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ELP6

Gene
elp6
Protein
Elongator complex protein 6
Organism
Dictyostelium discoideum
Length
338 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. May be in involved in cell migration (By similarity).
Similarity
Belongs to the ELP6 family.
Mass
38.417 kDa
Sequence
MDLFSHLNWYSGDFMNEDGEPIKSIPSGKLILVSDTLESEGSFLIHYFLQSIFKATTSTNSSTNNNNSNNSGGVGGGACLLGLNQSLYNYFNVGRKLGYNLTTEYNKGNFTFINGLSTPYKWIIEQRLQQLEDQGIDEEPQLDSISQGFNPFPTIHLIDNKNITSSSSSSSYSNSNNKNKNNNELKDILYKIYNEFINDHKKRVMNNNNNSKTLFIIDGLNLLESHYSTNPSGSNMDILNFLQYCHNYIKENSTTCSMIILYHSDCDEDSKFFNLLQYESDLTINITGLKSGYSKDIDGQLNFIQKDEKNNTFTRVNPIHYQALDNSIRFFSMGSRIQ

Gene
ELP6
Protein
Elongator complex protein 6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
273 amino acids
Function
Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. ELP6 is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.
Similarity
Belongs to the ELP6 family.
Mass
30.574 kDa
Sequence
MGSVQRQDLVLFSDQSVLPAHFFQDSNSHNLFFITHQSCTQPLWMINALVETHVLGSPSSLNESSSSMLPSSTRSHAVLASFIHEQNYFTNSLNKLKIPSNNYNVLDFLSDFIVNNIHNKPRDKILSDVLAKFSAAIQNNPTDTIVIIEQPELLLSLVSGLTCSELNNKFITPLLRQCKVLIIVSNSDIFNIDEYDASVHSSNLQNFYKSSFIKSMINLNLNPLKTGFAKDVTGSLHVCRGGAPIATSNTSLHVVENEYLYLNEKESTKLFYR

Gene
ELP6
Protein
Elongator complex protein 6
Organism
Homo sapiens
Length
266 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.
Similarity
Belongs to the ELP6 family.
Mass
29.793 kDa
Sequence
MFVELNNLLNTTPDRAEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALIQSFSHYSIVGQKLGVSLTMARERGQLVFLEGLKSAVDVVFQAQKEPHPLQFLREANAGNLKPLFEFVREALKPVDSGEARWTYPVLLVDDLSVLLSLGMGAVAVLDFIHYCRATVCWELKGNMVVLVHDSGDAEDEENDILLNGLSHQSHLILRAEGLATGFCRDVHGQLRILWRRPSQPAVHRDQSFTYQYKIQDKSVSFFAKGMSPAVL

Gene
Elp6
Protein
Elongator complex protein 6
Organism
Mus musculus
Length
266 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.
Similarity
Belongs to the ELP6 family.
Mass
29.327 kDa
Sequence
MFPELNNLLSTTPDKTEQGTLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNIVGQKLGVSLTAARDRGQLVFLEGLKSSVEVLFHSQDEPHPLQFLREAGTGNLQSLYTFIQDTLKPADSEESPWKYPVLLVDNLSVLLSLGVGAVAVLDFMQYCRATVCCELKGNVVALVHDTEGATDEGNDTLLNGLSHQSHLILRAEGLATGFCKDVHGQLSILWRRPSRSTAQRAQSLTYQYKIQDKNVSFFAKGMSPAVL

Gene
Elp6
Protein
Elongator complex protein 6
Organism
Rattus norvegicus
Length
266 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity).
Similarity
Belongs to the ELP6 family.
Mass
29.459 kDa
Sequence
MFPELNNLLSITPDRTEQGKLTLLCDAKTDGSFLVHHFLSFYLKANCKVCFVALVQSFSHYNIVGQKLGVSLTAARERGQLVFLEGLKSSVEVLFHSQEEPHPLQFLREAGAGNLQSLYTFIQDTLKPADSGESPWKCPVLLVDNLSVLLSLGVGAVAVLDFMQYCRATVCCELKGNVVALVHDTEGAEDEENNILLNGLSHQSHLILRTQGLATGFCKDVHGQLSILWRRSSQPTAQRARSLTYQYKIQDKNVSFFAKGMSRAVL

