DSL1

Protein transport protein DSL1

754 amino acids

Required for protein transport between the Golgi and the endoplasmic reticulum. May tether coatomer-coated retrograde transport vesicles to the ER membrane through interaction with coatomer as well as the SNARE complex. May contribute to the stabilization of the SNARE complex.

88.072 kDa

MESLFPNKGEIIRELLKDPLILKNDSKRSNGSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMRNNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITENSIQFTPTVEWGKDKVHIEYDTFMDFVAQQYFPKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSSSHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPLKNLVSVINNKLTRLVAKSEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIRSIFEDPKKSWQNLEVVELTTSNTNTMSEKIGKNDSDVQNEKELHNAVSKDDDWNWEVEDDDADAWGDEIDVNIDDEEEKTNQEKEKEPEEEENAWDEAWAIDENIDDASLENGKEHLKAHDVGSLDKDHIEVTQLPKLFLAISQNFKSSFADSHVDEQYFAYKYNLLQTSYMAMCTANFSHNWCQLYVDMRYLIERDEKLYRIKELTRNLLETKLNMKYRIVCQLIRHQLTEFRENERNPSWDATIEKLLPYILKEIVRPLQKIRGEEGSRYLLSFLNFLYNDCVTKEILKWQIISEVNSENLGELVSLLVNNTDIQLLAKEPSYKKMREKFATMGKFLPLHLKEIMEMFYNGDFYLFATDELIQWIELLFADTPLRRNAIDDIYEIRGTALDD

DSL1

Dorsalin-1

427 amino acids

Appears to regulate cell differentiation within the neural tube. May regulate the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate. Controls the cell differentiation in the neural tube in several ways: (1) promotes the differentiation of cell types that derive from the dorsal neural tube. (2) ensures that the dorsal neural tube is refractory to ventralizing species from the notochord. (3) can diffuse and influence the fate of cells in more ventral regions of the neural tube.

Belongs to the TGF-beta family.

48.626 kDa

MHYFGVLAALSVFNIIACLTRGKPLENWKKLPVMEESDAFFHDPGEVEHDTHFDFKSFLENMKTDLLRSLNLSRVPSQVKTKEEPPQFMIDLYNRYTADKSSIPASNIVRSFSTEDVVSLISPEEHSFQKHILLFNISIPRYEEVTRAELRIFISCHKEVGSPSRLEGNMVIYDVLDGDHWENKESTKSLLVSHSIQDCGWEMFEVSSAVKRWVKADKMKTKNKLEVVIESKDLSGFPCGKLDITVTHDTKNLPLLIVFSNDRSNGTKETKVELREMIVHEQESVLNKLGKNDSSSEEEQREEKAIARPRQHSSRSKRSIGANHCRRTSLHVNFKEIGWDSWIIAPKDYEAFECKGGCFFPLTDNVTPTKHAIVQTLVHLQNPKKASKACCVPTKLDAISILYKDDAGVPTLIYNYEGMKVAECGCR