DCL1

Endoribonuclease Dicer homolog 1

1909 amino acids

Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of natural siRNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving 24 nucleotide nat-siRNAs into 21 nucleotide nat-siRNAs. Can produce RDR6-dependent endogenous ta-siRNAs derived from TAS1 and TAS2. Required for the production of 30-40 nucleotide bacterial-induced long siRNAs (lsiRNA). Acts redundantly with DICER-LIKE 3 (DCL3) to promote flowering via repression of FLOWERING LOCUS C (FLC). Represses antiviral RNA silencing through negative regulation of the expression of DCL4 and DCL3.

Belongs to the helicase family. Dicer subfamily.

213.574 kDa

MVMEDEPREATIKPSYWLDACEDISCDLIDDLVSEFDPSSVAVNESTDENGVINDFFGGIDHILDSIKNGGGLPNNGVSDTNSQINEVTVTPQVIAKETVKENGLQKNGGKRDEFSKEEGDKDRKRARVCSYQSERSNLSGRGHVNNSREGDRFMNRKRTRNWDEAGNNKKKRECNNYRRDGRDREVRGYWERDKVGSNELVYRSGTWEADHERDVKKVSGGNRECDVKAEENKSKPEERKEKVVEEQARRYQLDVLEQAKAKNTIAFLETGAGKTLIAILLIKSVHKDLMSQNRKMLSVFLVPKVPLVYQQAEVIRNQTCFQVGHYCGEMGQDFWDSRRWQREFESKQVLVMTAQILLNILRHSIIRMETIDLLILDECHHAVKKHPYSLVMSEFYHTTPKDKRPAIFGMTASPVNLKGVSSQVDCAIKIRNLETKLDSTVCTIKDRKELEKHVPMPSEIVVEYDKAATMWSLHETIKQMIAAVEEAAQASSRKSKWQFMGARDAGAKDELRQVYGVSERTESDGAANLIHKLRAINYTLAELGQWCAYKVGQSFLSALQSDERVNFQVDVKFQESYLSEVVSLLQCELLEGAAAEKVAAEVGKPENGNAHDEMEEGELPDDPVVSGGEHVDEVIGAAVADGKVTPKVQSLIKLLLKYQHTADFRAIVFVERVVAALVLPKVFAELPSLSFIRCASMIGHNNSQEMKSSQMQDTISKFRDGHVTLLVATSVAEEGLDIRQCNVVMRFDLAKTVLAYIQSRGRARKPGSDYILMVERGNVSHAAFLRNARNSEETLRKEAIERTDLSHLKDTSRLISIDAVPGTVYKVEATGAMVSLNSAVGLVHFYCSQLPGDRYAILRPEFSMEKHEKPGGHTEYSCRLQLPCNAPFEILEGPVCSSMRLAQQAVCLAACKKLHEMGAFTDMLLPDKGSGQDAEKADQDDEGEPVPGTARHREFYPEGVADVLKGEWVSSGKEVCESSKLFHLYMYNVRCVDFGSSKDPFLSEVSEFAILFGNELDAEVLSMSMDLYVARAMITKASLAFKGSLDITENQLSSLKKFHVRLMSIVLDVDVEPSTTPWDPAKAYLFVPVTDNTSMEPIKGINWELVEKITKTTAWDNPLQRARPDVYLGTNERTLGGDRREYGFGKLRHNIVFGQKSHPTYGIRGAVASFDVVRASGLLPVRDAFEKEVEEDLSKGKLMMADGCMVAEDLIGKIVTAAHSGKRFYVDSICYDMSAETSFPRKEGYLGPLEYNTYADYYKQKYGVDLNCKQQPLIKGRGVSYCKNLLSPRFEQSGESETVLDKTYYVFLPPELCVVHPLSGSLIRGAQRLPSIMRRVESMLLAVQLKNLISYPIPTSKILEALTAASCQETFCYERAELLGDAYLKWVVSRFLFLKYPQKHEGQLTRMRQQMVSNMVLYQFALVKGLQSYIQADRFAPSRWSAPGVPPVFDEDTKDGGSSFFDEEQKPVSEENSDVFEDGEMEDGELEGDLSSYRVLSSKTLADVVEALIGVYYVEGGKIAANHLMKWIGIHVEDDPDEVDGTLKNVNVPESVLKSIDFVGLERALKYEFKEKGLLVEAITHASRPSSGVSCYQRLEFVGDAVLDHLITRHLFFTYTSLPPGRLTDLRAAAVNNENFARVAVKHKLHLYLRHGSSALEKQIREFVKEVQTESSKPGFNSFGLGDCKAPKVLGDIVESIAGAIFLDSGKDTTAAWKVFQPLLQPMVTPETLPMHPVRELQERCQQQAEGLEYKASRSGNTATVEVFIDGVQVGVAQNPQKKMAQKLAARNALAALKEKEIAESKEKHINNGNAGEDQGENENGNKKNGHQPFTRQTLNDICLRKNWPMPSYRCVKEGGPAHAKRFTFGVRVNTSDRGWTDECIGEPMPSVKKAKDSAAVLLLELLNKTFS

