About Products Protein Database Contact

EIF2D

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Homo sapiens
Length
584 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Similarity
Belongs to the eIF2D family.
Mass
64.706 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPGKEELNIVKLYAHKGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVMPPAGLPQVQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSGLKGRGFSVLHTYQDHLWRSGNKSSPPSIAPLALDSADLSEEKGSVQMDSTLQGDMRHMTLEGEEENGEVHQAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDELLQQCFLHALKCRVKKADLPLLTSTFLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSFLEGSEVRTIVINYAKKNDLVDADNKNLVRLDPILCDCILEKNEQHTVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKGRICPIDITLAQRASNKKVTVVRNLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQGNQVHHLGWLLLEEYQLPRKHIQGLEKALKPGKKK

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Pongo abelii
Length
584 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).
Similarity
Belongs to the eIF2D family.
Mass
64.676 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPGKEELNIVKLYAHKGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVMPPAGLPQVQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSGLKGRGFSVLHTYQDHLWRSGNKSSPPSIAPLALDSADLSEEKGSVQMDSTLQGDMRHMTLEGEEENGEVHQAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDELLQQCFLHALKCRVKKADLPLLASTFLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSFLEGSEVRTIVINYAKKNDLVDADNKNLVRLDPILCDCILEKNEQHTVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKGRICPIDITLAQRASNKKVTVVRNLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQGNQVHHLGWLLLEEYQLPRKHIQGLEKALKPGKKK

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Homo sapiens
Length
584 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Similarity
Belongs to the eIF2D family.
Mass
64.706 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPGKEELNIVKLYAHKGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVMPPAGLPQVQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSGLKGRGFSVLHTYQDHLWRSGNKSSPPSIAPLALDSADLSEEKGSVQMDSTLQGDMRHMTLEGEEENGEVHQAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDELLQQCFLHALKCRVKKADLPLLTSTFLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSFLEGSEVRTIVINYAKKNDLVDADNKNLVRLDPILCDCILEKNEQHTVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKGRICPIDITLAQRASNKKVTVVRNLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQGNQVHHLGWLLLEEYQLPRKHIQGLEKALKPGKKK

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Pongo abelii
Length
584 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).
Similarity
Belongs to the eIF2D family.
Mass
64.676 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPGKEELNIVKLYAHKGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVMPPAGLPQVQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSGLKGRGFSVLHTYQDHLWRSGNKSSPPSIAPLALDSADLSEEKGSVQMDSTLQGDMRHMTLEGEEENGEVHQAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDELLQQCFLHALKCRVKKADLPLLASTFLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSFLEGSEVRTIVINYAKKNDLVDADNKNLVRLDPILCDCILEKNEQHTVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKGRICPIDITLAQRASNKKVTVVRNLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQGNQVHHLGWLLLEEYQLPRKHIQGLEKALKPGKKK

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Bos taurus
Length
579 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).
Similarity
Belongs to the eIF2D family.
Mass
63.647 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVAAVFPTLGTDQVSELVPGKEELNIVKLYAHRGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVVPPAGLPQVQKGDLCAVALVGNRAPVAVGVAAMSTAEMLASGLKGRGFCVLHSYQDHLWRSGDKSSPPSIAPLALNPPDLSEGKGCVKADTALQGAMRQLTLEEEVQQRCEEKSPSEATEDPGPGGLHVDPMDSKTLQEQMDELLQTCFLHALKCSVRKADLPLLTSTLLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQHMQQEQIIQVQELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSVLEGSEVRTFVINYAKKNDLVDADNKNLVKLDPILCDCILEKDEQHTVTKLPWDSLLGRCLEKLQPAYQVTFPGQEPIVKKGRICPIDITLAQKASNKKVTVVRNLEAYGLDPRSVAATLQQRCQASTTVTSAPGLKDSVQVQIQGNQIHHLGRLLLEEYRLPRKHIQGLEKAPKPGKKK

