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DNAJC24

Gene
DNAJC24
Protein
DnaJ homolog subfamily C member 24
Organism
Bos taurus
Length
149 amino acids
Function
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity).
Similarity
Belongs to the DPH4 family.
Mass
17.135 kDa
Sequence
MMAFEQIPKKDWYSILGADPSASVSDLKQKYQKLILMYHPDKQSADAPAGSVEECIQKFIEIDQAWKILGNEETKKEYDLQRHEDDLRNMGPVDARIYLEEMSWNEDDHSFSLSCRCGGKYSVSKDEAEEVTLISCDTCSLIIELLHYC

Gene
DNAJC24
Protein
DnaJ homolog subfamily C member 24
Organism
Homo sapiens
Length
149 amino acids
Function
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Similarity
Belongs to the DPH4 family.
Mass
17.139 kDa
Sequence
MMAVEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEIDQAWKILGNEETKREYDLQRCEDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN

Gene
Dnajc24
Protein
DnaJ homolog subfamily C member 24
Organism
Mus musculus
Length
148 amino acids
Function
The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).
Similarity
Belongs to the DPH4 family.
Mass
16.922 kDa
Sequence
MALEQTLKKDWYSILGADPSANMSDLKQKYQKLILLYHPDKQSADVPAGTMEECMQKFIEIDQAWKILGNEETKKKYDLQRHEDELRNVGPVDAQVRLEEMSWNQGDESFFLSCRCGGKYTVSKDEAQEATLISCDACSLIVELLHQS