DCST1

Gene

Dcst1

Protein

E3 ubiquitin-protein ligase DCST1

Organism

Mus musculus

Length

732 amino acids

Function

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.

Mass

84.332 kDa

Sequence

MAFLSSTLHSLGIFEKISRIKEVLKNRLLDLTKRRDQAREQQRKRPHTIIQGLLLWSLPVSWIRFLWRQPGEFPVTAFLLGAGTGGLLAIGLFQLLVNPMNIYEEQKVVALYCLASLGAIGWGTSPHIRCASLLLVPKMLGKEGRLFVMGYALAAIYSGPAANLRSNINEVIASLGCTVELQINNTRSAWRVSTAPLRAVFKGMVGSKDSLNKEIQNVSTSFEEMDEQVKSDAGYSSEDWDKNRESTEMFGTSRVRPYLSTQMVYELRTRLRCIHVVNKAILSCYRWFDKKHKNCMRRIHLPLFNNMICVPMKFKFLCNIAKVIEIWCYKRIPVEGNFGQTYDSVNQSIHGLSGEFSANINLKEEKQSSMVGLNTTNWEHMGTEVRDYVRQQETYLQWAMGLLHVLLSCTFLLVFHSAFSYMDHYNWDIRFDNIYISTYFCQIDARRKKLGKQSLLPLRKAERKTVIFPFKATIQAWEMRYVIRELLETLPIVLLLLVLCAIDWALYSVFDTIRQHSFVQYSFRSSHKLEIKVEGDSILAKLLRKTIGALNTSSSTDVETNNMPCLPQPISLNARDYFKASLPTLLLVCLCLAQAFGYRLRRVIAAFYFPKREKKRALFFYNEFLKKRSAFTKLRRAAIVRRANQQKAPPHYLVEALYRRCPLLHRFMRQRCVVCQAMETPDSYVCPTPDCKALYCRSCWDDMQRLCPVCTPREELSSSAHSDSNDDAVYGD

Protein

E3 ubiquitin-protein ligase DCST1: Dcst1

Gene

Dcst1

Protein

E3 ubiquitin-protein ligase DCST1

Organism

Mus musculus

Length

732 amino acids

Function

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.

Mass

84.332 kDa

Sequence

Protein

E3 ubiquitin-protein ligase DCST1: Dcst1

Gene

DCST1

Protein

E3 ubiquitin-protein ligase DCST1

Organism

Homo sapiens

Length

706 amino acids

Function

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.

Mass

80.712 kDa

Sequence

MDIKHHQNGTRGQRRKQPHTTVQRLLTWGLPVSCSWFLWRQPGEFPVTALLLGAGAGGLLAIGLFQLLVNPMNIYEEQKIMFLYSLVGLGAMGWGTSPHIRCASLLLVPKMLGKEGRLFVLGYALAAIYVGPVANLRHNLNNVIASLGCTVELQINNTRAAWRISTAPLRAMFKDLLSSKELLRAETRNISATFEDLDAQVNSETGYTPEDTMDSGETAQGREARQAPASRLHLSTQKMYELKTKLRCSYVVNQAILSCRRWFDRKHEQCMKHIWVPLLTHLLCLPMKFKFFCGIAKVMEVWCRNRIPVEGNFGQTYDSLNQSIRGLDGEFSANIDFKEEKQAGVLGLNTSWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLHASFSYMDSYNHDIRFDNIYISTYFCQIDDRRKKLGKRTLLPLRKAEEKTVIFPCKPTIQASEMSNVVRELLETLPILLLLVVLCGLDWALYSIFDTIRHHSFLQYSFRSSHKLEVKVGGDSMLARLLRKTIGALNTSSETVMESNNMPCLPQPVGLDARAYWRAAVPIGLLVCLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLKKRAAFTKLRRAAILRRERQQKAPRHPLADILHRGCPLLRRWLCRRCVVCQAPETPESYVCRTLDCEAVYCWSCWDDMRQRCPVCTPREELSSSAFSDSNDDTAYAG

Protein

E3 ubiquitin-protein ligase DCST1: DCST1

Gene

DCST1

Protein

E3 ubiquitin-protein ligase DCST1

Organism

Homo sapiens

Length

706 amino acids

Function

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.

Mass

80.712 kDa

Sequence

Protein

E3 ubiquitin-protein ligase DCST1: DCST1