DCL1

Endoribonuclease Dicer homolog 1

1883 amino acids

Involved in the RNA silencing pathway. Cleaves double-stranded RNA to produce microRNAs (miRNAs) of 21-24 nucleotides which target the selective destruction of complementary RNAs. Regulates by this way the development of the plant. May not be involved in small interfering RNAs (siRNAs) production.

Belongs to the helicase family. Dicer subfamily.

210.203 kDa

MAGGGGVGGGAGEHAAAAYWYDACEDGASLLCGIDFAASADFDPGLIPAMDTGADDGFVAEIDRILESINAESSPAPPPPPPPPLPEPVPVAPPELPIQEKQLQVASAPVANNAVAVVGVVQRSKGVVARKEPRRESHGCAANGGGGGEWRDGKRPRLASGGVGGPRQEWRRRPMLPPPPSRGWDDRRGRRDFDRVRKHEHHRREARGFWERDRGGKMVFRSGTWEQESDREAKRARTQDGGSMEKKAEADRMGAAQREKPVAEERARQYQLEVLEQAKSRNTIAFLETGAGKTLIAVLLIKSVCDKMLKENKKMLAVFLVPKVPLVYQVLVMTAQILLNILRHSIIKMDAIHLLILDECHHAVKKHPYSLVMSEFYHTTPKEKRPAVFGMTASPVNLKGVTSQEDCAIKIRNLESKLDSVVCTIKDRKELEKHVPMPLEVVVQYDKAATLWSLHEQIKQMESTVEEAALSSSKRTKWQFMGARDAGSRDELRLVYGVSERTESDGAANLIQKLRAINYALGELGQWCAYKVAQSFLTALQNDERANYQVDVKFQESYLKKVVDLLHCQLTEGAAMKSETSDVEMQNTEKHNTNDLEEGELPDSHGEHVDEVIGAAVADGKVTPRVQALIKILLKYQHTEDFRAIIFVERVVTALVLPKVLAELPSLSFIRCASLIGHNNNQEMRACQMQDTISKFRDGRVTLLVATSVAEEGLDIRQCNVVIRFDLAKTVLAYIQSRGRARKPGSDYILMLERGNISHETFLRNARNSEETLRKEAMERTDLSHLDGTSVLSPVDTSPGSMYQVESTGAVVSLNSAVGLIHFYCSQLPSDRYSILHPEFIMQKYEKPGGSVEYSCKLQLPCNAPFEKLEGPICSSIRLAQQAVCLAACKKLHEMGAFTDTLLPDRGSGEGEKTEQNDEGEPLPGTARHREFYPEGVADILRGEWILSGRDGYQNSQFIKLYMYSVNCVNVGTSKDPFVTQLSNFAIIFGNELDAEVLSTTMDLFVARTMITKASLVFRGRIEITESQLVLLKSFHVRLMSIVLDVDVDPSTTPWDPAKAYLFVPVGAEKCTDPLREIDWTLVNNIVNTDAWNNPLQRARPDVYLGTNERTLGGDRREYGFGKLRHGTAFGQKAHPTYGIRGAIAEFDIVKASGLVPARDRGHFSDYQNQGKLFMADSCWNAKDLAGMVVTAAHSGKRFYVDCICYNMNAENSFPRKEGYLGPLEYSSYADYYKQKYGVELIYRKQPLIRARGVSYCKNLLSPRFEHSDAREGDFSENLDKTYYVYLPPELCLVHPLPGSLVRGAQRLPSIMRRVESMLLAVQLKDIIDYPVPATKILEALTAASCQETLCYERAELLGDAYLKWVVSRFLFLKYPQKHEGQLTRMRQQMVSNMVLYQYALNKTLQSYIQADRFAPSRWAAPGVLPVFDEESREYEPSIFDEESTGCELQKESYDDYADNMQEDGEIEGDSSCYRVLSSKTLADVVEALIGVYYVAGGKIAANHLMKWIGIHAELDPEEIPPPKPYDIPESIMRSINFDTLKGVLGIEFQNKGLLVEAITHASRPSSGVSCYQRLEFVGDAVLDHLITRHLFFTYTDLPPGRLTDLRAAAVNNENFARVAVKHKLHVHLRHGSSALETQIREFVKDVQEELLKPGFNSFGLGDCKAPKVLGDIVESIAGAIFLDSGYDTSVVWKVFQPLLHPMVTPETLPMHPVRELQERCQQQAEGLEYKASRAGNIATVEVFVDGVQIGVAQNPQKKMAQKLAARNALVVLKEKETATKKEDERDGEKKNGAQMFTRQTLNDICLRRQWPMPQYRCVNEGGPAHAKRFVYSVRVNTSDRGWTDECIGEPMPSVKKAKDSAAVLLLELLNRDFPDKPDGKQP

