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DRG1

Gene
DRG1
Protein
Developmentally-regulated G-protein 1
Organism
Arabidopsis thaliana
Length
399 amino acids
Function
Binds GDP and GTP, and has low GTPase activity. May interact with phosphatidic acid (PA).
Similarity
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Mass
44.639 kDa
Sequence
MGIIERIKEIEAEMARTQKNKATEYHLGQLKAKIAKLRTQLLEPPKGASGGGEGFEVTKYGHGRVALIGFPSVGKSTLLTMLTGTHSEAASYEFTTLTCIPGVIHYNDTKIQLLDLPGIIEGASEGKGRGRQVIAVAKSSDLVLMVLDASKSEGHRQILTKELEAVGLRLNKTPPQIYFKKKKTGGISFNTTAPLTHIDEKLCYQILHEYKIHNAEVLFRENATVDDFIDVIEGNRKYIKCVYVYNKIDVVGIDDVDRLSRQPNSIVISCNLKLNLDRLLARMWDEMGLVRVYSKPQGQQPDFDEPFVLSSDRGGCTVEDFCNHVHRTLVKDMKYALVWGTSTRHNPQNCGLSQHLEDEDVVQIVKKKERDEGGRGRFKSHSNAPARIADREKKAPLKQ

Gene
drg1
Protein
Developmentally-regulated GTP-binding protein 1 homolog
Organism
Dictyostelium discoideum
Length
370 amino acids
Similarity
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Mass
40.959 kDa
Sequence
MSLVQKIKEVEDEMARTQKNKATSFHLGVLKAKLAKYKRELLLGPSKGAAAGAGEGFDVSKAGDARVGLIGFPSVGKSTLLTKLTGTSSEVASYEFTTLTCIPGVINYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVGRTCNLILIVLDAMKPLVHKKIIERELDGFGIRLNKQPPPITFKKKEKGGINFSHTPNVNPTQLDSETVKAICAEYKIHNADVILRGNCTVDEFIDVIEGNRIYVPCIYVLNKIDAISIEELDLLDKIPHYVPISSHLEWNLDALLDKIWEYLKLIRVYTKPKGLIPDYNEPVVIRGGEEASIETFCNHIHNSIIRQFRYALVWGSSAKHNPQRCGKDHVLADEDIVQIVKK

Gene
DRG1
Protein
Developmentally-regulated GTP-binding protein 1
Organism
Bos taurus
Length
367 amino acids
Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.
Similarity
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Mass
40.542 kDa
Sequence
MSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK

Gene
DRG1
Protein
Developmentally-regulated GTP-binding protein 1
Organism
Homo sapiens
Length
367 amino acids
Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).
Similarity
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Mass
40.542 kDa
Sequence
MSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK

Gene
Drg1
Protein
Developmentally-regulated GTP-binding protein 1
Organism
Mus musculus
Length
367 amino acids
Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions.
Similarity
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Mass
40.512 kDa
Sequence
MSGTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK

Gene
drg1
Protein
Developmentally-regulated GTP-binding protein 1
Organism
Xenopus laevis
Length
367 amino acids
Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (By similarity). Binds to microtubules and promotes microtubule polymerization and bundling. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).
Similarity
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Mass
40.415 kDa
Sequence
MSGTLARIAEIEAEMARTQKNKATAYHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVVRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNKQPPNIGFKKKDKGGINLTATCAQSELDNDTVKSILAEYKIHNADITLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLQLVRIYTKPKGQLPDYTSPVVLPCSHTAAEDFCTKIHKNLIKEFKYALVWGSSVKHNPQKVGKDHVLEDEDVIQIVKK

Gene
DRG1
Protein
Dermaseptin DRG1
Organism
Phyllomedusa bicolor
Length
81 amino acids
Function
Has antimicrobial activity.
Similarity
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
Mass
8.756 kDa
Sequence
MASLKKSLFLVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEMKRGLWSNIKTAGKEAAKAALKAAGKAALGAVTDAVGEQ