DENND6A

Protein DENND6A

608 amino acids

Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.

Belongs to the DENND6 family.

69.575 kDa

MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQSSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMGVVMKVRIPTCHDKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQKGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKLLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQGILLKTGMT

Dennd6a

Protein DENND6A

605 amino acids

Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity).

Belongs to the DENND6 family.

68.967 kDa

MALPGPAVFGPGSRGSLDEAGAEGREAAALAAAGVALEDEEEDDGRRGLLRWDGFSAWLHCVCVVGFDLELGQAVEVIYPQHSKLTDKEKTNICYLSFPDSNSGCLGDTQFCFRFRQSSGRRVSLHCLLDEFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLPYIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMGLVMKVRIPTCHDKPGTTQMVQLTQQADTHTSIILPTVHEVDLFRCFCPVFLHSQMLWELVLLGEPLVVMAPSPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDLKPAGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQKGIQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPEEFMKTLEKTGPQLTSGIKGDWIGLYRQFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLLLWIQKHTEVETVDLVLKLKNKLLQAGRESLPVKPDTVEKLRTHIDAIILALPDDLQGILLKTGMT

DENND6A

Protein DENND6A

584 amino acids

Guanine nucleotide exchange factor (GEF) for RAB14.

Belongs to the DENND6 family.

67.051 kDa

MALWERGAGGAAEAGEDATEEPERGLPLLPWDRFSAWLHCVCVVGFDLELGQAVEVIYPPHSKLTDKEKTNICYLSFPDSNSGCLGDTQFCFRFRRSSGRKASLCCFLDHLDRDLPVYLKKDPAYYYGYVYFRQVRDKSLKRGYFQKSLVLISKLPYIHLFRTVLKQIAPEYFEKSEAFLEAVCSDVDRWPPPVPGEVLHLPIMGVVMKLRIPTYRDKPGTTPVVQNMHQADAQISMTLPTVHEVDLFRCFCPVFFHIQMLWELVLLGEPLVVMAPSPAESSETVLALVSCISPLKYCSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDMKLPGDVPKQVKVKKLKNLKTLDSKPGVYTSYKPYLDKDEEIVKQLQKGVQQKRPTEAQSAILRRYFLELTESFIIPLERYVASLMPLQKCISPWKSPPQLRHFSQDDFMKTLEKAGPQLTSGLKGDWIGLYRHFLKSPNFDGWFRSRQKEMTQNLEALHLEALCNENLVFWSQKHTEVETVDLVLKLKNKLLQADREHLPVKTDTLKKLQTHIRDIILALPDDLQDILLKTGTA