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DNAH12

Gene
DNAH12
Protein
Dynein heavy chain 12, axonemal
Organism
Homo sapiens
Length
3092 amino acids
Function
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Similarity
Belongs to the dynein heavy chain family.
Mass
356.942 kDa
Sequence
MSDANKAAIAAEKEALNLKLPPIVHLPENIGVDTPTQSKLLKYRRSKEQQQKINQLVIDGAKRNLDRTLGKRTPLLPPPDYPQTMTSEMKKKGFNYIYMKQCVESSPLVPIQQEWLDHMLRLIPESLKEGKEREELLESLINEVSSDFENSMKRYLVQSVLVKPPVKSLEDEGGPLPESPVGLDYSNPWHSSYVQARNQIFSNLHIIHPTMKMLLDLGYTTFADTVLLDFTGIRAKGPIDCESLKTDLSIQTRNAEEKIMNTWYPKVINLFTKKEALEGVKPEKLDAFYSCVSTLMSNQLKDLLRRTVEGFVKLFDPKDQQRLPIFKIELTFDDDKMEFYPTFQDLEDNVLSLVERIAEALQNVQTIPSWLSGTSTPVNLDTELPEHVLHWAVDTLKAAVHRNLEGARKHYETYVEKYNWLLDGTAVENIETFQTEDHTFDEYTEFIEKFLSLASEIMLLPQWIHYTMVRLDCEDLKTGLTNKAKAFANILLNDIASKYRKENECICSEFEAIKEHALKVPETTEEMMDLISYVEKARTVGIEELILRIQESKRQMSYFLDVFLFPQEDLALNATVLMWPRKINPIFDENDELIENAKHKKENELMAKREKLILEIEKESRRMEEFTEFAELERMQQYVTDVRQLQKRIQESEEAVQFINKEEELFKWELTKYPELDKLKVNIEPYQKFFNFVLKWQRSEKRWMDGGFLDLNGESMEADVEEFSREIFKTLKFFQTKLKKELQEKRKAARKRSLEEEKIEEEPKDNATITMCRMRARHWKQISEIVGYDLTPDSGTTLRKVLKLNLTPYLEQFEVISAGASKEFSLEKAMNTMIGTWEDIAFHISLYRDTGVCILSSVDEIQAILDDQIIKTQTMRGSPFIKPFEHEIKAWEDRLIRIQETIDEWLKVQAQWLYLEPIFCSEDIMQQMPEEGRQFQTVDRHWRDIMKFCAKDPKVLAATSLTGLLEKLQNCNELLEKIMKGLNAYLEKKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFEGIAKLEFLPNLDIKAMYSSEGERVELIALISTSAARGAVEKWLIQVEDLMLRSVHDVIAAARLAYPESARRDWVREWPGQVVLCISQMFWTSETQEVISGGTEGLKKYYKELQNQLNEIVELVRGKLSKQTRTTLGALVTIDVHARDVVMDMIKMGVSHDTDFLWLAQLRYYWENENARVRIINCNVKYAYEYLGNSPRLVITPLTDRCYRTLIGAFYLNLGGAPEGPAGTGKTETTKDLAKALAVQCVVFNCSDGLDYLAMGKFFKGLASSGAWACFDEFNRIELEVLSVVAQQILCIQRAIQQKLVVFVFEGTELKLNPNCFVAITMNPGYAGRSELPDNLKVLFRTVAMMVPNYALIAEISLYSYGFLNARPLSVKIVMTYRLCSEQLSSQFHYDYGMRAVKAVLVAAGNLKLKYPNENEDILLLRSIKDVNEPKFLSHDIPLFNGITSDLFPGIKLPEADYHEFLECAHEACNVHNLQPVKFFLEKIIQTYEMMIVRHGFMLVGEPFAAKTKVLHVLADTLTLMNEHGYGEEEKVIYRTVNPKSITMGQLFGQFDPVSHEWTDGIVANTFREFALSETPDRKWVVFDGPIDTLWIESMNTVLDDNKKLCLMSGEIIQMSPQMSLIFETMDLSQASPATVSRCGMIYLEPSQLGWEPLVSSWLNSLKGPLCEPEYQALLRGLFAWLIPPSLNQRVELFQLNYLYTTIVSKILKILITFRISNYFKYVPLKTQCTFIKFFLHQQACFIFSLIWSIGGSCDTDGRRVFDTFIRLIILGKDDENPVPDSVGKWECPFDEKGLVYDYMYELKNKGRWVHWNELIKNTNLGDKQIKIQDIIVPTMDTIRYTFLMDLSITYAKPLLFVGPTGTGKSVYVKDKLMNHLEKDQYFPFYINLSARTSANQVQNIIMARLDKRRKGVFGPPMGKKCIIFIDDMNMPALEKYGAQPPIELLRQFFDCGHWYDLKDTSKITLVDIELIAAMGPPGGGRNPVTPRCIRHFNICSINSFSDETMVRIFSSIVAFYLRTHEFPPEYFVIGNQIVNGTMEIYKQSVENLLPTPTKSHYTFNLRDFSRVIRGCLLIERDAVANKHTMIRLFVHEVLRVFYDRLINDDDRRWLFQLTKTVIKDHFKESFHSIFSHLRKQNAPVTEEDLRNLMFGDYMNPDLEGDDRVYIEIPNIHHFSDVVDQCLDEYNQTHKTRMNLVIFRYVLEHLSRICRVLKQSGGNALLVGLGGSGRQSLTRLATSMAKMHIFQPEISKSYGMNEWREDMKSFIAVPVTNRIVDNKSKILEKRLRYLNDHFTYNLYCNICRSLFEKDKLLFSFLLCANLLLARKEIEYQELMFLLTGGVSLKSAEKNPDPTWLQDKSWEEICRASEFPAFRGLRQHFCEHIYEWREIYDSKEPHNAKFPAPMDKNLNELQKIIILRCLRPDKITPAITNYVTDKLGKKFVEPPPFDLTKSYLDSNCTIPLIFVLSPGADPMASLLKFANDKSMSGNKFQAISLGQGQGPIAAKMIKAAIEEGTWVCLQNCHLAVSWMPMLEKICEDFTSETCNSSFRLWLTSYPSSKFPVTILQNGVKMTNEPPTGLRLNLLQSYLTDPVSDPEFFKGCRGKELAWEKLLFGVCFFHALVQERKKFGPLGWNIPYGFNESDLRISIRQLQLFINEYDTIPFEAISYLTGECNYGGRVTDDWDRRLLLTMLADFYNLYIVENPHYKFSPSGNYFAPPKGTYEDYIEFIKKLPFTQHPEIFGLHENVDISKDLQQTKTLFESLLLTQGGSKQTGASGSTDQILLEITKDILNKLPSDFDIEMALRKYPVRYEESMNTVLVQEMERFNNLIITIRNTLRDLEKAIKGVVVMDSALEALSGSLLVGKVPEIWAKRSYPSLKPLGSYITDFLARLNFLQDWYNSGKPCVFWLSGFFFTQAFLTGAMQNYARKYTTPIDLLGYEFEVIPSDTSDTSPEDGVYIHGLYLDGARWDRESGLLAEQYPKLLFDLMPIIWIKPTQKSRIIKSDAYVCPLYKTSERKGTLSTTGHSTNFVIAMLLKTDQPTRHWIKRGVALLCQLDD

Gene
Dnah12
Protein
Dynein heavy chain 12, axonemal
Organism
Rattus norvegicus
Length
3092 amino acids
Function
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Similarity
Belongs to the dynein heavy chain family.
