DCLRE1A

DNA cross-link repair 1A protein

1040 amino acids

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.

116.4 kDa

MLEDISEEDIWEYKSKRKPKRVDPNNGSKNILKSVEKATDGKYQSKRSRNRKRAAEAKEVKDHEVPLGNAGCQTSVASSQNSSCGDGIQQTQDKETTPGKLCRTQKSQHVSPKIRPVYDGYCPNCQMPFSSLIGQTPRWHVFECLDSPPRSETECPDGLLCTSTIPFHYKRYTHFLLAQSRAGDHPFSSPSPASGGSFSETKSGVLCSLEERWSSYQNQTDNSVSNDPLLMTQYFKKSPSLTEASEKISTHIQTSQQALQFTDFVENDKLVGVALRLANNSEHINLPLPENDFSDCEISYSPLQSDEDTHDIDEKPDDSQEQLFFTESSKDGSLEEDDDSCGFFKKRHGPLLKDQDESCPKVNSFLTRDKYDEGLYRFNSLNDLSQPISQNNESTLPYDLACTGGDFVLFPPALAGKLAASVHQATKAKPDEPEFHSAQSNKQKQVIEESSVYNQVSLPLVKSLMLKPFESQVEGYLSSQPTQNTIRKLSSENLNAKNNTNSACFCRKALEGVPVGKATILNTENLSSTPAPKYLKILPSGLKYNARHPSTKVMKQMDIGVYFGLPPKRKEEKLLGESALEGINLNPVPSPNQKRSSQCKRKAEKSLSDLEFDASTLHESQLSVELSSERSQRQKKRCRKSNSLQEGACQKRSDHLINTESEAVNLSKVKVFTKSAHGGLQRGNKKIPESSNVGGSRKKTCPFYKKIPGTGFTVDAFQYGVVEGCTAYFLTHFHSDHYAGLSKHFTFPVYCSEITGNLLKNKLHVQEQYIHPLPLDTECIVNGVKVVLLDANHCPGAVMILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTTYCSPEYTFPSQQEVIRFAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIPEINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKCGGKYNQILAFRPTGWTHSNKFTRIADVIPQTKGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGTWKSRSTMEKYFREWKLEAGY

Dclre1a

DNA cross-link repair 1A protein

1026 amino acids

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.

113.567 kDa

MLEDTWEEEIWEYKSKRKPKPVHPNNCSENISESVEKSTDGKHQSKGNEKRTSENPGKTKDHKVCLAETDSQISAGSSQSSSCRDESQQSQNKETTPKKQHRTRRGKQVTPKVRPVYDGYCPSCQMPFSSLLGQTPQWHVFECLDSPPISDTECPEGLLCTSTIPSHYKKYTHILLAQSRDSKEPLGSPSDALAGLFAAAAPGSPCNLEERRSMTLKTENLRKVSDHSLLMMQYLETSQPSAEINRKNVSSPCSQTSPVPQCAEFVKRDQLVGGGSPLAEVALNSQSKSGSMGLPLPENDTDSCEISYSPLHSDEETYDIDQELDDSQQELFFTQSSKDSSLEEDGSAIFENLHGPSPKEAEGIRPTAKSLVAQARCSAPSEGSTLSDSFLLLSYTSNRLSQEDLPHTDAAFHLLSPALAVGGAASNYQTSKAKLDEPEKFLSLASSHQQQKIETSAVGNQTSLPLLTRARSKPLEKEGGKCLPLHPTQSQTRGSPRKGLGAPGANCACRNAQKRSSMPLDKPLGTSPSSPKCSPSQPSKKVMKQMDIGVFFGLPPKRQETSLRESASEGPNVSPVVSPNQKRPRLCKRKAQSSLSDLEFDAKNLNESQHSVGLSGEKRQHRRKRHKTSNSPREGPCQRRSGHLMNNPELGPVSLSKAFVRRTRGRTQRGNMNISESSGAGEVRRTCPFYKRIPGTGFTVDAFQYGEIEGCTAYFLTHFHSDHYAGLSKDFTRPVYCSEITGNLLKKKLRVQEQYIRQLPMDTECVVDSVKVVLLDANHCPGATMILFQLPNGAVILHTGDFRADPSMERSRLAGRKVHTLFLDTTYCSPEYTFPSQQEVIQFAINTAFEAVTLNPRALVVCGTYCIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIPEVSSLITTDMCDSLVHLLPMMQINFKGLQSHLKKCGGKYDQILAFRPTGWTHSNNITSTADIIPQTRGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGSFRSRNTMEKYFKEWRLEAGY

DCLRE1A

DNA cross-link repair 1A protein

972 amino acids

May be required for DNA interstrand cross-link repair.

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.

108.328 kDa

MSEDVLLEEDIWEYKSIRKRKPQSNPDSTSVSMQTVTKGKCRPKRKGSGNRKKSVEKNSTPQKSEQRLRPSEDLDPCKDDSSVYAQESVSSLTEQGSPSTRPVCDGYCPSCQMPFSLLVVQTPRWHVAECLDTPGSVEKECPDGLLCTSTIPSHYKRYSHFLLAASRAGEYLVNSTANTVERKMTCSTAAKSSCFPSPVEDSQAEKPSKNLKNVPNNECTSKIKDSEQRKSLNITSESTSSFADVQKPQQVFQLTQTTDNSCKFEFYDFTSSQESVSEDLCSQKDTSQPSLLQSKADFSDWEISYSPLSTCEESEGEAEEEKEVKTSQNKLLKVQNFEGPESNTEVFKFKKQHCEEINTSSCLYHSEKSASQSHVDSKCSNSPCVDNQQEMLSAESSFPLNCNQEFQQPGLLSPAINTGNKESQDKGACVLDSVYSCLTRTQSLLLTEGGRSPLSQKNKVLRAPSVVLTNTDKMTADATEKGTCQESLQPAVKKEENLDSTGVCFPSPISKTVSSHSLASMNAKSSPAKELKQMDIGVFFGLKPKVKEESKGEACLSEGKQIPSSVAPSGKRPRQQKRKAEGSVEDLEAVEESSNKDGGDANVTSGGQRKWRKRFRESSTTDEGARKKQCPFYKKIPGTGFTVDAFQYGEIEGCTAYFLTHFHSDHYCGLTKNFVFPLYCNKITGNLVKSKLRVKEQYINVLPMDTECIVNGIKVLLLDANHCPGATMILFYLPSGTAILHTGDFRADPSMERYPALIGQKIHTLYLDTTYCSPEYTFPSQQEVIQFAVNTAFEMVTLNPRTLVVCGTYSIGKEKVFLAIAEVLGSKASMSRDKYKTLQCLESAAVNSLITMNWDGTLLHILPMMQINFKGLQDHLNKFSENFDQVLAFKPTGWTYSDSCLSVMDIKPQTRGNITIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGDWRARSLMEKHFRDWMIEGSGHK