ECE1

Gene

ECE1

Protein

Endothelin-converting enzyme 1

Organism

Homo sapiens

Length

770 amino acids

Function

Converts big endothelin-1 to endothelin-1.

Similarity

Belongs to the peptidase M13 family.

Mass

87.164 kDa

Sequence

MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW

Protein

Endothelin-converting enzyme 1: ECE1

Gene

Ece1

Protein

Endothelin-converting enzyme 1

Organism

Mus musculus

Length

769 amino acids

Function

Converts big endothelin-1 to endothelin-1.

Similarity

Belongs to the peptidase M13 family.

Mass

87.073 kDa

Sequence

MRTVWSPLAAALAALGMSTYKRATLDEEDLVDSLSEGDVYPNGLQVNFRSSRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYQTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW

Protein

Endothelin-converting enzyme 1: Ece1

Gene

Ece1

Protein

Endothelin-converting enzyme 1

Organism

Rattus norvegicus

Length

762 amino acids

Function

Converts big endothelin-1 to endothelin-1.

Similarity

Belongs to the peptidase M13 family.

Mass

86.126 kDa

Sequence

MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW

Protein

Endothelin-converting enzyme 1: Ece1

Gene

ECE1

Protein

Endothelin-converting enzyme 1

Organism

Bos taurus

Length

754 amino acids

Function

Converts big endothelin-1 to endothelin-1.

Similarity

Belongs to the peptidase M13 family.

Mass

85.517 kDa

Sequence

MMSTYKRATLDEEDLVDSLSESDVYPNHLQVNFRGPRNGQRCWAARTPVEKRLVVLVALLAAALVACLAVLGIQYQTRTPSVCLSEACISVTSSILSSMDPTVDPCQDFFTYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELKAKPLMELIEKLGGWNITGPWDKDNFQDTLQVVTSHYHTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGAEDTIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVIYDKEYLSKVSTLINSTDKCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENTLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTACMVEQYGNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTNNQLFFLSFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSISNSKEFSEHFHCPPGSPMNPHHKCEVW

Protein

Endothelin-converting enzyme 1: ECE1

Gene

ECE1

Protein

Endothelin-converting enzyme 1

Organism

Cavia porcellus

Length

754 amino acids

Function

Converts big endothelin-1 to endothelin-1.

Similarity

Belongs to the peptidase M13 family.

Mass

85.772 kDa

Sequence

MMSTYKRATLDEEDLVDSLSEGEVYPNGLQVNFRNFRSSQRCWATRTQVEKRLIVLVALLAAGLVACLTALGIQYRTRTPPVCLSEACVSVTSSILNSMNPTVDPCQDFFSYACGGWIKANPVPDGHSRWGAFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNRNVIHVDQSGLGLPSRDYYLNKTENEKVLNGYLNYMVQLGKLLGGGDENAIRAQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQVSTLINTTDKCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFGLGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTAEQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILPAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEETLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFQCPPGSPMNPRHKCEVW

Protein

Endothelin-converting enzyme 1: ECE1

Gene

ECE1

Protein

Extent of cell elongation protein 1

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

271 amino acids

Function

Candidalysin ECE1-III: Acts as a cytolytic pepdide toxin that directly damages host epithelial membranes, triggers a danger response signaling pathway and activates epithelial immunity (PubMed:27027296). Probably acts similarly to cationic antimicrobial peptide toxins, inducing lesions after binding to target cell membranes and causing an inward current associated with calcium influx (PubMed:27027296).

Mass

28.878 kDa

Sequence

MKFSKIACATVFALSSQAAIIHHAPEFNMKRDVAPAAPAAPADQAPTVPAPQEFNTAITKRSIIGIIMGILGNIPQVIQIIMSIVKAFKGNKREDIDSVVAGIIADMPFVVRAVDTAMTSVASTKRDGANDDVANAVVRLPEIVARVATGVQQSIENAKRDGVPDVGLNLVANAPRLISNVFDGVSETVQQAKRDGLEDFLDELLQRLPQLITRSAESALKDSQPVKRDAGSVALSNLIKKSIETVGIENAAQIVSERDISSLIEEYFGKA

Protein

Extent of cell elongation protein 1: ECE1