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EME1

Gene
eme1
Protein
Crossover junction endonuclease eme1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
735 amino acids
Function
Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Similarity
Belongs to the EME1/MMS4 family.
Mass
82.574 kDa
Sequence
MTLQSTDSAIVIDSEADVDISSSQASPSKDNIALSEHNVITVLDTPQRSTQCDSLLKSFSTPLVSGSEDVLPSPRDALNITNKKSVTDNLLLSLTSSNQSTNTNLNPSSRVEIINLNSSPPNSLSSQPKHQEFHLFHTPTIPRTTQLSSKTSSPIVIPDDNEQVASPLSKKAASLTSSPLKDFQSSPPLSTVLQKSHSLHDILLDTNDDDHFPFTQSPLTKTKSFNDALTSSSSILKPCMPSIASPTSNRLSHAPSTPNLFPNQDSSNTIDLINNRSKTSVENQERTFNLTSDVHLDSPTSPSKHSSIEPNTSQEDSFQELPSLNKLSIQSRAFKKMRLPKISRTTDTPPASTSNSNKKNLDKLKKMRKLCSRSLEPYELDSNTQRKRKRYEDSLKKSKTLDKVDSLNRKMAKELDRKNSKELQKINKVKRTKEECLSEIILLSPDDWASSWYSTVRSQLDSYNCQFVVNSNQPKDSIMWKRKVNNVFNSSTNRFELSIEHEQIEPFALLRLKCRDFIKYIEEDQADTFFHEMSEKFKGCKLILLLEGIPNYFKSLKAELNRQYAAAVNSGTRPLLFGSLSKYQNFTKEKLESEIVRFSFEHSILINTSNDEKETAQWIVSFTGDIALSRYKHFSKFSARASTTEIGHVKSADRIENSLNFMLRQILRVTPNIANAICDQFDSIPSLIHHLKTHGEESLTNVVIQSSISERNLGPVLSRRIYNTFLCKEASSDAP

Gene
EME1
Protein
Crossover junction endonuclease EME1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
714 amino acids
Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the EME1/MMS4 family.
Mass
79.362 kDa
Sequence
MKSIELIDIESIASDRAGITREDGVIELLSEADEALGRRPYPSSPTIRSTEANIDESIGNRQLWLQSIELNGEFQEDDSEEVEETIGKKPDDALVCSDACSAPDVSIQELLQTFTPPKPHAGRVMKAGAGPVRGSSRQTSSKLQTKDVLQDILVELDDNLSSWDTPSTSGIRSPETVATLAAKWANKTEKTSGKPLYGRPRSSGNRGNILLKRTLANRNNILSSELGGESSPSLQALTTPLPAKSNDGDKNQTTNVMTTGGFRLGTMEKQTLNGSACVDRIQQVPVSSPESVSFLEGLSDIPISKPVQLTQRCIAATNTGYTKDNCASTPRSAAAVEYLEPIDTDTSILSTAGEALPHSPVKPSKVSRERSKRDYIVHSKAFTAEESKAKIRQLMSNTALKKQFNEVNKVTREKQSLLAEIVLSINEQVHQYLLEQKVPIAEVLGPTTVIHNFESVPIIRFKRKCTSMYDLNNDIYYPCETTMCNEPICLLFYNAVDFFTKYKNQKQRLYSEVQDLKRAGNKVIIILNEYSRLEKSLAELENRCMRSRVEQQLTGDKSPRRKTVKEVQLTALEMNSKDLGRKVNEMIIKCDIDIFPINSAASFANWISNLVWVVAKMRYDPMMKNVNWSHINVKIGKTPTEVLSKTLQQINGVTEIRAGRVTSTYPSFQQIFTDFEKGYLVAGKDGNPLMTKVAEKAMNALLMSEDPEEQIYIN

Gene
EME1
Protein
Crossover junction endonuclease EME1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
690 amino acids
Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the EME1/MMS4 family.
Mass
79.008 kDa
Sequence
MDEVNIIDINDTTEQSLVGNEGTANGVVVLISSEGEREGPPASDPIHYSLARSLSDSVGQRNVEDDDVVLLENSVSVSFSLEVEGRFQNDTAIESDNEPASQPQTQTFKRSQSRLLDEIENSGLSISALSDDEEASPLVSNQRSVIHKNIESEVKSGKYIIPLPQSSPLEKMSQVFNYQLASSPTPNKSPSSRSTLPVKSPLQLSTTVANKRSYREVQPPKFDPYLTRKLKKPQNKATADVSSVALDLTKYMEDCHDLYGTLVSDTHIRQQRSLDTKTNSYHSESNYEHDSIVIESDEDDDITNTRQEKPLFVQHSSQSTPVSSNKLALRQPRHVEDEKIDKVKPMVNARPFTDQEYSEMVKKCLGTSEMRKLYNECNKVSRTEETIYNEMILTVNNKVMELIHSKHISFEEELKPLTIIQNYEEFPIIRFKRKCRSIYDQTHGVFYPCDEVIANESICVLVYEALPFFHRYRTDKRGLWDEIRQFSKNGMKVIVVMYGLNALRKKLCNMENRQHEDRVLEQLSGSASSQSQSKTRRRSTQETKMRELNIKSKNLDRIINEVTIYANVDVFPIENLNEFSHWMKNLVWVVGKMRYDVSVKYKEWSHLNVKSGKSPTDVLYSFLQQVAHVNEPKAKRVVTHYKSFQSMMNDMKAGYVAQSHDNKPLMPKSLERALHTLYTSDDPNELIFTD

