum aminopeptidase 2
Organism
Pongo abelii
Length
960 amino acids
Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity).
Similarity
Belongs to the peptidase M1 family.
Mass
110.256 kDa
Sequence
MLHSSAMVNSHRKSMFNIHKGFYCLAAILPQICICSQFSVPSSYHFSEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPAHQQIALLVPEKLMPHLKYYVAIDFQAKLGDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESGHIALSNMPKVRTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSVSGITSSGVKVSIYASPDKQNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFASGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQFDDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLTFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTHYLQHETSSPALLEGLSYLELFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDEGSVWDRMLRSALLKLACDLNHAPCIQKATELFSQWMESSGKLNIPTDVLKIVYSVGAQTAAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHVIARRPKGQQLAWDFVRENWTHLLKKFDLGSFDIRMIISGTTARFSSKDKLQEVKLFFESLEAQGSHLDIFQIVLETITKNIKWLEKNLPTLRTWLLVNT

Gene
ERAP2
Protein
Endoplasmic reticulum aminopeptidase 2
Organism
Bos taurus
Length
954 amino acids
Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys (By similarity).
Similarity
Belongs to the peptidase M1 family.
Mass
109.719 kDa
Sequence
MANSCRKLIFNIYVVFYCSAVIMPQICICSQFTSSPIDQFNKDPKAFPVATNGEIFPWHELRLPTVVIPLHYDLLIHPNLTSLDFVASEKIEVLVRDATQFIILHSKDLEILNASLQSEEDVRYKKPGENLTVLSYPAHQQIALLVPEKLRAHLRYSVAIDFQAKLADGFEGFYKSTYRTLGGETRTIAVTDFEPTEARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDHFETTVRMSTYLVAYIVCDFTSVSGTASSGVKVSIYASPDKWSQTHYALEASVKLLDFYENYFDIHYPLPKLDLVAIPDFASGAMENWGLITYRETSLLFDPKTSSTSDKLWVTKVIAHELAHQWFGNLVTMEWWNDIWLNEGFARYMELISLNITYPELQFDDSFSNTCFEVIKRDSLNSSHPISNEAKTATQIKEMFDAVSYNKGACILNMLKDFLSEETFRKGIIHYLKKFTYRNAKNDDLWHSLSNNCLEGDSTSGGFCYSDSRKTSNTLAFLRENVELKEMMATWTLQKGIPLVVVKREGRSLRLQQERFLSGVFKEDPEWGTLQERYLWHIPVTYSTSSSQAIHRHILKLKTDTVDLSEKTDWVKFNVDSSGYYIVHYEGQGWDELITLLNQNHTLLRPKDRLGLIHDAFQLVSAGRLTLDKALDLTRYLQHETSIPALLKGLEYLELFYRMVERRNISDVTENLKHYLLQYFKPVIDTQSWLDEGSVWDRMLRSTVLKLACYLNHAPCIQKATELFSQWMESSGKLNIPADVLTIVYSVGAQTTAGWNYLLEQYELSLSGAEKNKILYALSTSKHQEKLMKLIELGMEGKVIKTQDLATLLFTTARNPKGQQLAWNFVKENWTHLLKKFELGSFPIRMIISGTTSHFSSKDELQEVKLFFESLKAQGSHLDIFQIILETISKNIKWLEKNLPTLRKWLLTSI