Protein
Protein-lysine N-methyltransferase EFM5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-79' (PubMed:25446118). Required for replication of Brome mosaic virus (BMV) (PubMed:14671320).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
Sequence
MSDSDSDSDYELTLSANALAALEEFKREEQQHQEAFQKLYDETDEDFQKKKKEEGMKLFKEDWQLSQFWYSDDTAAILADAILEGADENTVIAIVSAPSVYAAIQKKPTNEIPTEHIYLFEFDKRFELLAGRDHFFFYDYNKPLDFSDEIKGKVDRLLIDPPFLNEDCQTKSSITAKCLLAPNDNSKTKKGVFKHRLISCTGERMSEVISKVYSDTRITTFLPEHSNGLSNEFRCYANFECSSWKFAS