DCL1

Dicer-like protein 1

1607 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

181.289 kDa

MNAEMREGSSALPQLQAHSPVADNIDLMDIDEPASNGSFEESPATPFDDDAFVNAGDTDQEDDDPDTKKWIVNDSRKPRKISEKKRADHAAFDVWIEENQQDLSKGLDKFIVDDDGKTFQSLIRDFENKRIITSPRDYQLELFERAKTQNTIAVLDTGSGKTLIAALLLRWTIQNELEDRSKRLPKRIAFFLVDKVALVFQQHAVLACNLDYPLEKFCGDMVEDVTQDFWHKTFDENMAIVCTAEILYQCLTHSYIRMDQVNLLVFDEAHHTKKNHPYARIIKDFYAEVKDLNKRLRISRAMTASPVDAQIDPKIARSPELEGLLHSQIATVADPTALHNSSTKLKREVTVEYGKCLPEFETGLNRALKDLVGEHRLFQKPFAFTATAASELGPWCADRYWQLFFRGEEVVKLEAKTEREILRKSAYSQEIAAQVNKVREAHRLVGQHEFASPSSDLLSSKVVILLRILRGEFRGVDHKRRCIVFVRQRNVASLLTDLLQQPEMRIPGLEPGILVGGGRPEASYDNAKVTYRDQVLTIIKFKKGELNCIFATSVAEEGLDIPDCNVIIRYDLNNTLIQYIQSRGRARQEGSIYIHMVESENEEHVKKVCQNQESEDALRKFCEALPADRKLTGNNFDMEYFLRKEKDQRQYTVPETGARLNYKQSLICLAAFVASLPHPPEVNLTAGYLVLSVPGGYQCEVTLPESSPIRSATGKVYASKAVAKCSAAYEMCLMLIKGKYLDQHLRPTFTKQLPAMRNARLAVSSKKKEQYKMRIKPELWSVLGEPTELFAMALTLADPTALARHSSPLLLLTRQPIPQIASFPLYFGKNRSSAVHCVPVPGRVELDDNQIQGLVAVTLAIFKDIFSKEYEATAAQLPYFLAPTLMQHGSDFTSVTDLSRIVDWGAVTFVRDNERVAYALDDEADEFFKNKYVADPYDGSRKFFLRGRRHDMKPTDMVPEGIVTPGHRAWRVSCKTHDILNYSLSAWSKSRAFLTPREDQPVVEAEVLPIRRNLLDDHIGDDDLEPKPCFIVLEPLRISPLPVDLVAMAYNFPAIMHRIDSNLVALEACKMLNLNVRPDLALEAFTKDSDNSGEHDAEQISFQSGMGNNYERLEFLGDCFLKMATTISIFTLIPDKAEFEYHVERMLLICNRNLFNNALEVKLEEHIRSMAFDRRSWYPEGLTLKKGKRKDLTRQHVLADKTIADVCEALIGAAYLTAQEQTPPNFDLAIRAVTVMVKDKNHTMTSYSDYYAAYSPPAWQTAPCNSTQLDMAARFEARMGYAFTHPRLLRSAFQHPTYPSVYEKLPSYQRLEFLGDALLDMASVEFLFHRFPGADPQWLTEHKMAMVSNQFLGCLAVYLGFHRAISYCASAIQKEITEYVTEIEDALQSARDDASKTPCNRHATTPSPGDLPAESFARDFWVRCSRPPKCLPDVVEAYVGAVFVDSRYDFARVRAFFADHVRPFFEDMRLYDAFANKHPVTFLAGIMQGRMRCAEWRLLVKDLPPVVGAGAGTELETPQVVCAVRVHGLTLAHAVAASGRYGKIAAAKKAIQVLEGMDAEAFRKAYGCACVLGEEEQQAAQTIATELEVFPAFSASGLEVAHHGSAV

DCL1

Dicer-like protein 1

1591 amino acids

Dicer-like endonuclease which seems not to be involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway, contrary to its DCL2 counterpart.

