DSC2

Disease resistance-like protein DSC2

1210 amino acids

TIR-NB-LRR receptor-like protein involved in plant defense. Acts as a trigger of hypersensitive response (HR). Functions as guard of CAMTA3, a negative regulator of immunity, during pathogen infection.

Belongs to the disease resistance NB-LRR family.

137.786 kDa

MAIAEVIGFFTLVCVIWYWVYKKHKNLQLKICRSSIESSSSSSSLSSPPSLSSPISRTWTHQVFPSFRGEDVRKGFLSHIQKEFKSKGIVPFIDDEMKRGESIGPGLFQAIRESKIAIVLLSKNYASSSWCLNELVEIMNCREEIGQTVMTVFYQVDPSDVRKQTGDFGKAFKKTCVGKTQEVKQRWSRALMDVANILGQDSRKWDKEADMIVKVAKDVSDVLSYTPSRDFDDYVGIRPHITRINSLLCLESSDVRMIGILGPPGIGKTTIARVLYDQISEKFQFSAFIENIRLSYWKGWHDEGNLDFPVEIMTGDRQRKLNLQRRLLSELFNQKDIQVRHLGAVQERLRDHKVLVILDGVDQLEQLTALAKETQWFGYGSRIIITTQDQRLLRAHEINHVYKVDLPATDEALQIFCLYAFGQKFPYDGFKKLAREFTALAGELPLGLRVLGSYLRGMSLEEWKNALPRLRTSLDGEIEKTLRFAYNVLSDKDKSLFLHIACLFNGCQVNHVKQWLANSSLDVNHGFEVLSNKSLISTDMGLVRMHSLLQQLGVDIVRKQSIGEPEKRQFLVDVNEISDVITDNTGTGTILGIMLHVSKIEDVLVIEETVFDRMTNLQFLILDECLRDKLNLPLGLNCLPRKIRLLRWDYCPLSIWPSKFSAKFLVELIMRANKFEKLWEGIQPLKNLKRMELGDARNLKEIPDLSNATNLESLLLSFCTSLLEIPSSIRGTTNLKELDLGGCASLVKLSSCICNATSLEELNLSACSNLVELPCALPGDSNMRSLSKLLLNGSSRLKTFPEISTNIQELNLSGTAIEEVPSSIRLWSRLDKLDMSRCKNLKMFPPVPDGISVLNLSETEIEDIPPWVENLSQLRHFVMIRCKKLDNISLSRISKMEGVHCLQITRGDEDVSGDSIVNIRWYSNFPNQWTLQSDMLQICLPELVYTSPVSLHFISNEFKTIPDCIKNLSQLHQLSFYRCHKLVSLPQLSDCLSSLDAENCVSLETIDGSFHNPDIRLNFLNCNNLNQEARELIQKSVCKHALLPSGEVPAYFIHRAIGDSVTIHLKERHLPLYLIFKASLVLFNDDEINYDYDDDDDDDYDEEVIVYGDYDSYPHSDDYTKQETMRLSCRVEGKQNGLTIQYGSSVHLLPTPHRYTEHVYIFEASFSLGECNSPEAESELVFDFKVHDYFWAIKECGLRLLELPHAHGDD

Dsc2

Desmocollin-2

902 amino acids

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

99.961 kDa

MAAVGSMRSGSPAFGLGHLLTLAILALASDACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIVHLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREISVHLEGPVEVLNKRPHTEKVLSRAKRRWAPIPCSMLENSLGPFPLFLQQIQSDTAQNYTIYYSIRGPGVDKEPLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDNYPIFTQKLYSFTVQENSRIGSIVGEVCATDLDEPDTMHTRLRYSILEQSPSPPMLFTMHPSTGVITTTSAQLDRELIDKYQLLIKVQDMDGQYFGLHTTAKCIITIEDVNDNLPTFTRTTYVTSVEENTVNVEILRLTVQDKDLVNSPNWRANYTILKGNENGNFKIVTDPKTNEGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASSKSPMSTATVTVTVTNQDEGPECIPPMQTVRIQENVPVGTRNDGYKAYDPETRSSSGIRYRKLSDPRGWVTVNEDSGSITIFRALDREAETVRNGIYNITVLALDADGRSCTGTLGIILEDVNDNGPFIPKQTVVICKATMSSAEIVAVDLDDPVNGPPFDFSLESSDSEVQRMWRLTRINDTAARLSYQNDPSFGSYAVPIRVTDRLGLSSVTTLNVLVCDCITESDCTLRSGERTGYADVRLGPWAILAILLGIALLFCILFTLVCSVSRASKQQKILPDDLAQQNLIVSNTEAPGDDKVYSTNGLTTQTMGASGQTAFTTMGTGVKSGGQETIEMVKGGQQTLDSRRGAGYHHHTLDPCRGGHVEVDNYRHTYSEWYNFIQPRLGDKVQFCHTDDNQKLAQDYVLTYNYEGKGSAAGSVGCCSDLQEEDGLEFLDHLEPKFRTLAEVCAKR

DSC2

Desmocollin-2

901 amino acids

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

99.962 kDa

MEAARPSGSWNGALCRLLLLTLAILIFASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKWAILAILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSERQEEDGLEFLDNLEPKFRTLAEACMKR

DSC2

Desmocollin-2

863 amino acids

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

95.875 kDa

single

KFIGRVNLKECFKSATLIHSSDPDFQILEDGSVYTTHAILLSSEKSSFTILLSNTETQEEKEILVLLEHQTKVLKKRHSQEKVLRRAKRRWAPIPCSVPENSLGPFPLFLQQIQSDTAQNYTIYYSISGPGVDKEPRNLFYVERDTGNLFCTASIDRETYPLFELVAFATTPDGYTPEYPLTLVIRIEDENDNAPIFTETSYSFEVFENSKVGTTVGQVCATDQDEPDTLHTRLKYSIIEQFPALPTLFSMHPTTGVITTSSSKLDRELIDKYQLKIKVQDMDGQYFGLQTTAICIINIEDVNDNLPTFTRSSYVASVEENRIDVEILRVAVRDKDLINTANWRANYTILKGNEDGNFKIVTDSQTNEGVLCVVKPLNYEEKQQVTLEIGVVNEAPYTGTSRSTTNMATVTVNVQNQDEGPECDPRVQTVRIKENVPVGTKTIGYKAYDPETGSSSGIRYKKSSDPEGWVDVDKNSGVITILKRLDREARSGVYNISIIASDKDGRTCNGVLGIVLEDVNDNGPVIPQRTVVICKTVMSSAEIVAVDPDEPIHGPPFDFSLEGVSDSEVLRMWRLTKVNDTAARLSYLNDLRFGKYTVPVRVTDRLGQSLVTQLVVILCDCVTPNDCSFRPVSRTGNREVILGKWAILAILLGIALLFCILFTLVCGATTGADKKPKVFPDDLAQQNLIVSNTEAPGDDKVYSTNDFTTHAVGGSAHGIGGTLGSRVKNGGQETIEMVKGGHQTMESCQETGHDHTLERCKEGGQHTLDSCRGGPVATDNCKYTYSEWYTYTQPRLGEKVQQCDQDNTHMQAQDYVLTYNYEGRGSAAGSVGCCSERQEEDGLEFLDHLGPKFRTLAETCMKR

dsc2

DSC E3 ubiquitin ligase complex subunit 2

372 amino acids

Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.

42.239 kDa

MSSANIVPSNMGITKFLLLTISTSSVVAGVFALKPFFHINFGLHLLSHYQYWRILLWQFIYWNSTEVFQALFIIYQARDVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLFKNLDYIQPGPTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFYHLSLLPGTSWRLPIRFVKPALSPTHVFIRPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDINTVQTIMQTSRAQAIQALSQTNDVQRAVELLLEQTADY