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DHFR

Gene
DHFR
Protein
Viral dihydrofolate reductase
Organism
Saimiriine herpesvirus 2 (strain 488)
Length
213 amino acids
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
24.577 kDa
Sequence
MVLLLNCIVAVDQNMGIGKKGHLPWPLLINDFKYFQRMTTSSVKNKQNLVIMGKNTWFSIPEKNRPLKDRINLVLSKKLKEIPHGAHFLARSLNDALKLIEQPELVNKVDRVWIIGGSSVYKDAMNYSSHLKLFVTRIMQSFETDTFFPEIDLKNYKLLIEYPGVPSNTQEEKGIKYKFEVYEKIVNTFLFKSHAGLTCSVKPKEASYDFELS

Gene
DHFR
Protein
Dihydrofolate reductase
Organism
Mesocricetus auratus
Length
187 amino acids
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
21.66 kDa
Sequence
MVRPLNCIVAVSQNMGIGKNGDFPWPMLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELADKVDMVWIVGGSSVYKEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKG

Gene
Dhfr
Protein
Dihydrofolate reductase
Organism
Mus musculus
Length
187 amino acids
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (PubMed:25980602). Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (PubMed:25980602). Binds its own mRNA.
Similarity
Belongs to the dihydrofolate reductase family.
Mass
21.606 kDa
Sequence
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD

Gene
Dhfr
Protein
Dihydrofolate reductase
Organism
Rattus norvegicus
Length
187 amino acids
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
21.638 kDa
Sequence
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD

Gene
DHFR
Protein
Viral dihydrofolate reductase
Organism
Saimiriine herpesvirus 2 (strain 11)
Length
187 amino acids
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
21.719 kDa
Sequence
MVQALNCIVAVAQNMGIGKQGNLPWPRLMNDFKHFQRMTTTSSVPDKQNLVIMGKKTWFSIPEKNRPLKGRINVVLSKELKELPHRAHFLAKSLDDALKLTEQPELANKVDMVWIIGGSSVYKEAMSYPCDLKLFVTRIMQDFECDTFFPEFDLEKYKLLIEYPSVLSNVQEEKSIKYKFEVYEKNH

Gene
DHFR
Protein
Dihydrofolate reductase
Organism
Sus scrofa
Length
186 amino acids
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
21.455 kDa
Sequence
VRPLNCIVAVSQNMGIGKNGDLPWPPLRNEYKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLTEQPELKDKVDMVWIVGGSSVYKEAMNKPGHIRLFVTRIMKEFESDTFFPEIDLEKYKLLSECSGVPSDVQEEKGIKYKFEVYEKNN

Gene
DHFR
Protein
Dihydrofolate reductase
Organism
Aedes albopictus
Length
186 amino acids
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
21.447 kDa
Sequence
MKKFSLIVAVCANGGIGIKGDLPWRLRQELKYFSRMTKKIQDSGKRNAIIMGRKTYFGVPESKRPLPERLNIILTRDPSANAYPSEVMVCTSMQEALKKLDEAPLVNEIENVWIVGGNAVYKEAMQSDRCHRIYLTEIKETFECDAFFPEITSDFQLVKNDDDVPEDIQEENGIQYQYRIYEKVPK

Gene
DHFR
Protein
Viral dihydrofolate reductase
Organism
Saimiriine herpesvirus 2 (strain 484-77)
Length
186 amino acids
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
21.674 kDa
Sequence
MVLLLNCIVAVDQNMGIGKNGYLPWPLLTNDFKYFQRMTTSSVKNKQNLVIMGKNTWFSIPEKNRPLKDRINLVLSKKLKEIPHGAHFLARSLNDALKLIEQPEFVNKVDMVWIIGGSSVYKDAMNYSSHLKLFVTRIMQSFETDTFFPEIDLKKYKPLIEYPGVPSNTQEEKGIRYKFEVYEKNY

Gene
dhfR
Protein
Dihydrofolate reductase
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Length
168 amino acids
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
Similarity
Belongs to the dihydrofolate reductase family.
Mass
19.703 kDa
Sequence
MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV