Protein
Dual specificity protein phosphatase 18
Organism
Rattus norvegicus
Function
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Sequence
MTSPWSACPVQFPQPSISGLSQITKSLFISNGAAANDKLLLSSNQITTVINVSVEVANTFYEDIQYVQVPVVDAPIARLSDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHVMSLLDAHAWTKSRRPIIRPNSGFWEQLIHYEFQLFGKNTMQMVNSPMGLIPDIYEKETRMMIPLSTPDGAFHKGKEKALL