Protein
Diphthamide biosynthesis protein 4
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Sequence
MIKSQTPRHDYYHILNLPFTTPPAALSKQQLKIAYHKALLKHHPDKAISVAATPARTHTHDTKTAYRSSPDRNADTSPTFTIDEITAAYKTLSDPALRAEYDRVLRLERVTAGKGDKGAEAAFHTGLEVVDLEDLVCEEMGDGEGLLCWYRGCRCGDERGFMVTEKDLEKEAEHGEVVIGCRGCSLWMKILFAMEEGDG