Mass
357.248 kDa
Sequence
MSDPNKTAITAEKEALNLKLPPIVHPPKNIGVDTPKQSELLNYRRSKEQQKKINQLVISAAKKSLDKTLDKRIPPLPEPDFPPTMTSEIKKKGLNYIFMKQCVESSPIVPIQPQWLDHMLMLIPEHLKEGKKREELLGSLINEVSMDFEKSMKRYLVQSVLVKPPVKWLEDEWGPLPESPEGLDYSNPWHSNFVQARSQILANLHIVHPTMKLLLELGYTTFSDIILLDLTGIRDRGPIDCEALRNDLSIQARKAEERIMNTWYPKVINLFTKKEALEGIKPEKVDSFYNCVSILMSNQLKDLLWRTVEEFVRLFDSRYILRLPIFKMELTFDDDKMEFYPTFQDLEDVVLGLIERISETLQTVQTVPSWLSGTTAPVNLDTELPEHVMYWALSTLRIAVHQNLEGVRAHYKTYVTNYNWLLDGTATKMIERFQSENHTFDEYTEFIERFFSLASEIMLLPQWAHYPMVRLDCEDLKTGLTNKAKAFANILLNDIASKHRKENESICSEFETIKEHALRVPETTEEMMELIAFIEKARTTGIQNLAQRIQESKRQMGYFLDTFLLSQEDLNLNASVLLWPSKINPVFDENDELIENSKRTKENELIAKREKLILEIEKESRRMEEFTEFAELDRMQQYVADVRHLQKRIQDSEEAVQFINKEEELFKWELTKYPELEKLKVTIEPYQKFFNFVLKWQRTEKRWMDGGFLDLNGESMEADIDEFSREVFKTLKFFQTKQKKELQEKRKAARKRSLMEEKPEEEPKESPTITMMRARHWKQMSEIVGYDLTPDSGTTLRKVLKLNLTPYLESFEVISAGASKEFSLERAMNAMIATWDDISFHISLYRDTGVYILSSVDEIQAILDDQIIKTQTMRGSPFIKPFENEIKAWEDRLIRIQETIDEWLKVQAQWLYLEPIFCSEDIMQQMPEEGRQFQTVDRHWKDIMKFCAKDPKVLAATSLTGLLEKLQNCNDLLDKIMKGLNAYLEKKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFEGIAKLEFLTNLDIKAMYSSEGERVELISVISTSAARGAVEKWLIQVEDLMLRSIHDVIAASRLAYPESARKDWVREWPGQVVLCVSQMFWTSETQEVISGGNEGLKKYYKELQYQLNDIVELVRGKLSKQTRITLGALVTIDVHARDVVMDMIDMGVSHDTDFQWLAQLRYYWEYENARVRIVNCNVKYAYEYLGNSPRLVITPLTDRCYRTLIGAFYLNLGGAPEGPAGTGKTETTKDLAKALAVQCVVFNCSDGLDYLAMGKFFKGLASSGAWACFDEFNRIELEVLSVVAQQILCIQRAIQQKLEVFVFEGTELRLNPNCFVAITMNPGYAGRSELPDNLKVLFRTVAMMVPNYALIAEISLYSYGFLNAKPLSVKIVMTYRLCSEQLSSQFHYDYGMRAVKAVLVAAGNLKLKYPNENEDILLLRSIKDVNEPKFLSHDIPLFNGITSDLFPGIKLPEADYQEFLECAYEACETQNLQPVKFFLEKIIQTYEMMIVRHGFMLVGEPFAAKTEVLHILADTLTLMNERNYGDEEKVMYRTVNPKSITMGQLFGQFDPVSHEWTDGIVANTFREFALAESPDRKWVVFDGPIDTLWIESMNTVLDDNKKLCLMSGEIIQMSPQMSLIFETMDLSQASPATVSRCGMIYLEPSQLGWEPIVASWLNSLKEPLNELEHQNLLKELFNWLVQPSLEFRRKKCKVTAHRVWLFPTVYSSWVCLILFVLEVSAVSPKCSLKSNCYNLFHQQATFVFSLIWSVGASCDTDGRLAFDNFLRSLVTGKNDKAPMPVFINKWECPFDEKGLVYDYMYELRNRGRWIHWNDLIKSSDIEDRRTKIQDIIVPTMDTIRYTFLMDLCISHAKPLLFVGPTGTGKSVYVKDKLMNHLEKGKYFPFYVNFSARTSANQVQNIIMARLDKRRKGVFGPPMGKKCVVFIDDMNMPSLEKYGAQPPIELLRQFFDCGHWYDLKDTTKITLVDIELIAAMGPPGGGRNAVTPRFIRHFNICTINSFSDETMVRIFSSIMMFYLRTHDFSPEYFVLGHQIVSATMEIYKQSMGNLLPTPAKSHYTFNLRDFSRVIRGCLLIDKEAIESKHTMIRLFVHEVLRVFYDRLINDEDRNWLFLLIKNVIKDHFKESLENVFSHLRRGNSSINEEDLRNLMFGDYMNPDLEGDDRVYIEILNIHQFNEVVDQCLDEYNQTHKRRMNLVVFRYVLEHLSRICRILKQSGGNALLIGLGGSGRQSLTSLATSMAKMQIFQPEISKSYGMNEWREDIKPNLMSVFYATSIRDNLSKILEKRLRYLNDHFTYNLYCNICRSLFEKDKLLFSFLLCANLLLAKKEIEYQELMFLLTGGVSLKSAEKNPDPNWLQDKSWEEICRASELPVFHGLREHFCNHIREWEDIYNSKEPHNMKLPESMDKTLNELQKIIILRCLRPDKITPAITNYVTDKLGKKFVEPPPFDLTKSYLDSNCTIPLIFVLSPGADPMASLLKFANDKSMSGNKFQAISLGQGQGPVATKMITAAIEEGTWVCLQNCHLAVSWMPTLEKICEDFSPEICNPTFRLWLTSYPSPKFPVTILQNGVKMTNEPPTGLRLNLLQSYLSDPISDPEFFNGCPGKELAWEKLLFGVCFFHALVQERKKFGPLGWNIPYGFNESDLRISIRQLQLFINEYDTIPFEAISYLTGECNYGGRVTDDWDRRLLLTMLADFYNSLIIENPHYKFSPSGNYFAPPKGTYDEYIEFIKKLPFTQEPEIFGLHENVDISKDLQQTKLLFESLLLTQGGVKQTGSSGSTDQILLEITEDILTQLPNDFDIEAALRSYPVRYEESMNTVLVQEMERFNNLIITIRNTLRDLKKAIKGVVVMDSALEALSGSLLIGKVPEMWAQRSYPSLKPLGSYITDFLTRLKFLEDWFTMGKPNVFWISGFFFTQAFLTGAMQNYARKYTIPIDLLGYEFEVIPSDNATNPPEDGVYIHGLYLDGARWNRTSGLLAEQHPKLLFDLMPIIWIKPNVKTEIVKTDAYVCPLYKTSERKGTLSTTGHSTNFVIAMLLRTELPAQHWIKRGVALLCQLD

Gene
Dnah12
Protein
Dynein heavy chain 12, axonemal
Organism
Mus musculus
Length
3086 amino acids
Function
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Similarity
Belongs to the dynein heavy chain family.
