Protein
Viral dihydrofolate reductase
Organism
Saimiriine herpesvirus 2 (strain 488)
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Sequence
MVLLLNCIVAVDQNMGIGKKGHLPWPLLINDFKYFQRMTTSSVKNKQNLVIMGKNTWFSIPEKNRPLKDRINLVLSKKLKEIPHGAHFLARSLNDALKLIEQPELVNKVDRVWIIGGSSVYKDAMNYSSHLKLFVTRIMQSFETDTFFPEIDLKNYKLLIEYPGVPSNTQEEKGIKYKFEVYEKIVNTFLFKSHAGLTCSVKPKEASYDFELS