EP400

E1A-binding protein p400

3159 amino acids

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.

343.489 kDa

MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQLMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQSPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGVLLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPEMAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQPFQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCPGDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAELLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNILLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATTQGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTPGAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ

Ep400

E1A-binding protein p400

3072 amino acids

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity). Regulates transcriptional activity of ZNF42.

Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.

337.18 kDa

MHHGSGPQNVQHQLQRSRSFTGSEEEQPAHPNLPPSPAAPFAPSASPSAPQSPGYQIQQLMSRSPVAGQNVNITLQNVGPVVGGNQQITLAPLPLPNPTSPGFQFGAQQRRFEHGSPSYIQVTSPMSQQVQTQSPTQPSPGPGQTLQNVRAGAPGPGLGICSNSPTGGFVDASVLVRQISLSPSSGGHFVFQEAPGLTQMAQGAQVQLQHSGAPITVRERRLSQPHAQSGGTIHHLGPQSPAAAGGTGLQPLASPNHITTASLPPQISSIIQGQLIQQQQQVLQGQPMNRSLGFERTPGVLLPGVGGPSAFGMTSPPPPTSPSRTTMPPGLSSVPLTSMGSSGMKKVPKKLEEIPPASQEMAQMRKQCLDYHYKEMEALKEVFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEGKSEVINDEVKVVTGKDGQTGTPVAIATQLPPNVSAAFSSQQQPFQHQSLTGSLVVGPGSATEADPFKRQQVMPPTEQSKRPRLEVGHPGVVFQHPGVNAGVPLQQLMPTVQGGMPPTPQATQLTGQKQSQQQYDPSTGPPVQNAASLHTPPPQLPARLPPASVPATALPSTLQFSQQSQMVEASTQLQIPVKTQQLNAPIPAPLPSQLPAPSSQPAQPALHVPMPGKAQMQTSQLSSQTQTVASTRPPLDSAQPCQRSLPTSSSSSSLVPVSGSGPGPSPARSSPVNRPSSATNKALSPITSRSPGVAVSAPPKPQSPAQNAASSQDGSQDKLAEQITLENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKLAAAKKLVRTVARHHEEKKLREERGKKEEQSRLRRIAATTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRRGKESRLKGFDTSPEHSLDLGISGRKRKASTSLTDDEVEDEEETIEEEEAHEGLVDHHTELTNLAKEAELPLIDLMKLYEGAFLPNFQWPQPEPDHEESSGEEDVEDCPSDRESRRDSVLIDSLFIMDQFKAAERMSIGKSNTKDITEVTAVAEAILPKGSARVTTAVKFSAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVVMRSCNILKWELELKRWCPGLKTLSYVGSHRELKAKRQEWTEPNNFHICITSYKQFFRGYTAFSRVHWKCLVVDEMQRVKGMTERHWEAIFKLQSQQRLLLIDVPLHNTFLELWTMVHFLIPGISRPYLSFPLKAPNEENQDYYHKMVIRLHRVTQPFILRRTKRDVEKQLTRKYEHVLKCRLSSRQKALYEDVILQPRTQEALKSGHFVSVLSVLTRLQRICNHPGLVEPRVPGSSFAAGSLQYKSASLILRVLEREFWKETDLSIFDLIGLENKITRHEAELLCKKKVTRKLMEEVFASPPPSARPAAVKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRMANTNTSTATPQGQVRGRPPIATFSANPDTKGGEVVKIAQLASIAGPQSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHSTLGSKPPTSGPSPAPLTPQVGVPGRVAVSAMAVGEPGLASKPASPAAGPTQEEKSRLLKERLDQIHFINERRCSQAPVYGRDLLRICSLPGRRKRPLCWSLDSNFGKGPKGVNYDMSLSKSEGDLILTLSQESLQDVLGRVACVIPPVVATPPSLWVARPPSLYSSRLRALRQCLREHTGPYHRQLQQLTALRSLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYVRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDTGFPVKAEEFVVLSQEPSVSETIAPKIARPFIEALKSIECLEEDAQRSTEEAVPGSSSVAVSSDSDGSRYDEEPSQLEELADFMEQLTPIEKYALNYLELFHTTTEQEKERISEDLVMASMKDWETRNARALQEREARLQLEQEEAELLTYTREDAYTMEYVYEDADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGMLKIRREGKEQKKNLLLKQQTPFAKPLPTYVKSSGEPAQDSPDWLIGEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQLYTSHFELMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPPVTQPPPQQQQQQQQQQQQQQQQQQPPPPPQQPPPPVPQPQAASSQTPAGQPAVQPQPQPQVQTQPQPVQPQSKGQPTMTTVGSAAVLAGTIKTSVTGTSIPTGTVSGNVIVNTIAGVPAATFQSINKRLASPVAPGTLTTSGGSAPAQVVHTQQRAVGSPATATTDLVSMTTTQGVRAVTSVTASAVVTTNLTPVQTPTRSLVTQVSQATGVQLPGKTITPAAHFQLLRQQQQQQQQQQQQQQTSQVQVPQLQSQAQSPAQIKAVSKLGPEHIIKMQKQKMQLPPQPPPPQAQPGPPQQPAQVQVQTPQPPQQQQSPQLTTVTAPRPGALLTGTTVTNLQVARLTRVPTSQLQAQGQMQTQTPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKTAGQTVVAQPVNVQQLLKYKQQTAVQQQKAIQPQVAQGQAAVQQKLTTQQITTQGPQQKVAYAAQPALKTQFLTTPISQAQKLAGTQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVTLTQATAAGQQVQMIPTVTATAQLVQQKLIQQQVVTTASASLQTPGGPSPAQLPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