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Bos taurus
Length
579 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).
Similarity
Belongs to the eIF2D family.
Mass
63.647 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVAAVFPTLGTDQVSELVPGKEELNIVKLYAHRGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVVPPAGLPQVQKGDLCAVALVGNRAPVAVGVAAMSTAEMLASGLKGRGFCVLHSYQDHLWRSGDKSSPPSIAPLALNPPDLSEGKGCVKADTALQGAMRQLTLEEEVQQRCEEKSPSEATEDPGPGGLHVDPMDSKTLQEQMDELLQTCFLHALKCSVRKADLPLLTSTLLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQHMQQEQIIQVQELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSVLEGSEVRTFVINYAKKNDLVDADNKNLVKLDPILCDCILEKDEQHTVTKLPWDSLLGRCLEKLQPAYQVTFPGQEPIVKKGRICPIDITLAQKASNKKVTVVRNLEAYGLDPRSVAATLQQRCQASTTVTSAPGLKDSVQVQIQGNQIHHLGRLLLEEYRLPRKHIQGLEKAPKPGKKK

Gene
Eif2d
Protein
Eukaryotic translation initiation factor 2D
Organism
Mus musculus
Length
570 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).
Similarity
Belongs to the eIF2D family.
Mass
62.83 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTAAFPALGTDQISELIPGKEELNVVKLYVHKGDSVTVYTSGGNPILFELEKNLYPTVYTLWAYPDILPTFITWPLVLEKLVGGADLMLPGVVVPPTGLPQVQQGDLCAIALVGNRAPVAIGVAAMSTAQMLASGLKGKGVSVLHTYQDHLWRSGDKSSPPAIAPLDPTDSCEEKVHLGLQGNLKSLTLDGEEENGQVPLREASEDTSSRAPSQDSLDGKPLQEQMDDLLLRCFLHALKSRVKKADLPLLTSTLLGSHMFSCCPEGQQLDIKKSSYKKLSKFLQHMQQEQIVQVKELSKGVESIVAVDWRHPRITSFVIPEPSLTSQTVQEVSREQPYLPPDIKSLYCVPANMTQLFLESGHKKGSTLEGSEVRKIITDYAKRNRLVDADNRNLVKLDPILCDCILEKNEQHLVTKLPWDCLLTRCLKNMQPAYQVTFPGQEPILKKGKLCPIDITLALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLGQLLLEEYRLPGKYIQGLEKAPKPGKK

Gene
Eif2d
Protein
Eukaryotic translation initiation factor 2D
Organism
Mus musculus
Length
570 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).
Similarity
Belongs to the eIF2D family.
Mass
62.83 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTAAFPALGTDQISELIPGKEELNVVKLYVHKGDSVTVYTSGGNPILFELEKNLYPTVYTLWAYPDILPTFITWPLVLEKLVGGADLMLPGVVVPPTGLPQVQQGDLCAIALVGNRAPVAIGVAAMSTAQMLASGLKGKGVSVLHTYQDHLWRSGDKSSPPAIAPLDPTDSCEEKVHLGLQGNLKSLTLDGEEENGQVPLREASEDTSSRAPSQDSLDGKPLQEQMDDLLLRCFLHALKSRVKKADLPLLTSTLLGSHMFSCCPEGQQLDIKKSSYKKLSKFLQHMQQEQIVQVKELSKGVESIVAVDWRHPRITSFVIPEPSLTSQTVQEVSREQPYLPPDIKSLYCVPANMTQLFLESGHKKGSTLEGSEVRKIITDYAKRNRLVDADNRNLVKLDPILCDCILEKNEQHLVTKLPWDCLLTRCLKNMQPAYQVTFPGQEPILKKGKLCPIDITLALKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLGQLLLEEYRLPGKYIQGLEKAPKPGKK

