Protein
Chromatin modification-related protein EAF3
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
Similarity
Belongs to the MRG family.
Sequence
MAIVLDGKCLCYHGPLLYEAKVLRVYDEKNQTITSKDYKDVSIDDEKVEFDRPPEHMRQGQCYFVHYQGWKSSWDEWVGLDRIRPYNDENLELKKSLVEKARELKNNGGKKKSGSRPVGRPSKVEKGKKAASRTSNSGSGTNTSASSTSASNPASSSSSGTTAAASSSDKSDRKKATPVLNKRSHPKIHIKVPISLRSVLVDDWENVTKDRKLVQLPSERPIEHILSQFYADTSNSTSSVVEQAQLSEFLQGIKLYFNLSLGKLLLYRLERIQYAELLKAHSEKQYTEIYGIIHLLRLVTLLPEMMESSNVDDQTAKILVKQCDILLEWIAINIARKNFPVDPYINTSSQYEGVALSM