ddx42

Probable ATP-dependent RNA helicase ddx42

986 amino acids

probable ATP-dependent RNA helicase which may bind to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures.

Belongs to the DEAD box helicase family. DDX42 subfamily.

110.817 kDa

MSKRVSAFGAEGDDEPQEKPMKPFISFSSNINNNNNSNNNNNNNNNNNNNNNNNNNKNNIGTGINLNIKNNNNINNNNNKSGFPVKKSRFNGEDDDDDYFFSNVPPKSSMTTLNKSPPNFENASSNNNNNNNNNNQESDSKNQNEDEDDEIDPLDAFMENVNAQAAIDNSKSIEKGQQQQQSLKSKRDDIDNEDDEEIFYKLRQKQLANKSSKQQQDDDVDYSSLDDDDGYFDDEESLKNGQSKGKRIIEPLPPIDHSKEEYIEFNKIFYEEHPDIANLTEEQVFEIRKNLDIRMTGTDLINPVTSFGHYGFDDILLQAIAKQSIETPTPIQKQAIPIALSGRDLIAIAKTGSGKTATFIWPSISHIMDQPYLEKGDGPIALFLAPTRELAHQIYLETLKYSKYFKLKTTVLYGGVSKQQQCKELKAGCEIIVATPGRLIDMIKLKATKLNRVSYLVLDEADKMFDFGFGPQVLSIVNHVRPDRQTLLFSATFKPNVEEFARTILSDPIKISIGMIGSANSDITQIVQVLKSDSDKWNWLTNQLALLLSQGSVLIFVSTKVAVEQLSSNLTKFGFQTCTLHGDKNQIERSQTIQTFKEGKINILIATDVAARGLDIPLIKNVVNYDTSRDIESHTHRIGRTGRAGNTGVAYTLITPKDIHFSVDLIKNLESASQFVPPELIDVAMNNPHFKRERGGGGGGSNRGRGRGGGGVGYRRNSRGGGVAFNSNRDSSRSDSQNKFIPAQSVEGGRLFNPNNTDNSEINNENEKSINNENKFSNNNSGSSNDRNSINYRNNSFNNNSNNTNNSGNSNFNNSNSNNGYSNNNYNNNYKNNSNYNNSNNNNNSYYNNNNSNNNNNSNYNNSSNNNNNNNNNYRNGNNNNNYNNNNYYNNNNSNNNSSNNNNSNNNSSNNNFNNNFNNNNNNNDNSNFNRALPFNDFNNNNNNSNNNNFNYNNNFNNSYNANNSNHYKNNNNSNNFNQRSQYNRR

ddx42

ATP-dependent RNA helicase DDX42

947 amino acids

ATP-dependent RNA helicase. Binds to RNA. May be involved in the survival of cells (By similarity).

Belongs to the DEAD box helicase family. DDX42 subfamily.

104.079 kDa

MNWNKGGSGNKRGFGFGGFAISTGKKEEPKLPQVSHSAFQSASSKYGSTSNQLPSFYKIGSKRANFDEENSYFDDEEEDSSNVDLPYIPAENSPTRQQLRSKTDSDSEEDPLEAFMAEVEDQAAKDMRKLEERDKEKANARGIRDDIEEEDDQEAYFRYMAENPTAGLVPEEEEDNLEYDSDGNPIAPTTKRIIDPLPPIDHTEIEYPPFEKNFYEEHEAITSQTPQQITELRHKLNLRVSGAAPPRLCSSFAHFGFDEQLLHQIRKSEYTQPTPIQCQGIPVALSGRDMIGIAKTGSGKTAAFIWPILVHIMDQKELQPADGPIAVIVCPTRELCQQIHSECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVTYLVFDEADRMFDMGFEYQVRSIANHVRPDRQTLLFSATFRKKIEKLARDILVDPIRVVQGDIGEANEDITQVVEILPSGPEKWTWLTRRLVEFTSTGSVLVFVTKKANAEELAANLRQDDHPLGLLHGDMDQSERNKVISDFKKKSIPVLVATDVAARGLDIPSIKTVVNYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTSKESNFAGDLVRNLEGANQYVSKELLDLAMQNSWFRKSRFKAGKGKKLNIGGGGLGYRERPGLGAESSEHGTGGNVMSNYEAFKPSGGAMGDRLSAMKSAFQSQYKNHFVAASASTQKTGTSSINSGAWTSAGSLSSVPSAHPPSGKLPAEAAPPPVHTAMLGFTSSGTLSSIPTGYPANISSASYPAATLFGARDGASAGTESGGRERHSDSKGRHGDSHRPSDREGYRHGDGHRHSSSSRHGERNGGEGRRESSRDGRRDSSRDGESRRDGSRDGGEGRRESSRDGEGRRESSRDGDGRRESSGDGRREVVGDDGDSRKEGTREAKTDTFAIPVPPKRKKSRWDS

