Def8

Gene

Def8

Protein

Differentially expressed in FDCP 8 homolog

Organism

Rattus norvegicus

Length

451 amino acids

Function

Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.

Similarity

Belongs to the DEF8 family.

Mass

52.697 kDa

Sequence

MEYDEKLVRFRQAHLNPFNKHLGPRHHEQEPNEKAQEVTSEDTLPELPAGEPEFCYSERMMDLGLSEDHFSRPVGLFLASDVQQLRQAIEECKQVILELPEQSEKQKDAVVRLIHLRLKLQELKDPNEEEPNIRVLLEHRFYKEKSKSVKQTCDKCNTIIWGLIQTWYTCTGCYYRCHSKCLNLISRPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRGVPSEARQCDYTGQYYCSHCHWNDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPVLRLREINPLLFNYVEELVEIRKLRQDILLMKPYFITCKEAMEARLLLQLQDRQHFVENDEMYSIQDLLEVHMGRLSCSLTEIHTIFAKHIKLDCERCQAKGFVCELCKEGDVLFPFDSHTSVCNDCSAVFHRDCYYDNSTTCPKCARLTLRKQSLFQEPGLDVDA

Protein

Differentially expressed in FDCP 8 homolog: Def8

Gene

Def8

Protein

Differentially expressed in FDCP 8

Organism

Mus musculus

Length

448 amino acids

Function

Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Involved in bone resorption (PubMed:27777970).

Similarity

Belongs to the DEF8 family.

Mass

52.311 kDa

Sequence

MEYDEKLVRFRQAHLNPFNKQLGPRHHEQEPSEKVTSEDTLPELPAGEPEFHYSERMMDLGLSEDHFSRPVGLFLASDVQQLRQAIEECKQVILELPEQSEKQKDAVVRLIHLRLKLQELKDPNEEEPNIRVLLEHRFYKEKSKSVKQTCDKCNTIIWGLIQTWYTCTGCCYRCHSKCLNLISKPCVSSKVSHQAEYELNICPETGLDSQDYRCAECRAPISLRGVPSEARQCDYTGQYYCSHCHWNDLAVIPARVVHNWDFEPRKVSRCSMRYLALMVSRPVLRLREINPLLFNYVEELVEIRKLRQDILLMKPYFITCKEAMEARLLLQLQDRQHFVENDEMYSIQDLLEVHMGRLSCSLTEIHTLFAKHIKLDCERCQAKGFVCELCKEGDVLFPFDSHTSVCNDCSAVFHRDCYYDNSTTCPKCARLTLRKQSLFQEPGLDMDA

Protein

Differentially expressed in FDCP 8: Def8

Gene

def8

Protein

Differentially expressed in FDCP 8 homolog

Organism

Xenopus tropicalis

Length

443 amino acids

Function

Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.

Similarity

Belongs to the DEF8 family.

Mass

51.439 kDa

Sequence

MEYDDKLVRFRQGHLNPFDKQGEAERQPAACETEPSKDFPTSSPLSVPEFHCPDRVMDLGVSEDHFSRPVGLFLASDIQQLRQAIEECKQEILELPEHSDRQKDAVVRLIHLRLKLQELNDPLEDEPNLRILLEHRFYKEKSKSVKHLCDKCSTFIWGLIQTWYTCTGCSYRCHSKCLNLITKPCVRSKVSHQAEYELSICPEAGLDSQDYRCAECRTPISLRSVPSEARQCDYTGQYYCISCHWNDIAVIPARAIHNWDFEPHKVSRCSMRYLALMLGRPVLKLREINPLLFNYVEELVEIRKLRQDILLMKPYFITCKEAMEARLLLQLQDRQHFVENDDMYSLQDLLDISSGRLGCSLTEIHTTFAKHIKLDCERCQAKGFVCELCKEGDILFPFDSHTSVCQDCAAVFHRDCYYDNSTSCPRCTRLNLRKQVQNPGEEP

Protein

Differentially expressed in FDCP 8 homolog: def8