DHC10

Dynein-1-beta heavy chain, flagellar inner arm I1 complex

4513 amino acids

Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis.

510.667 kDa

MEPGDEGKGHQLTADATCIAWVRSKLQLLKPESLGDSDGAEWLSSVWHNDVHTPVVSTFLMSVKATRMFAALDGGHEGGSSPKLVLALEVPKQFEQMVYFVRDPSKFVTRENVGSVIFFGVMRGGDPLHSLLNIMHGLYVPVVVANTTWPETVKSDFTAQMHKFMANLTETVYEVKGKTILYIPQEDLRDPKAAAKQKDLVQRLESTIIHWTRQVKELLNQQDSVDASEQAGPLAEIEFWRERSVDLSGIRAQLDDGAVSSIVSVLEYAKSSYLAPFLSLRNLIHREAVAAEDNLKFLLCLEEPCQQLASAHPQTIPSLLPPILNCIRMVWNLSRFYNTPERLSVLLRKLSNEIINRCCSVISLPDVWSGDVDNVMVALRQSMEAGERWKELYKRTAAAVAVRSPKPWDFDISSIFAHIDAFLQRCNDLLEVCEAQLQFAPRTPLPVFGGTYGPEVKKSILDIQESFQGLVQGLQALKYDILDVKATRWHDDFNGFKGGVKDLEVMMANVIQRAFDTQPCLAARGELLEGFQTMAKRDYIRRFVEKKTVEFFALFNAEINTVKKLFDAVKRSQPKSPILPRYAGLAKYAMNLMRRLEQSHKVVDSVRYTLPQVSEAADVMQQYELAHQAIEQYISNTHNDWFSTIESSIAKELQACLLTQDKASGGLLSMNFHKDLLSMGQEVHFWERMRLAVPLVAMEINAQREKYRVLRDNILMVVRDYNKILTALDKEERKLFHDRIRYLDRRIMPGVTKLQWTADKHALEFYYREARKFCRDADMAVGDYKTANSRLDAICRSISELVLVDVEKKKIYQHAEFANLQESHHAKIKDRLVSAVDEIRDIMASIHRVFEQDSEEVQREWVRFTQKVDRKLEDALRHVIKKSLQELSRLLNGDNKTEVMPIFHVTMVLERTNRVELRPTIQALFDTINSVARNLILVLQSVPRVALQLTDKQRRDMEDAGLPLPKPLPTLYETISADEDAVLRTIMQITSGITSIIDKVQAFLTYWEKKYRQVWEADRDAYIRRYEKAQKPLSSFEADISRYLQCIDEIRGEDGATNMRFLRIDCGPLKLTLVGHCEAWVSKFTGLLGQLAATELRTLHTYFRENKDSLMLAPSTLEQLAELVGLHRRLADERRRTEARFEPLRDKYKLLERYEVGAKEEEAALLEGLEPAWTQFQALLDETAGKLERYKDNFREKVKSLLDTFLKDVAQLCEDFSRDAPYSSEVPTPDALDFIQASKQADEDTRKRAAEIKNGMDIFNIPQPQYKDLAAMEKDLDFLDRIWGLKDEWEQLYYGWKDGSFTDIKVEEMEEAAVRIGKNVAKLGRDIRQWTVWSSLKDTLDAFKRTMPLITDLRNPAMRPRHWQNLQDHIGVRFDPHSRDFTLDSLVALRLDQHVEFVAELSVNATKELAIENNIKAIAATWSALGLDMAEYKSTFKLRSTEEIFTSLEENIVTLSTMKASKYFIVFEKDIAYWEKTLSHISETIEIILQVQRNWMYLENIFIGSEDIRKQLPQESQMFDAVHNNFMRLMKQLYSTANCLKACTAQGLLESFQDMNNKLERIQKSLDNYLENKRQQFPRFYFLSSDDLLEILGQAKDPLNVQPHLKKCFEGIKKLDMHLPGEDRKQTISVGITSPDGEYLPFANPVITEGRPEEWLNRVEDAMFLTTKKHLYKVLEESKAQKKEKWVKENQGQMIITAGQIVWTHECEKALADADSARKNLKLLKKKWISYLNKLTAVTRSKLNKIERNKVVALITIEVHARDVIEKLGKSNCSSTNDFEWVSQLRFYWDREKNDCIVKQVLSVFYYGYEYQGNNGRLVITPLTDRCYMTLGAAMFTRRGGNPLGPAGTGKTETVKDFGKALARYVIVFNCSDGVDYKMTGKMFSGLAQTGAWACLDEFNRIEVEVLSVVATQIAAVMQAIKESKKRFLFLGQEIRLNPSCGIFVTMNPGYAGRSELPDNLKAMLRPVSMMVPDFTLIAEIMMFSEGFSSAKVLAKKMIAIMELSQQQLSKQDHYDYGLRSFVIPIARAAGSLKRLDPEGSEEVILYRTMLDLIKPKLVYLDLPLFMALLSDLFPGVELPPADGGSLRRAIEAELRESNLQIVPEFVTKIIQVFDCKVARHGNMIVGRTGSGKSEAWKCLQRALGRLRKEEPDDDRFQKVHVHTINPLALSNDELYGCFEAATHEWQDGVLARIMRTVCKDETHEQKWILFDGPVDTLWIESMNTTLDDNKLLTLLSGERIAMTPAVSLLFEVEDLSQASPATVSRAGMIYLNVEDLGWRPFITSWLAAKQAAPGADAAIIDQVSKLVDKYMEAALEHKRLHCRELVPTDRLSCVRAFTRLWDALAVPENGVGTMPVDESAGPPGSKAAAAAAAAAAAAAPPEETSGGTGGNLVEMWFLFCLIWGIGGPLDEEGRKKFDAFMREMDTRYPSSDTVFEYFVEPKAKSWLAWETKLTGAFKPAMDQPFFKILVPTVDTVRNRFVGSALVRVSQHTLIVGNVGVGKTMIVGSLLEGLPGDRMSSMTINFSAQTSSNSLQDTIEGKLEKRTKGVFAPAGGKRLVCFIDDLNMPQKSKFGFIPPLELLKLWVDNGFWYDRAKCEVKHIKDMQLLAAMAPPGGGRNAFSQRVQACFATLNVTAPNDNQLKRIFGTILNAKLADFDDEVKPLSEPITMATIGIYRAVSKELLPTPSKSHYLFNTRDLAKIIQGMMQATKAFYNSKEEVLQLWCHECMRIIADRMWDHADKEWLVRQLDEKLGTTFSTSFGTLFEAYNETVPPFVTFMRQNVDVPVYEAVRDMVALKDLLTERLEDYALEPGHSAMDLVLFRDALSHVCRIHRILGQPRGNALLVGVGGSGRKSLARLAAFVAELKCFTIEITKNYRQTEFREDLKGLYRQAGVANKPTVFLFDETQIVYETFLEDVNNILTSGEVPNLFPKDELGSVLDELRPAAKAAGAGETADALYGFLLERVRTNLHVVLCLSPVGEAFRERCRMFPGLVNCTTIDWFTEWPADALFEVAQKQLMDVDLGSTEVKTAVCKVFVTAHQSVENTSAKMFAALKRRNYVTPTNYLETVRGYKGLLAEKRTELGEKAAKLQGGLHKLDETSVQVAAMKKVAEEKKVVVAQAKADCEELLVEIVQDKRVADEQEKQVNAEAQKIGKEAEEANIIAAQVQQELDKALPALREAEAALDVLTKKDMSELKAYAKPPEKVEMTLNAVLTVLRRPPNWDEAKKRLSDANFMQSLKEFDKDKLDDSLLKKIGKFTANPDFTYEKINTVSAAASGMCKWVHAMETYGYVAKDVAPKRAKLKSAQDTLARKQAALALAQEQLAVVLAKVQALKDKYDTSIARKQALEEELADLEGKLERAEKLVTGLAGERVRWEASISEYNIALGCLPGDVVVAAAFMSYAGPFPSEYRDELVKHTWLPQVKALNIPASEHFDFALFLANPAMVRDWNIQGLPSDSFSTENGVMVTRGRRWPLMIDPQGQANKWIKNMEGRGGRLKVLNLQMSDMARQIENAIQFGQPVLMQDILQEIDPILEPVLAKSFIKRGNQTLIKLGDKEVDYNFDFRLYLTTKLANPLYTPEISTKVMIVNFAVKEQGLEAQLLATVVKNERPDLDKQKNDLVVKVAAGKRTQAELEDTILHLLSTATGSLLDNVTLINTLDQSKTTWEEVNASLAVAEETQKKIEAASQLYRPCSVRASVLYFVLNDLSTIDPMYQFSLDAYNDLFLLSIKNSPKNDNLAERIKSLNDFHTYAVYKYTSRGLFERHKLLLSLQMCVRILQTANQVNTEEWQFFLRGGTVLDRSSQPNNPSQEWISEEAWDNITELDALPNFKGVVSSFESNLGEWEAWYRKGDPEASELPAEWESKCNELQRLILVRCLRPDRVIFAATTYVSNALGRKYVEPPVLDLAETLKDSTALSPLIFVLSAGVDPTDNLRKLATEKGMTSRFFTVALGQGQAPTATRLIEDGLREGNWVFLANCHLMTSWLPTLDKIIEGFETKQPHENFRLWLSSNPSPSFPIAILQRGIKMTTEPPKGLRANLLRLYNSVSDASYAQCKTQIKYQKLLFALTYFHSVLLERRKFRTLGFNIPYDFNDTDFSVSDDLLKSYLDSYEQTPWDALKYLIAEANYGGRVTDELDRRVLASYLNKFYCEDALAVPGYLLSPLSTYYVPENGPLQSFKDYILTLPAGDRPEAFGQHPNAEISYLIEDSKVLLDSLLSLQPRTEGAAGGAGTRREDVVMAIATDLLDQVPQPFNLEEVMKAKADDPSALHVVLFQEVERYNALLVAVRRSCVELQRGIKGLVVMSADLDLIFESLYAAKVPAAWLKTYPSLKPLGPWTRDLLQRIEQLATWVEETYPRVYWLSGFTYPTGFLTAVLQTTARKASVPIDTLSFEFSIINLDEREINAPPKEGVYIKGLFLEGAGWDFENGCLCEPNPMELIVPMPILLFRPVENKKRTAKGIYTCPLYLYPLRTGTRERPSFMINVDLRSGSADPDHWIMRGTALLLSLAT