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DPH4

Gene
dph4
Protein
Diphthamide biosynthesis protein 4
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
199 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
22.152 kDa
Sequence
MIKSQTPRHDYYHILNLPFTTPPAALSKQQLKIAYHKALLKHHPDKAISVAATPARTHTHDTKTAYRSSPDRNADTSPTFTIDEITAAYKTLSDPALRAEYDRVLRLERVTAGKGDKGAEAAFHTGLEVVDLEDLVCEEMGDGEGLLCWYRGCRCGDERGFMVTEKDLEKEAEHGEVVIGCRGCSLWMKILFAMEEGDG

Gene
dph4
Protein
Diphthamide biosynthesis protein 4
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
188 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
20.548 kDa
Sequence
MTQTSAAPTTTPSFYEILNLPFPSTGLSKQQLKIAYHKALLKHHPDKAVAVAKENLPSSNHGPAQPPSNQKITIDAITTAYKTLSDPVQRAEYDRVLRLDRNRVNGAGDKNGNGTVFHTGLEVVDLEDLDCDEGGDEAMWYMACRCGDERGFSLSESDLEREADSGEIVVGCRGCSLYTKVLFAVQDD

Gene
DPH4
Protein
Diphthamide biosynthesis protein 4
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
188 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
20.774 kDa
Sequence
MTSSQSISSSADTATHYQVLNITSALLDTQHDSTPLIKRAYHRALLRNHPDKVANSDPSSVFFTVDQITTALNVLSSPSARVAYDAALRVSRPTGAAGRDGSFQTGVENVDLDDLAFDEDQECWYRPCRCGNEHSYEFREADLEEVSEEGELVVGCLDCSLWLRVHFAVLDENEDDVQPSSTTSKDKI

Gene
DPH4
Protein
Diphthamide biosynthesis protein 4
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
175 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
19.869 kDa
Sequence
MTVKSKSRISHYEVLGVPVDASTDEIKLTYRKMLLTLHPDKSKTVPIDSTIKIRSGVSINQIQEAYRVLSNDQLRAAYNRALNDSNKLAGFNNFGDGLDEFNLDEFEFNEEKLEYVMTCPRCQSGGGFVLSEDMLEECIEDGLTESEEQGYQVLTQCTACSLWLKVNFFINDEEE

Gene
dph4
Protein
DPH4 homolog
Organism
Dictyostelium discoideum
Length
170 amino acids
Function
Stimulates the ATPase activity of several Hsp70-type chaperones. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
19.882 kDa
Sequence
MTNSSNNSNKCENKNYYEILKVSIDADIEEIKKSYRKLALLYHPDKLNKEENIEENINNFSNCLVNNNNNNNNSNTKDFNDIQIAWETLKDDLLRKQYDSLLLEQKRQKYSVSDEIDLDDMEFIEENSEYVYPCRCGDHYIITEDQLSEGSDVVCCSGCSLSIKVIYQME

Gene
DPH4
Protein
Diphthamide biosynthesis protein 4
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
168 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
19.593 kDa
Sequence
MDPYIEDRDIQKRSHYKVLGVVPTCNDLDIKSAYKEMLLAHHPDKNGNASTTINSIQEAYKTLIDPELRDQYDDSLKRSIQRQGFNITGDGLDIYCLDDFEMEEEEECKWLKDCPRCQFPKSIKFKESDLIENGTEDGDNGFDIIVQCESCSLWIKVKYYEINEEDDE

Gene
DPH4
Protein
Diphthamide biosynthesis protein 4
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
163 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
18.232 kDa
Sequence
MNHYTILGLSEPPHVPELTSADLKTAYKQALLKNHPDKLQEREAYTGSVQITAITTAYACLSNSKLKKEYDLSLKNGANGVKSGPGSDVFDLTELEEREDADGMFSWYKPCRCGEAGGYVLTEEHLENNEKYYEGVDVQFHEIVVQCGTCSLWITVQYGVEEE

Gene
DPH4
Protein
Diphthamide biosynthesis protein 4
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
162 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
18.411 kDa
Sequence
MQRSFYEILGIESDASNIEIKRAYRAMLLETHPDKSGLNYNSNGNNTSSHSVTDIQEAYQTLIDQDLRKKYDEELAESFKKLGFHNAGDGLDLFSLDLFDYSGDEQSFSMNCPRCQITDGFQLTEDALEEHAIDYEGGGYFVLVQCSACSLWLKVLFDVMEE

Gene
DPH4
Protein
Diphthamide biosynthesis protein 4
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
156 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
17.062 kDa
Sequence
MDGSHYDILGIAVDAEPLEVRQAYRQRLLEAHPDKQGGVDKGAVTRIQQAYRVLSDPTQRSAYDGELAVQIAATGVHGRADALDEHSLDDFEYNEQQGVFTMACPRCSSAEGFELPEQALEENATARPGGGMQVIVQCAACSLWLKVDFDIVYTSE

Gene
dph4
Protein
Diphthamide biosynthesis protein 4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
139 amino acids
Function
Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
16.097 kDa
Sequence
MNHYSVLNLKDGKTYTDDEIKEAYRKALLLFHPDKCKEKPSVVYTIDQVKEAYQVLSSEKDRQQYQIKQEEESSHYYSIVDLSEFEELDNGSYYYPCRCGDLGGYVVTEDDLENNRSVVPCMGCSLTIQVDYEIAESDS