Protein
Elongator complex protein 1
Organism
Oryctolagus cuniculus
Function
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).
Similarity
Belongs to the ELP1/IKA1 family.
Sequence
MRNLKLLQTLEFKDIQAPGKPQCFSLRTEPGTVLIGSEHGLIEVDPVTREVKNEIPLVAEGFLPEDKSGCIVGIQDLLDQESVCIATASGDVILCNLSTHQLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPIMEQQIHQDDFGESKFITVGWGKKETQFHGSEGRQAAFQIQTHESALPWDDHRPRVTWRGDGQFFAVSVVCPETGARKVRVWNREFALQSTSEPVPGLGPALAWKPSGSLIASTQNKPNQQDVVFFEKNGLLHGQFTLPFLKDEVKVNDLLWNADSSVLAVWLEDLQREEDSVLKTYVQLWTVGNYHWYLNECLPFSTYGKSKIVSLMWDPVIPYRLHVLCQGWHYLCYDWRWTTDRSSGDNESDLANVAVIDGNRILVTVFQQTVVPPPMCTYRLLLPHPVNQVTFCALPKKSNDLAVLDASNQISVYKCGDSPSMDPTVKLGAVGGNGFKVSLRTPHLEKRYKIQFESNEDQETNPLKLSLLSWIEEDIFLAICHSQCSPQQSVIHRLTVVPCEVDEEQGQLSVSSSISVDGIIISMCCNSKTKSVALQLADGQILKYIWESPSLAVEPWKNPGGFPIQFPYPCIQTELAMIGGEECVLGLTDRCRFFINDTEVASNITSFAVYDEFLLLTTHSHTCQCYCLKDASIKTLQAGLSSSHVSNGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKIMFKEAFECMRKLRINLNLIHDHNPEVFLQNVETFIRQIDCVNHINLFFTELKEEDVTKTMYPPPVPSSVQQSRDPGGTKLDLICDALRVAMENINPHKYCLPILTSHVKKTTPELEIVLQKVHELQGNAPSDPDAVSAEEALKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCGPEYFSECLNLIKDKNLYNEALKLYPPTSQEYKDISIAYGEHLMEEHQYEPAGLVFARCGAHEKALSAFLTCGSWQQTLCMAAQLNMTEEQLAGLGRTLAGKLAEQRKHSDAAIVLEQYTQDYEEAVLLLLEGAAWEEALRLVYKYNRLDIIETNIKPSILEAYKNYMAFLESQSATFSRHKERLLEVRELKERAQQVDLDDEMPHGQEADLFSETSSIVSGSEMSSKYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEDLALLEALNEVVQSLDKLKDEVYRILKVLFLFEFDEQGRELQKTFQDTLQLVERSLPEIWTLTYQQNSAMPVLGPSSTANSIMASYQQQKTSVPVLDAELFVPPKINRKTQWKLSLLE