Gene
elp6
Protein
Elongator complex protein 6
Organism
Xenopus tropicalis
Length
266 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. May be in involved in cell migration (By similarity).
Similarity
Belongs to the ELP6 family.
Mass
29.235 kDa
Sequence
MFPELNSLLGAGTDTVERGKFTLLCDSKTDGSFLVHHFLSYYLRAGCRVCFVALVQSFSHYSIVAQKLGVNLSSAKDEGQLVFLEGLRSYTDLLFGDNPEAEVTNPLCFLRAGSDLKPLYSFVSAALAPSAGQSWKCPVLILDDVSVLLSLGVPPLQLLDFMHYCRATVCTQYQGNVVCLVHGAEESGDEEKELLRRSLSHQSQVILWAEGLSSGFCKEVHGQLKIFRGAVSSGKKRGQTQPEIYQYKIQDKHVTFFARGLSAAVL

Gene
elp6
Protein
Elongator complex protein 6
Organism
Xenopus laevis
Length
265 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. May be in involved in cell migration (By similarity).
Similarity
Belongs to the ELP6 family.
Mass
29.029 kDa
Sequence
MFPELNSLLGVTTDTLTLGKFTLLCDSNTDGSFLVHHFLSYYLRAGCRVCFVALVQSFSHYNIVAQKLGVNLSSAKDEGQLVFLEGLKSYTDLLFGDKSEAEETNPLCFLRAGSDLRPLYSFVSAALAPSAGQPWKCPVLILDDLSVLLSLGVTSLQVLDFMHYCRATVCTQYKGNVLCLVHGAEESGDEENELVLRSLSHQSHLILQAEGLSTGFCKDVHGQLKIIRGAVSSGKRGKNQPEIYQYKIQDKHVAFFARGLSAAVL

Gene
elp6
Protein
Elongator complex protein 6
Organism
Danio rerio
Length
264 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. May be in involved in cell migration (By similarity).
Similarity
Belongs to the ELP6 family.
Mass
29.24 kDa
Sequence
MFPELNSLLNASPDTFKPGDFILLSDRQADASFLIHHYLSFYLRAGCKVCFLGLVQSFSHYSAVGQRLGVSLTQAREKGQLVFLEGLKDSIGAILKEDTSEGTQALSYLRSPRAGLEGLFRFVESSLCQSGDDGPPVLIIDDLSVLLSLGVSAGAILDFTLYCRATVCSELQGNMVILVRCEEEDADDDEEGLNLLQRGLVHQCHLALHVEGLPTGYCRDIHGQMEVWWRQGENDAYNQRKIFQFKVHDKGASFFTRGTSRAVL

Gene
ELP6
Protein
Elongator complex protein 6
Organism
Arabidopsis thaliana
Length
262 amino acids
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity). Promotes organs development by modulating cell division rate. Involved in oxidative stress signaling. Prevents anthocyanins accumulation.
Similarity
Belongs to the ELP6 family.
Mass
29.125 kDa
Sequence
MDRSLNLLDLALGFDEQLAIPSPLNGKVILIEDCVETSGSFVLHQLMKRVLSSNSSDALIFLAFARPFSHYDRILRKLGCNLATHKSNNRLVFFDMLMVKCSDGDQMEDNVSAVAKLFREIQETVRKLQSVTSGNITVMVDDMSLLEIATTGSNSDHVLDFLHYCHTLSSESNCSLVILNHEDIYASMERPAFLLQMVCLADVVIKAEPLASGLANDVHGQLTVLNKGISNSGRGSSRNKLQNFQFRIKENGIDYFYPGCRS

Gene
elp6
Protein
Elongator complex protein 6 homolog
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
249 amino acids
Similarity
Belongs to the ELP6 family.
Mass
28.173 kDa
Sequence
MSSLHEHLRPIPEPFSLTLLLGTRETPVTFLFHYYLYHALKAKESTCFLTFSKTLDEHAISMRKWGMDIKTKKNFFFIDGFSMLFAPISKPSKVQAPETKNHIKSVFAPVIQCVEENDFEFENSTIIIEDIDILQSTHALDSTKIQQAILELRKCFSRVIVNVTLGAPLPQQKSLGSSIGHMATRCISCRPLTSGSARRITGFLRLSRMPNHFRSGICETPEDDDKELLYEVTEAGAKVYSKGQVTLQL