Protein
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
Similarity
Belongs to the class II aldolase/RraA-like family.
Sequence
MTDFIPTTDLSDAQPQAQVAAPVLRDFGGRTRFQGAAVTLRISENNPLVRQTLQTPGAGRVLVVDGGGSLNCALLGGNLGVFGVENGWEGVIIHGCVRDTAELRELDLGIRALAAHPRRSGKLEEGERDVPVTFAGVTIRPGDHVVADEDGWLVLGAESP