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DDB_G0279593

Gene
DDB_G0279593
Protein
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Organism
Dictyostelium discoideum
Length
757 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation.
Mass
87.953 kDa
Sequence
MFQSNQYDEYNKTNKSDEENESNENENENENENENRSEDGDQDSEDSFIYEEDDEEEEDTPKLSFGAKFLAKHGHIEGQGLGKEKDGRIDLIEVDRFQSTKGLGFAENDLPEFYRVTKHILEDEDVDFPSKQRFEWISCNSEGYNFWEGFPVDHTLVKFVANDSITDKPRRGHCSVELLMELDQHKNALDTLDPNRFYVARKKSNPYESIKGSIFINRAAVKMANIDKLADLLTPIIPVPGKPRDFIYFGDVCAGPGGFTEYVYWKKTRGGKIKGEEGLDLDDVVKGFGFTIKGQCDWNVEKFSKQIPIHNFVKEYGLDDTGNILKSENIRDFSSKVFYNTNGFGLQLFLADGGINTDGKESLQELMLQQLILCQILTMFETIGRGGNFVCKIFDTFTPFTIGLLYLVYQHFQSFSIVKPFTSRPLNSERYIICKNFLSYRPMNIIDFLHYINSLLNNNQTILELIEINSMDPNFLRYILESNELICLRQIKAFSLFKKYVEDIELPPIDQKEIRAKCLEEWGLPKETKYDIENYQKHKNRQKHHHNNHSNNNNNNNNSNNNNNNNNQHQHQHHQHQHHQNQHQNQYQHQNQHKKYNNNINNNSNNSSPNSSPNLTSSPNLNSPPNINNGNNHQNNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNKNRRFISTKLVKNNSQFQQKPPPPHRHMSPLQIQQQFLLQQQKEQQLLQQPQKDQLHQLHQQQSQSALPDFSAANFMEALLKRKNDSQQ