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ECO1

Gene
ECO1
Protein
N-acetyltransferase ECO1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
288 amino acids
Function
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity).
Similarity
Belongs to the acetyltransferase family. ECO subfamily.
Mass
32.257 kDa
Sequence
MKRDITQLLSPELSQSSSRNDKKRKPTNSNKKVQTVLNFPSSSPNASQSTTCPTCGMTYYSHVSKDNDVHNKYHFNFINGIPWPTSFCNNVLERFIVVDHTTGKAKGTSKSKKSQAASKETLVMTIDRRASKQVKRVEEILKVVNGELNAASDGKAWQKDHKGPIQGRAFIVVIDGRAIGICTTEPIQDVDQQCRWIIHRTQALVPNQVNRSIKLGISRIWIAPKWRRYGLARRLLDIVLVHSVYGIVLDKKEIGFSQPSFSGGLLAKSFNGVTHKSGEILIPVYLEE

Gene
ECO1
Protein
N-acetyltransferase ECO1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
281 amino acids
Function
Required for establishment of sister chromatid cohesion during S phase but not for its further maintenance during G2 or M phases or for loading the cohesin complex onto DNA. Interacts with the three known alternate replication factor C (RFC) complexes, suggesting that these complexes have essential but redundant activity in cohesion establishment. Acts by acetylating the cohesin complex component SMC3. In vitro, possesses acetyltransferase activity where it can acetylate itself and components of the cohesin complex (MCD1, IRR1 and PDS5), but is unable to acetylate histones.
Similarity
Belongs to the acetyltransferase family. ECO subfamily.
Mass
31.845 kDa
Sequence
MKARKSQRKAGSKPNLIQSKLQVNNGSKSNKIVKCDKCEMSYSSTSIEDRAIHEKYHTLQLHGRKWSPNWGSIVYTERNHSRTVHLSRSTGTITPLNSSPLKKSSPSITHQEEKIVYVRPDKSNGEVRAMTEIMTLVNNELNAPHDENVIWNSTTEEKGKAFVYIRNDRAVGIIIIENLYGGNGKTSSRGRWMVYDSRRLVQNVYPDFKIGISRIWVCRTARKLGIATKLIDVARENIVYGEVIPRYQVAWSQPTDSGGKLASKYNGIMHKSGKLLLPVYI

Gene
ECO1
Protein
N-acetyltransferase ECO1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
271 amino acids
Function
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity).
Similarity
Belongs to the acetyltransferase family. ECO subfamily.
Mass
30.936 kDa
Sequence
MSKYRSPKTKKSIQATLQFKSTPTLVKCPKCSITYSTNSPSDLVQHKRYHDLHLNGKRWSQSWGDIINRVEALKTEKQLKYSMVSEKDKKVMSFQLPSQTLYEEDEYIVMISPKKANEVKAALDLMSIVNEELNAPHDENAFWSEVDKSGKSQGKAFIYVKKNRAVGVITIEYIENTNRGKWMVLDTKAIVPNVVPDVKLGISRIWVCRNQRQHGIATRLLEVARKKSIYGCIVNKWELAWSQPSQSGSILAKSYNAAKHRSGKLLIPCYI

Gene
ECO1
Protein
N-acetyltransferase ECO1
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
271 amino acids
Function
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity).
Similarity
Belongs to the acetyltransferase family. ECO subfamily.
Mass
29.891 kDa
Sequence
MKTYRAKRKYLSESEDDVFSSSPTQSPETSPLQPPNESRLNIKAAQAVSPCQKRAKVVKKPAKTKAPVQMTLSLGQTTSTTCKTCGMTYQVAYGPDISAHKSFHSTALNGPKWKPSVSAVVVDKSKTYTVYKSRLLSHPCVSQFLKLVNSELNAPEPILSSQAAVYVYVVDQRAVGCVLVDRITKCRHVDIQTGTLGLKEYPAVMGVSRMYVSQLFRRTGIVTKLLDLAKSDFIYGMELEKNQVAFTQPSEGGLKVAENWAGTVRVYREGE

Gene
ECO1
Protein
N-acetyltransferase ECO1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
266 amino acids
Function
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity).
Similarity
Belongs to the acetyltransferase family. ECO subfamily.
Mass
29.944 kDa
Sequence
MAGVKKNRSPRKPTKLLQSRLKFAHSSATLKKCTECQMSYIIDSPADCAEHKKYHDLHLYGKKWLASWGTAIQDTCSSQYITPPSTSGGNASGNGAKADREDYIVYITPGKTAEVKAMMEIMYIVNNELTAPHDENDFWSEEGTSSMGRAFVYIKDGRAVGAITVEYLKEDDSRGRWMRVSTRELVPEVVPRVRLGISRIWVCRKQRGQGIATRLLECVRKYAILGNEVARWEMAWSQPSESGGKLATRYNSVRHKSGELLIPCYI

Gene
ECO1
Protein
N-acetyltransferase ECO1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
261 amino acids
Function
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity).
Similarity
Belongs to the acetyltransferase family. ECO subfamily.
Mass
29.527 kDa
Sequence
MAVNHVRSKSSNGKRLVQSKLNINNETILKCPKCEMKYSPNSIDDVATHKKYHDLHINGRNWSQTWGIPIHDTTSSTIIATPSSSPFKTGKSVNNKNNERIVMIQENKPAEVKAMLEIMDIVNQELNAPQDENNFWRKPNAEHQGKAIVYIKDKKVVGAITVEVLKQHKCRWMIYETRTLVEHVRPQFTLGISRIWVCRAQRGKGIAEKLLDAARISAIPGQNVDKMKLAWSQPSDSGGKLAKKYNGVKHKSGHILIPCYL