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DIO2

Gene
dio2
Protein
Type II iodothyronine deiodinase
Organism
Petromyzon marinus
Length
288 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
30.946 kDa
Sequence
MPHVNLLVVLLILPGVFSNCLFLALYDAVSFLRRALQASLTHSAKGDAQHPRMLTAQGMLSVWRSYVLDAHKKVRLGGKAPNSSVVALGGHSSSSPSFSCAASSSSSHETPTPRTTAEAAATVTTSTTTTSTTSSTAACRLLDFARAHRPLVVNFGSASUPPFVEQLGEFCDLVRDFAGVADFLVVYIEEAHPSDAWPAPGGLEVPRHLALGDRCVAASQLRGLMPPLGRCPVVADAMDNNANIDYGVSYERLYVIQDGRIRYLGGKGPFFYRVREVKSFLESVKASR

Gene
DIO2
Protein
Type II iodothyronine deiodinase
Organism
Gallus gallus
Length
279 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
31.033 kDa
Sequence
MGLLSADLLITLQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKGNDGSNSSWKSVGGKCGTKCHLLDFANSERPLVVNFGSATUPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDGWAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLEQNFSKRUNPLSTEDLSTDVSL

Gene
DIO2
Protein
Type II iodothyronine deiodinase
Organism
Homo sapiens
Length
273 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
30.552 kDa
Sequence
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG

Gene
DIO2
Protein
Type II iodothyronine deiodinase
Organism
Bos taurus
Length
269 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
30.303 kDa
Sequence
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGQWRRMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTECHLLDFASPERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLFFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFFYNLQEVRRWLEKNFSKRUKLD

Gene
dio2
Protein
Type II iodothyronine deiodinase
Organism
Neoceratodus forsteri
Length
269 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine).
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
30.513 kDa
Sequence
MGLLSVDLLITLQILPWFFSNCLFLALYDSVVLLKHVILLLSCSKSSRGEWRRMLTSEGLRTVWNSFLLDAYKQVKLGGDAPNSKVVRVTSGCCRRRSFSGKGESECHLLDFASSNRPLVVNFGSATUPPFISQLPTFRKLVEEFSDVADFLLVYIDEAHPADGWAAPGVATKSFEVKKHRSQEERCVAAHKLLEHFSLPPQCQVVADCMDNNTNVAYGVSFERVCIVQRQKIAYLGGKGPFFYNLKEVRHWLEQTYRKRUVPTCELIM

Gene
DIO2
Protein
Type II iodothyronine deiodinase
Organism
Sus scrofa
Length
269 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
30.376 kDa
Sequence
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSNPEGSNNHGHGTQEKTVDGAECHLLDFANPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHQNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFYYNLQEVRRWLEKNFSKRUKKT

Gene
dio2
Protein
Type II iodothyronine deiodinase
Organism
Fundulus heteroclitus
Length
266 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
29.678 kDa
Sequence
MGSASEDLLVTLQILPGFFSNCLFLALYDSVVLVKRVVALLSRSRSAGCGEWRRMLTSEGLRSIWNSFLLDAHKQVKLGCEAPNSKVVKVPDGPRWSSTVVPCGSRIQTGGECRLLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAPQMGACSFSFRKHQNLEERIGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVANERVCIVHQRKIAYLGGKGPFFYSLKDVRQWLELSYGRR

Gene
Dio2
Protein
Type II iodothyronine deiodinase
Organism
Mus musculus
Length
266 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
29.929 kDa
Sequence
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRUILD

Gene
Dio2
Protein
Type II iodothyronine deiodinase
Organism
Rattus norvegicus
Length
266 amino acids
Function
Catalyzes the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
29.871 kDa
Sequence
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGNNCASEKTADGAECHLLDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSMSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRUILD

Gene
dio2
Protein
Type II iodothyronine deiodinase
Organism
Lithobates catesbeiana
Length
264 amino acids
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Is responsible for the majority of the intracellular T3 in tissues such as the pituitary, brain and brown fat by mediating local deiodination of T4, and is important in regulating thyroid hormone action in these tissues. Plays a major role in development.
Similarity
Belongs to the iodothyronine deiodinase family.
Mass
29.342 kDa
Sequence
MGLLSVDLLITLQILPGFFSNCLFLALYDSVVLVKHVLLQLNRSKSSHGQWRRMLTPEGLRCVWNSFLLDAYKQVKLGGDAPNSNVIHVTDKNSSSGKPGTPCHLLDFASSERPLVVNFGSATUPPFISQLPAFSKMVEEFSAVADFLLVYIDEAHPSDGWAAPGISSYEVKKHRNQEDRCAAANKLLEQYSLPPQCQVVADCMDNNTNAAYGVSFERVCIVQRQKIVYLGGKGPFFYNLQEVRQWLELTFGKKAESGQTGTEK