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DCP1

Gene
DCP1
Protein
mRNA-decapping enzyme subunit 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
231 amino acids
Function
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. DCP1 is activated by the DEAD-box helicase DHH1 and destabilizes the eIF-4F cap-binding complex from the mRNA.
Similarity
Belongs to the DCP1 family.
Mass
26.266 kDa
Sequence
MTGAATAAENSATQLEFYRKALNFNVIGRYDPKIKQLLFHTPHASLYKWDFKKDEWNKLEYQGVLAIYLRDVSQNTNLLPVSPQEVDIFDSQNGSNNIQVNNGSDNSNRNSSGNGNSYKSNDSLTYNCGKTLSGKDIYNYGLIILNRINPDNFSMGIVPNSVVNKRKVFNAEEDTLNPLECMGVEVKDELVIIKNLKHEVYGIWIHTVSDRQNIYELIKYLLENEPKDSFA

Gene
DCP1
Protein
mRNA-decapping enzyme subunit 1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
193 amino acids
Function
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).
Similarity
Belongs to the DCP1 family.
Mass
22.329 kDa
Sequence
MTTARDNSATTLELYRKTLNFNVIGRYDPKIKQLLFHTPHATVYKWEAGENKWNKLEYQGVLAIYLRDVREQAELPVPHQEASAGAEGRCGEVLSGRDIYNYALIVLNRINPENFSIAIAPNSVVNKRRLFSPEENVQQPLEPMDVEVKDELVIIKNLRKEVYGIWIHTPTDRQNIYDLLKYLLENEPKDSFA

Gene
dcp1
Protein
mRNA-decapping enzyme subunit 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
127 amino acids
Function
Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.
Similarity
Belongs to the DCP1 family.
Mass
14.983 kDa
Sequence
MEDENILRNAVNLQVLKFHYPEIESIIDIASHVAVYQFDVGSQKWLKTSIEGTFFLVKDQRARVGYVILNRNSPENLYLFINHPSNVHLVDRYLIHRTENQHVVGLWMFDPNDMSRIFNIVKESLLR