Gene
Eif2d
Protein
Eukaryotic translation initiation factor 2D
Organism
Rattus norvegicus
Length
570 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).
Similarity
Belongs to the eIF2D family.
Mass
62.669 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTVAFPTLGTDQVSELIPGKEELNVVKLYAHKGDAVTVYTSGGNPILFELEKNLYPTVYTLWSHPDLLPAFITWPLVLEKLVGGADLMLPGVVVPPTGLPQVQQGDLCAIALVGNRAPVAVGVAAMSTAQMLASGLKGKGISVLHTYQDHLWRSGDKSSPPAIAPLDPTDSCEEKADLGLHGNLRSLSLEGEEENGQVPNPEASDDPNSRALSQDSVDGKPLQEQMDELLEQCFLHALKSRVKKADLPLLTSTLLGSHMFSCCPEGQQLDIKKSSYKKLSKFLQHMQQEQIVQVKELSKGVESIVAVDWRHPRITSFIVPEPSLASQTVQEGSREKPYLPPDIKSLYCVPANMTQLFLESGHKKGSTLEGSEVRRIITDYAKRNNLVDADNRNLVKLDPILCDCILEKNEQHLVMKLPWDSLLTRCLKNLQPAYQVTFPGQEPIIKKGKLCPIDITLVLKTYNKKVTVVRNLETYGLDPCSVAAILQQRCQASTIVSPAPGAKDSLQVQVQGNQIHHLGQLLLEEYRLPGKYIQGLEKAPKPGKK

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Oryctolagus cuniculus
Length
566 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Similarity
Belongs to the eIF2D family.
Mass
62.209 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVAAAFPTLGTDQVSELVPGKEELNTVKLYAHRGDAVTVYVSGGNPILFELEKNLYPTVYMLWSHPDLLPTFTTWPLVLEKLVGGADLMLPGLVVPPAGLPQVQKGDLCAIALVGNRAPVAIGVAAMSTEEMLTSGLKGRGFSVLHTYQDHLWRSGDKSSPPSIAPLVVDPADLNDDKESVQVNPVLQGEEEGNGETALSEATSAGGQDQDPTDSRTLQEQMDELLQQCFLHALKCRIQKADLPLLTSTLLGSHMFSCCPEGHQLDIKKSSYKKLSKFLQHMQQEQIVQVKELSRGVESVVAVDWRHPRITSFVIPEPSLTSQSVQEGSREQPYRPPDIKPLYCVPASMTLLFQESGHKKGSVLEGSEVRAIIINYAKKNDLVDADNKNLVKLDPVLCDCLLEKHEQHSIMKLPWDSLVTRCLEKLQPAYQVTFPGQEPVVKKGKICPIDITLAQRASNKKVTVVRNLEAYGLDPGSVAATLQQRCQASTTVTPAPGAKDSLQVQIQGNQVHHLGRLLLEEYHLPRKYIQGLEHAPKASKKK

Gene
EIF2D
Protein
Eukaryotic translation initiation factor 2D
Organism
Oryctolagus cuniculus
Length
566 amino acids
Function
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Similarity
Belongs to the eIF2D family.
Mass
62.209 kDa
Sequence
MFAKAFRVKSNTAIKGSDRRKLRADVAAAFPTLGTDQVSELVPGKEELNTVKLYAHRGDAVTVYVSGGNPILFELEKNLYPTVYMLWSHPDLLPTFTTWPLVLEKLVGGADLMLPGLVVPPAGLPQVQKGDLCAIALVGNRAPVAIGVAAMSTEEMLTSGLKGRGFSVLHTYQDHLWRSGDKSSPPSIAPLVVDPADLNDDKESVQVNPVLQGEEEGNGETALSEATSAGGQDQDPTDSRTLQEQMDELLQQCFLHALKCRIQKADLPLLTSTLLGSHMFSCCPEGHQLDIKKSSYKKLSKFLQHMQQEQIVQVKELSRGVESVVAVDWRHPRITSFVIPEPSLTSQSVQEGSREQPYRPPDIKPLYCVPASMTLLFQESGHKKGSVLEGSEVRAIIINYAKKNDLVDADNKNLVKLDPVLCDCLLEKHEQHSIMKLPWDSLVTRCLEKLQPAYQVTFPGQEPVVKKGKICPIDITLAQRASNKKVTVVRNLEAYGLDPGSVAATLQQRCQASTTVTPAPGAKDSLQVQIQGNQVHHLGRLLLEEYHLPRKYIQGLEHAPKASKKK