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Drs

Gene
Drs
Protein
Drosomycin
Organism
Drosophila melanogaster
Length
70 amino acids
Function
Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi (PubMed:8808632, PubMed:12872120). It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology (PubMed:7806546). Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway (PubMed:8808632). Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system (PubMed:18854145).
Mass
7.752 kDa
Sequence
MMQIKYLFALFAVLMLVVLGANEADADCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC