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DSC1

Gene
DSC1
Protein
Disease resistance-like protein DSC1
Organism
Arabidopsis thaliana
Length
1219 amino acids
Function
TIR-NB-LRR receptor-like protein involved in plant defense. Acts as a trigger of hypersensitive response (HR). Functions as guard of CAMTA3, a negative regulator of immunity, during pathogen infection.
Similarity
Belongs to the disease resistance NB-LRR family.
Mass
138.416 kDa
Sequence
MESSSPSSAEFDVFLSFRGFDTRNNFTGHLQKALRLRGIDSFIDDRLRRGDNLTALFDRIEKSKIAIIVFSTNYANSAWCLRELVKILECRNSNQQLVVPIFYKVDKSDVEKQRNSFAVPFKLPELTFPGVTPEEISSWKAALASASNILGYVVKEISTSEAKLVDEIAVDTFKKLNDLAPSGNEGLVGIESRLKNLEKLLSWEDLDTVHIIGIVGMVGIGKTTLADCLYGRMRGQFDGSCFLTNIRENSGRSGLESLLQKLFSTVLNDRDLEIGAPGNAHERFERRLKSKRLLIVLDDVNDEKQIRYLMGHCKWYQGGSRIIITTRDSKLIETIKGRKYVLPKLNDREALKLFSLNAFSNSFPLKEFEGLTNMVLDYAKGHPLALKVLGSDLCERDDLYWEAKLDRLKSRSHGDIYEVLETSYEELTTEQKNVFLDIACFFRSENVDYVTSLLNSHGVDVSGVVKDLVDKCLITLSDNRIEMHDMLQTMAKEISLKVETIGIRDCRWLSRHGNQCQWHIRLWDSEDICDLLTEGLGTDKIRGIFLDTSKLRAMRLSAKAFQGMYNLKYLKIYDSHCSRGCEAEFKLHLRRGLSFLPNELTYLHWHGYPLQSIPLDFDPKNLVDLKLPHSQLEEIWDDEKDVGMLKWVDLSHSINLRQCLGLANAHNLERLNLEGCTSLKKLPSTINCLEKLIYLNLRDCTSLRSLPKGIKTQSLQTLILSGCSSLKKFPLISENVEVLLLDGTVIKSLPESIQTFRRLALLNLKNCKKLKHLSSDLYKLKCLQELILSGCSQLEVFPEIKEDMESLEILLMDDTSITEMPKMMHLSNIKTFSLCGTSSHVSVSMFFMPPTLGCSRLTDLYLSRCSLYKLPDNIGGLSSLQSLCLSGNNIENLPESFNQLNNLKWFDLKFCKMLKSLPVLPQNLQYLDAHECESLETLANPLTPLTVGERIHSMFIFSNCYKLNQDAQASLVGHARIKSQLMANASAKRYYRGFVPEPLVGICYPATEIPSWFCHQRLGRSLEIPLPPHWCDINFVGLALSVVVSFKDYEDSAKRFSVKCCGNFENKDSSFTRFDFTLAGWNEPCGSLSHESRKLTSDHVFMGYNSCFLVKNVHGESNSCCYTKASFEFYVTDDETRKKIETCEVIKCGMSLMYVPEDDDCMLLKKTNIVQLSLKSGPSCSYDLDDVMDDVRPKRGLCQFVGGEEPGCKRRKEEKITVR

Gene
DSC1
Protein
Desmocollin-1
Organism
Homo sapiens
Length
894 amino acids
Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Mass
99.987 kDa
Sequence
MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSFEMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEHKHCEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCIKK

Gene
DSC1
Protein
Desmocollin-1
Organism
Bos taurus
Length
893 amino acids
Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Mass
99.648 kDa
Sequence
MAVASAAPGSIFWKQLLFSLLVLILFCDACQKISLQVPSHLRAEALVGKVNLKECLQSASLILSSDPDFRILEDGSIYTTHDLVLSSGKSFSILLSDSQGQGQKEIEIILEAGGKKVPKRHMKDAVLRRTKRRWAPIPCSLMENSLGPFPQHVQQVQSDAAQNYTIFYSISGPGVDKEPFNLFFIEKDTGDIFCTRSIDREQYQEFPIYAYATTADGYAPEYPLPLVFKVEDDNDNAPYFENKLTVFTVPENCRTGTSVGKVTAIDLDEPDTLHTRLKYKILQQIPNNPRHFTVHPDTGVITTTTPLLDREKCDTYKLIMEVRDMGGQPFGLFNTGTITISLEDENDNAPYFTETSYTVEVEENRIDVEILRMAVHDHDLPNTPHSRAVYQILQGNENGTFKISTDPNTNEAVLCVVKPLNYEVNRQVVLQIGVLNEAQFAKAVNSKTTTTMCTTVVTVKVKDHDEGPECQPPVKVIQSEDCLPTGTELLGYKAVDPERGTGEGLRYKKIQDEDNWFEINEYTGDLKTVKVLDRESTFVKNNQYNVSVIAFDADGRSCTGTLVVFLEDKNDHPPQIKQEELTICRHDKDYVVLEPTDQDGPDNGPPFQFILDNSASKLWTVETRDGKTAILRGRQDLDYDYYTVPIQIKDRHGASATHILPVRVCDCTIPSECRMPSKLSREAALANVFLGKWAILAMVLGSVLLLCILFTCFCVTVKKTVKKCFPEDVAQQNLIVSNTEGPGEEVMDANIRLPTQTSNVCDTSISVGTLGGQGVKTQQSFEMVKGGYTLDANKGGGHQTLESVKGVTDTGRYTYSDWHNFTQPRLGEKVYLCGQDEEHKLCEDYVRSYSYEGKGSVAGSVGCCSDRQEEEGLDFLDHLEPKFRTLAKTCVKK

Gene
Dsc1
Protein
Desmocollin-1
Organism
Mus musculus
Length
886 amino acids
Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Mass
98.938 kDa
Sequence
MAVACAAPGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQSDAAQNYTIFYSISGPGVDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDQPKHFSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPYFTQTSYTTEVEENRIDVEILRMVVHDQDLPNTPHSKAVYTILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLNEAQFTNAANAQPPTMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMVGDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATDTAGRSCTGTLVVLLEDFNDHPPQIDKEVTICQQEKDFAVLEPIDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTTPTECRMAVKEERDAKPNIILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTANICDTSMSVGTLGGQGIKTQQSFEMVKGGHTLESHKGGVLGAAEPGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCEDYVRPYNYEGKGSMAGSVGCCSDRQEEEGLEFLDQLEPKFRTLAKTCVKK

Gene
dsc1
Protein
DSC E3 ubiquitin ligase complex subunit 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
695 amino acids
Function
Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation.
Mass
79.185 kDa
Sequence
MDRRRWVPSTPVVTLLLLFMLFAPAPRLPSRNGESSEKSIKAEKRAFSEIKNATFLNIPERVEHSLTFPTEIWETRDGLFEEPVGKGDSHLNHTSVMTGNWNILPYPSFGKVSPNVTWHTTLRNIVMSQSGRFSANLYEYVDGNSDGISFVLNLENNNDTSVYHMTFHGDRVKPINVFLGSTDVTPNFGGVDVIPWLLKDSPYKDAPPLDGTEYFPLLQNRSLERIETRLQDAQTVGWSPLVFEEEEVTCSAFVFLHNKNTGLDKETLKAIENEFYHPQGVSTQKMPEVFVSGLVYSPDCNVAFTFSNTKGPRNFVLENHLVRFSSLYIFIVLSQIFVLLRQMRINSPSHVQRLSFLTIAMQAGLDAYIAIFFLSTNAVIEKGYLPFVSVAFLSLVPSVMFTMRYLALILRVQNSNMPPPAPRPVTNNSSNNNTNQSNASNENSPNAPSAANDNTETTTVNPPQEDDQPMTQHERDQRDWSAVCLRFYFIILVVCIASLYSAFWPVIYRFYFISALIFTSYSFWIPQIIQNVKQGTSRSFTWTYILGASVLRLYLPLAIFIDSELILGFPPKYFFALGLVLWMLFQVLVLLVQDTLGPRFFLPKKFFLSSPVYDYHPVIQQDDLEAFMRDANVCPICMQPIELVSTGSTLNPASMMVRRNYMLTPCHHLYHRQCLLQWMETRSICPVCRCHLPAV