Belongs to the helicase family. Dicer subfamily.

180.666 kDa

MEVHDGLKSPDKAAKSRYDDDRIDQDSEDEAVRLVANPDPSKPRKISERKRADQAAFESWVNDNKIRLSLPSATKSRRSGIRELFSSDETLETRPTRTRPRERVIEGPREYQIELFERAKQKNTIAVLDTGTGKTLIAILLIRHIIELELGARWQGREKRITFFLVDKVALVRQQTDHIRANLDFPVTGLHGDTVRNLWYSKEYFEKLLQEQEVVVCTAEILYRCLHRSYLNISQVSLVVFDEAHHAKKNHVYARIIKDFYLMEEDCQKRPRIFGMTASPIDTKDTCISYERATHELESLLHSEIATISDRDLLKVIGSRPQEVRKSYARVLRQENTELCNQLRELVGNHPLFKQTFDSAEFAVTELGAWCADKLWELCFREEAVSTLDGRVEGSRARDPDEVGESSHEVSNAREALSLVQQWSFSPPEDGSLSTKTHKLIEILAECFSQASAGNAIQCIVFVKRRDTAVLLNALCEQAEIRTKIPDLKGAFLIGAGRGGNAAFTTTRQQEQTVSRFRDGEINCLFATSIAEEGLDIPGCNVVIRFDLHGTTIQYIQSRGRARMRNSWFIHMTEFGNPEHNRRWFQDRVNEQKMRDFCLSLPKDRIMEKAEVDDVLRGDQSQKIFVVPGSKASLTFKQSLVVLAEFVATLPARPDEILSVDYTVVPVFGGFQGEVYLPASSPLRSAMGGVYRSKQLAKCAAAYAMCIQLYNSNYLDDHLKSTLAKVLPAMRNARLAVSSKKRKSYNMRTKPVLWSEVGPLTELYAMVLSLAQPGAAYYHSRPILLLTRKPLPEIAQFPLFFGKGSSRRSNVRCIPLAHPWSPTTTQVEGICAFTLCIFRDIFSKDFQASGTDMPYFLAPSTGIEHGTDLSSLVNPERIIDWATVHRTTTTDRVPYNFNEPDEFFQDKYVSDPFDGSRKFFMRKVRRDLKPQDKVPEGVPAPSKWRAVEHTILNYSVSLWKKSRAGHNSRQDQPVVEAELAPLRRNLLDETDGENSTGPQTCYLVLETLLISQIPVDTVVMAYTFPAIIYRLENSLISLEACQNLGLDIPIDIALIAMTKDSDNSDDHDEAPINFQSGMGQNYERLEFLGDCFLKMATSIALYTLVEGDEFEYHVERMLDICNKNLLNWALESNLQEHIRSKSFNRRTWYPPGLKLLKGKKTEVDDEHALGDKSIADVCEALIGAAYLTAQAQSSPNFDLAVKAVTVMTHSKTHTMQAWSDYYASYQCPEWLSTPPSQTQLELCSQIKNKMGYRFKNPRLLRCAFMHPSYPRQYENIPSYQRLEFLGDSLLDMVCVDYLFKKHPDKDPQWLTEHKMAMVSNQFFGCVAVGLGFHRHLIHMQPALGGSITEWAELVTKKREEARQLAVRRGQREEDYARDFWIEVHHPPKCLPDILEAYVGALFVDTGYDYSAVVGFFDRHIKPYFADMSIYDMYSSKHPVTHITSIITTQFGCSSFRLMVHEIPDDVQGEGLVTGAVKVVAACMIHGEVRCHAVAASGRYAKLAVAKQAVAIYEDMSPTEFRLRHGCNCKPEDGDGDHGVLVDHRADCEPEEPLRKQDPPAKSVVDVDGKTIAEMRLRHSKQMNDQEECLSW