Mass
356.231 kDa
Sequence
MSDPNKTAIAAEKEALNLKLPPIVQPPKNIGVDTPKQSELLKYRRSKEQQKKINQLVISGAKKSLDKTLDKRIPPLPEPDFPPTMTSEIKKRGLNYIFMKQCVENSPIVPIQSQWLDNMLMLVPEHLKEGEKSEELLGSLIDEVSMDYEKSMKRYLVQSVLVKPPVKWLEDEGGPLPESPEGLDYSNPWHSNFVQARSQILANLHIVHPTMKMLLELGYTAFAKIILLDLTGIRARGPIDCEALRNDLSIQARKSEEKIMNTWYPKVINLFTKKEALEGIKTEKLDSFYNCVSILMSNQLKDLLWRTVEEFIKLFDPRYLNRLPIFKMELTFDDDKMEFYPTFQDLEDVVLGLIERISETLQTVQTVPSWLSGTSSPVNLDTEIPEHVLQWALCTLRTAIQHNLEGAKAHHKTYVTKYNWLLDGTATKMIQRFQAENHTFDEYTEFIEKFFNLASEIMLLPQWAHYPMVRLDCEDLKIGLTNKARAFANILLNDIASKHRKENESICSEFEAIRDHALRVPETTEEMMELIAFVERARTVGILDLALRIQESKRQMSYFLDALLMSQEDLNLNATVLLWPTKITPVFDENDELIENAKHAKENELIAKREKLILEIEKESRRMEEFTEFAELDRMHQYVADVRQLQKRIQESEEAVQFINKEEELFKWELTKYPELEKLKVTIEPYQKFFNFVLKWQRTEKRWMDGGFLDLNGESMEADIDDFSREVFRTLKFFHAKQKKELQERRKAARKRSLMEEKPEEEPKENPTITMMRARHWKQMSEIVGYDLTPDSGTTLRKVLKLNLSPYLESFEVISAGASKEFSLERSMNAMIATWDDISFHISLYRDTGIGILSSVDEIQAILDDQIIKTQTMRGSPFIKPFENEIKAWEDRLIRIQETIDEWLKVQAQWLYLEPIFCSEDIMQQMPEEGRQFQTVDRHWKDIMKFCAKDPKVLAATSLTGLLEKLQNCNDLLEKIMKGLNAYLEKKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFEGIAKLEFLANLDIKAMYSSEGERVELIALISTTAARGAVEKWLIQVEDLMLRSIRDVIAASRLAYPESARKDWVREWPGQVVLCVSQMFWTSETQEIISGGTEGLKKYYKELQYQLNDIVELVRGKLSKQTRITLGALVTIDVHARDVVMDMIEMGVSHDTDFQWLAQLRYYWEYENARVRIINCNVKYAYEYLGNSPRLVITPLTDRCYRTLIGAFYLNLGGAPEGPAGTGKTETTKDLAKALAVQCVVFNCSDGLDYLAMGKFFKGLASSGAWACFDEFNRIELEVLSVVAQQILCIQRAIQQKLEAFVFEGTELRLNPNCFVAITMNPGYAGRSELPDNLKVLFRTVAMMVPNYALIAEISLYSYGFLNAKPLSVKIVMTYRLCSEQLSSQFHYDYGMRAVKAVLVAAGNLKLKYPNENEDILLLRSIKDVNEPKFLSHDIPLFNGITSDLFPGIKLPEADYKEFLECAHETCQTHNLQPVKFFLEKIIQTYEMMIVRHGFMLVGEPFAAKTEVLHVLADTLTLMNERNYGDEEKVMYRTVNPKSITMGQLFGQFDPVSHEWTDGIVANTFREFALAESPDRKWVVFDGPIDTLWIESMNTVLDDNKKLCLMSGEIIQMSPQMSLIFETMDLSQASPATVSRCGMIYLEPSQLGWEPLVASWLNSLKEPLSELEHQNLLKELFDWLVPPSLVFRRKKCKFLSLHDLSKYFKQVLIYYILVVSPKFSLKSNHYKIFFHQQASFIFSLIWSIGASCDTDGRLAFDAFLRTAVSGRNEEAPMPVSISKWECPFDEKGLVYDYMYELRNRGRWIHWNELIKSSDLEDKRAKIQDIIVPTMDTIRYTFLMDLSITSAKPLLFVGPTGTGKSVYVKDKLMNHLEKEKYFPFYVNFSARTSANQVQNIIMARLDKRRKGVFGPPMGKKCVIFIDDMNMPSLEKYGAQPPIELLRQFFDCGHWYDLKDTSKITLIDIELIAAMGPPGGGRNAVTPRFIRHFNICTINTFSDETMVRIFSSIMAFYLRTHAFSPEYFVLGNQIVSGTMEVYKQSMGNLLPTPAKSHYTFNLRDFSRVIRGCLLIEKDAIESKHTMIRLFVHEVLRVFYDRLINDEDRNWLFLLIKNVIKDHFKESFDTVFHHLRNGNAPVTEEDLRNLMFGDYMNPDLEGDDRVYIEIPDIHHFNEVVDQCLDEYNQTHKRRMNLVVFRYVLEHLSRICRILKQSGGNALLIGLGGSGRQSLTKLATSMAKMQIFQPEISKSYGMNEWREDIKGFLLLIIIWAVVESLSKILEKRLRYLNDHFTYNLYCNICRSLFEKDKLLFSFLLCANLLLAKKEIEYQELMFLLTGGVSLKSAEKNPDPDWLQDKSWEEICRASELPVFHGLREHFCNYIYLWEEIYDSKEPHNMKFPEPMDKTLNELQKIIILRCLRPDKITPAITNYVTDKLGKKFVEPPPFDLTKSYLDSNCTIPLVFVLSPGADPMASLLKFANDKSMSGNKFQAISLGQGQGPVASKMITAAIEEGTWVCLQNCHLAVSWMPTLEKICEDFSPETCNPTFRLWLTSYPSPKFPVTILQNGVKMTNEPPTGLRLNLLQSYLSDPISDTQFFKGCPGKELAWEKLLFGVCFFHALVQERKKFGPLGWNIPYGFNESDLRISVRQLQLFINEYDTIPFEAISYLTGECNYGGRVTDDWDRRLLLTMLADFYNSFIIENPHYKFSPSGNYYAPPKGTYDDYIEFIKKLPFTQEPEIFGLHENVDISKDLQQTKVLFESLLLTQGGAKQTGSSGSTDQVLLEITEDILTQLPNDFDIEAALKNYPVRYEESMNTVLVQEMERFNNLIRTIRNTLRDLKKAIKGLVVMDSALEALSGSLLIGKVPEMWAKRSYPSLKPLGSYITDFLARLKFLEDWFSSGKPSVFWISGFFFTQAFLTGAMQNFARKYTIPIDLLGYEFEVIPFDYSDTPPEDGVYIHGLYLDGARWDRFSGLLAEQYPKLLFDLMPIIWIKPNLKIEIVKIEAYICPLYKTSERKGTLSTTGHSTNFVIAMLLKTDQPTQHWIKRGVALLCQLDN

Gene
DNAH12
Protein
Dynein heavy chain 12, axonemal
Organism
Bos taurus
Length
356 amino acids
Function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Similarity
Belongs to the dynein heavy chain family.
Mass
39.862 kDa
Sequence
MELLLQKGANALGQASDSSSILLEAASGGNPDSVTLLLEYGADANVPKNSGHLPIHVAADRGHLLALKTLVPVTDFAAIKRSGISPIHCAAAGAHPKCLELLIQAGFDVNFMLDQRIRKHYDDHRKSALYFAVSNGDLSSVKLLLSAGAMPNQDPVNCLQIALRMGNYELVSLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTELCFDCPHGDKVHRFSASEGWTSTVIKDTMFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGLWSEIHFILTNPRSLKHLCRLKIRKCMGRLRLRCPVFMSFLPLPSRLKAYVLYKEYDLYEQGIFTGTW
Protein
Dynein heavy chain 12, axonemal: DNAH12