Protein
E3 ubiquitin-protein ligase ICP0
Organism
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker)
Function
Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100.
Sequence
MGCTVSRRRTTTAEASSAWGIFGFYRPRSPSPPPQRLSLPLTVMDCPICLDVAATEAQTLPCMHKFCLDCIQRWTLTSTACPLCNARVTSILHHVDSDASFVETPVEGATDVDGEEDEPVGGGFAVIWGEDYTEEVRHEEAEGQGSGSGSRARPRVPVFNWLYGQVSTVIESDPIREAVVDNIVEIIQEHGMNRQRVTEAMLPMFGANTHALVDTLFDISAQWMRRMQRRAPMSHQGVNYIDTSESEAHSDSEVSSPDEEDSGASSSGVHTEDLTEASESADDQRPAPRRSPRRARRAAVLRREQRRTRCLRRGRTGGQAQGETPEAPSSGEGSSAQHGASGAGAGPGSANTAASARSSPSSSPSSSMRRPSPSASAPETAAPRGGPPASSSSGSPRSATIFIDLTQDDD