Gene
EME1
Protein
Crossover junction endonuclease EME1
Organism
Oryza sativa subsp. japonica
Length
650 amino acids
Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference (By similarity).
Similarity
Belongs to the EME1/MMS4 family.
Mass
71.743 kDa
Sequence
MASHAAVVEIIDDDDDDDDDVAAASTPPALHKRSHAVAAAAPDSPDAFSPSPPDPKRRQLAASTIVLDDTPTPPKRRPPPVAADRSASVVADTPRSFVPCSLRNRAIAGDTPDSVLPSPSFHLDAPDSATPGSDVPCSVGLDDIVPETPGFNSPRLARPPAVPGLTSPMTARKFSGVSCPISLDSDDELDDTVYRESLTRTPSNMAKPEHAIQPCTTSCTDKVENTKSTDKKDYSKSNVGYQTNNSACKNNGTTSYNQPPRANSPCEDSTLKEADPFINNHCPQEENALPIEERKKKQQEEKRLKKEKKAREIEEKKQKRLETKKQKEAMKAELAELKKLEKEKKKWESGKLATKCIVAEIDSSVIESGSVGGHLVQGFHEKGLCFRVTSNSIKGSILWKMQIPNEFTQDQASTSQVPYILFVLQAEEFCDLVSGGTLLDHVQKVRRQYPEFTICYVTNKLMSFIKRREQNQYNKTTSNSNSWKRPPVEEALCKLATHYARVRSRHCTDEAEVTEHIVGLTYSLANCKFRKPLTWLSVHANGSNISKGCVDKDRIKKSAWLKSLVAIPGVSPGQAIAIEKKYPSMRSLLNVYMDDSKSVHEKEHLLEDLRLEGPLGDFKRRLGPACSKKVYTILMAQNGAAEVEVDRRGA

Gene
EME1
Protein
Crossover junction endonuclease EME1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
580 amino acids
Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the EME1/MMS4 family.
Mass
66.736 kDa
Sequence
MPTTPVIEILDDSSLLDDSLIEEIISDNNDNVIHPTEIDESIEISIPYVNDKTAESNSTSLGNSQKESSLIVTQTASQRKRILDEILSDDLSISTDDFSLDAIPKQTSGRTRDSQKNDSALYESSQEKASIASSPNRLIKKSSSERHKKSQSIDSKDICIKSPTRKINLGVTESMQTDVLFEDNNFNNIECTQETDLSFSTATADTPTVGFKEITFKHKESTNEGLNSHNFSDSIFERQRLKQYITNIRDITETESQELYNKLIHTEKGLFNAVNQTPRDNFKAREDIIVDFSPSLLSFLDKQTEILKSILAPATIQKSIHDELPRIRFFRKCHSFYDLQHDFFFPSNYKIVEENTTILYFDSKEFFVKYKEDKRSLFEKLKEIERDNYEIILVLYDLAKFKRELEKIEETKYRSRVQSQIYDSQQSIQQNKVTTPQSDYGLKKFDVEQRLRYINREWGLKIHIVNSHNDFVHSLPNLCSIIGKQRMDPAIRYMRYAHLNVKSASDRKDTLKKTINEIGKVPDIKASAISDIYSSFQSLLHDFEAGSLKASSDGNYLMSEALEKRLHKIFTSTDPNEAVD

Gene
EME1
Protein
Crossover junction endonuclease EME1
Organism
Pongo abelii
Length
575 amino acids
Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).
Similarity
Belongs to the EME1/MMS4 family.
Mass
63.795 kDa
Sequence
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPGLLSPPVPDIAETVTQTQPVRLLSSGSEDEEEFIPLAQRLKCKFLTHKQLSPEDSSSPIKSVLDHQNNEGASCDWKKQPFPKIPEVPLHDTLERSAADNKDLILDPCRQLPACLSTCPGQSSSLAVTKTNSDILPPQKKTKRSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVARMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQSMECRCVIEAQAVPCSVTWRRRAGPSEVLWQDGEDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITARTAGKALSLVIVDQEKCFSAQNPPRRGKQGANKQTKEKQQRQPEASIGSMVSRVDAEEALVDLQLHTEAQAQIVQSWKELADFTCAFTKAVAEVPFKKLRDETTFSFCVESDWAGGVKVDRAGRGLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYRQCFSEQERQNLLADIQVRRGEGVTSTSRRVGPELSRRIYLQMTTLQPHLSLDSAD

Gene
EME1
Protein
Crossover junction endonuclease EME1
Organism
Homo sapiens
Length
570 amino acids
Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Similarity
Belongs to the EME1/MMS4 family.
Mass
63.252 kDa
Sequence
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAPELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALSLVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTEAQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTSTSRRIGPELSRRIYLQMTTLQPHLSLDSAD

Gene
Eme1
Protein
Crossover junction endonuclease EME1
Organism
Mus musculus
Length
570 amino acids
Function
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Similarity
Belongs to the EME1/MMS4 family.
Mass
63.481 kDa
Sequence
MALRRLSLSRLSTESDSEDLPTFAFLKKEPSSTNRKPPQRAKNIVVVTSDSEASCPPSPGLKGPPCVPSAAGAPPQAGPVRVLSSSSEDEDVFVPLAERITCKLLTSKQLCPELSSSSLKTGLDGQNNASAPCDWKRQPWPKIPDVPLHGALEKSAANDEDSLLDDQCRQLPTYQATCRELAVSKTNSDRPLPKKRTKHIQTVQSGGSQGCWRPGQASRKENTPRQHERKKKAEMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRSITWRRRRTELVEDGDDWMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKGKETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQAKAKHQQRQESSTGLMVSRADMEKALVDLQLYTEAQAWMVQSWKELADFTCAFTKAVAEAPFKKLRDQVTFSFFLEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQNLLADIQVRRGEGVTATSRRVGPELSRRIYLQMTTAQPDLILDSVD