Protein
Probable inactive DNA (cytosine-5)-methyltransferase DRM3
Organism
Arabidopsis thaliana
Function
Catalytically inactive DNA methyltransferase that acts as regulatory factor for DRM2-mediated DNA methylation. Required for maintenance of non-CpG DNA methylation. Required for normal establishment and maintenance of RNA-directed DNA methylation (RdDM) and accumulation of specific repeat-associated small interfering RNAs (siRNAs) (PubMed:21060858, PubMed:25316414, PubMed:25561521). Required for nucleolus organizer region (NOR) nuclear organization during interphase (PubMed:25316414). Acts downstream of the production of siRNAs. May promote RNA polymerase V (Pol V) transcriptional elongation or assist in the stabilization of Pol V transcripts (PubMed:25561521).
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. DRM-methyltransferase family.
Sequence
MADMRRRNGSGGSSNHERNEQILFPKPETLDFDLPCDTSFPQQIGDNAASSSGSNVKSLLIEMGFCPTLVQKAIDENGQDDFELLLEILTKSTETEPPGPSFHGLMEPKPEPDIEYETDRIRIALLTMKFPENLVDFALDRLGKDTPIDEMVDFIVAAQLAEKYAEESEDSLDGAEINEEDEDVTPVTARGPEVPNEQLFETMDKTLRLLEMGFSNDEISMAIEKIGTKGQISVLAESIVTGEFPAECHDDLEDIEKKVSAAAPAVNRTCLSKSWRFVGVGAQKEDGGGGSSSGTANIKPDPGIESFPFPATDNVGETSRGKRPKDEDENAYPEEYTGYDDRGKRLRPEDMGDSSSFMETPWMQDEWKDNTYEFPSVMQPRLSQSLGPKVARRPYFFYGQLGELSPSWWSKISGFLFGIHPEHVDTRLCSALRRTEGYLHNLPTVNRFNTLPNPRLTIQDAMPHMRSWWPQWDIRKHFNSGTCSNMKDATLLCERIGRRIAECKGKPTQQDQTLILRHCHTSNLIWIAPNILSPLEPEHLECIMGYPMNHTNIGGGRLAERLKLFDYCFQTDTLGYHLSVLKSMFPQGLTVLSLFSGIGGAEIALDRLGIHLKGVVSVESCGLSRNILKRWWQTSGQTGELVQIEEIKSLTAKRLETLMQRFGGFDFVICQNPSTPLDLSKEISNSEACEFDYTLFNEFARVTKRVRDMM