DDX42

ATP-dependent RNA helicase DDX42

944 amino acids

ATP-dependent RNA helicase. Binds to RNA. May be involved in the survival of cells (By similarity).

Belongs to the DEAD box helicase family. DDX42 subfamily.

103.054 kDa

MNWNKGGPGTKRGFGFGGFAITPGKKEEPKLSQQSHSAFGTAGSSAAFAKSGPPQLPSFYKIGSKRANFDEENAYFEDEEEDNSNVDLPYIPAENSPTRQQFNSKSADSDSDDDPLEAFMAEVEDQAARDMKRLEDKDKEKKNAKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKKIIDPLPPIDHSEIEYPPFEKNFYDEHEEITSLTPQQVVELRHKLNLRVSGAAPPRPGSSFARFGFDEQLMHQIRKSEYTQPTPIQCQGVPVAMSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHSECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVTYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEIFPSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEDHNLGLLHGDMDQSERNKVISEFKKKGIPILVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNPWFRKSRFKGGKGKKPNIGGGGLGYRERPGLGSESSDRGNNNSVMSNYEAYKPSSGAMGDRLTAMKAAFQSQYKSHFVAASLNNQKTGSSAAGASGWTSAGSLNSVPTSSAQQNAANPDSPIAATAAAKGVPGFTSTGTLSSVPTFPSVGVQGYSNNSSANASAGNREGVGSAGSAPRGGSSGGGGGGIVRERYSDNRNSRHNEVPRRGEGGGRYNDVQHHGEGGGRYSDAYRHGEGRHGDSHRHAEGRHFTDTGGGNRNNVDGRNISEGRSNESRNGENRKDANSRDNKTDGFAVPEPPKRKKSRWDS

DDX42

ATP-dependent RNA helicase DDX42

942 amino acids

ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm (By similarity).

Belongs to the DEAD box helicase family. DDX42 subfamily.

103.498 kDa

MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPIDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQETYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAEGKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPITSATKGIPGFGNIGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEACNRESKMEPKMEPKMEPKVDSNKMDKVDSKTDKTADGFAVPEPPKRKKSRWDS

DDX42

ATP-dependent RNA helicase DDX42

938 amino acids

ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.

Belongs to the DEAD box helicase family. DDX42 subfamily.

102.975 kDa

MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEAFNRESKMEPKMEPKVDSSKMDKVDSKTDKTADGFAVPEPPKRKKSRWDS

Ddx42

ATP-dependent RNA helicase DDX42

929 amino acids

ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm (By similarity).

Belongs to the DEAD box helicase family. DDX42 subfamily.

101.965 kDa

MNWNKGGPGTKRGFGFGGFAISAGKKEEAKLPQQSHSAFGAASSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPADSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELASNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENSDRGNNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGTSSAGASGWTSAGSLNSVPTNSAQQGHNSPDNPMTSSTKNIPGFNNSGNISSAPVTYPSIGAQGVNNTASGNNSREGIGGGNGKRERYTENRGGSRHSHGDGGNRHGDGGRHGDGYRYPESGSRHTDGHRHGETRHGGSAGRHGESRGANDGRNGESRKEGFNRENKMDPKVDSSRMDKVDSKTDKTPDGFAVPEPPKRKKSRWDS