dcl1

Dicer-like protein 1

1538 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

174.902 kDa

MTEQISLVDVSSSVSLKGEDSSNVALLRDLFINDVAASDPAESSADVHKDEHSSDNSDNDNEAVPKPNDFSQRRRIQNAQFEALLSKRTDADSNEAIDRAPIALSDDELSIAHLVEKQDLGNGMLDPREYQIELFERAKTQNTIAVLDTGSGKTLIAVLLLRHTILNELDNRANGKPHRVSFFLVDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWDKRTWDEHLQRNMVIVCTAEILNQCLLNSYVKMDQINLLIFDEAHHAKKDHPYARIIRDSYFKAQPSQRPRVFGMTASPIDTKGDITEAATRLETLLDSRIATTSKITLLREVVSRPIEKVWAYNRLESPFATELYKLMDTRYGNIKVLEGVYRFAWHASSELGKWCSDRAWWHALADDVLPKLEGNISKLVESNTLNAEHGAVFKDIIRIREASETVKNYSFADPELPGELSPKVQLLRMELSKHFSDTTGTKCIVFTQKRYTAKILNELFTVLNIPHLRPGVLIGVRPGDIGGMNVTFRQQFLALVKFRTGEINCLFATSVAEEGLDIPDCNLVVRFDLYRTLIQYVQSRGRARHCTSTYAIMVEKDNAEHEGRLKEIREAEKIMQRFCETLPEDRILHGNDHDLDSLLQEEEGRRTFTVKSTGAKLTYHSAIAILARYASSLQYEKETVPQVTYVVGHVSNAYVCEVILPEKSPIRGLTGSPAIRKAVAKQSAAFDTCLLLRKHRLLDDYFNSIYHRRLPAMRNAKLAITCKRTNEYDMLLKPSIWAKQRTTPIDKLYGIHISLLPSKPLSRDHRPILLLTREKLPEFPAFSIYLDEDVETKVLSYPLKHGLQISVDELQSLTTFTLRIFRDIFHKVYEHEVQKMPYWLAPAKALDGPGSGTNPRDWTDWDTVSFVHNNDEIPFTRDLNPDSLVNRFIFDNWDGRFRYFTVAVADTLQPSDPPPPSVPRRRHMNNIMNYTLSLSKNSRARFFSGCDWNQPVLQAELVRLRRNLLDKMTTQEKEMQTECFICAEPLRISAIPTSIVSTCLAFPAIISRLDSYLIALEACDELELVIRPDFALEAFTKDSDNTEEHRGQQIHFQRGMGKNYERLEFLGDCFLKMATSIALYTQNPDDDEFDYHVNRMCLICNKNLFNTAIKKQIYRYIRSRGFSRHIWYPDGLTLLHGKDHSKKLLSEGKHALGEKTIADVCEALIGASLLSGGPENRFDMATKAVTALVDSPSHRVSCWKEYITLYTMPKYQTEKPRGSEDDLARHVEEELGYHFTYPRLLASAITHPSLPSTWGYRVPCYQRLEFLGDSLLDMVCVEDLFRRFPDRDPQWLTEHKMAMVSNKFLGALSVKLGFHRRIMAFSNPLQAQITHYVEEIESAQAESRGAVDYWVVAKDPPKCLPDMVEAYLGAIFVDSKFDFQVIEVFFERQIKPFFEDMSIYDTFANKHPTTFLHNKLTNEYGCTNYCLKAGELPTIDGAPAGVLAAVIVHGNVISEARSSSSRYAKVKASEKALAVLDGLLPFEFCQKYHCGCKETQNSSSAVEIGTAI

dcl1

Dicer-like protein 1

1537 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

175.123 kDa

MAEQISLVDVSSSVSLRGEDSSNVALLRDVFLPDVAASDPAESSVDVQDEHSSDDSDNENEVFPKQNDFSQRRRIQNAQFEALLSKCTDADSNEAFDRAPIALSDGELSIAHLVKKQDLGNGMLDPREYQIELFERAKTQNTIAVLDTGSGKTLIAVLLLRHTILNELDDRANGKTHRVSFFLVDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWDKRTWDKHLQRNMVIVCTAEILNQCLLNSYVRMDQINLLIFDEAHHAKKDHPYARIIRDSYFKAQPSQRPRVFGMTASPIDTKGDITEAATRLETFLDSRIATTSKITLLREVVSRPIEKVWAYNRLEPPFATELYKLMDTRYGNIKVLEGVYRFAWNASSELGKWCSDRAWWHALADDVLPKLEGNINKLIESNTMKAEHGAVFKDIIRIREASETVKNYFFTDPELPGELSPKVQRLRMELSKHFNDTTGTKCIVFTQKRYTAKILNELFTVLNIPNLRPGVLIGVRPGDIGGMNITFRQQFLALVKFRTGEINCLFATSVAEEGLDIPDCNLVIRFDLYRTLIQYVQSRGRARHCTSTYAIMVEKDNAEHEGRLKEIREAENIMRRFCEILPEDRILHGNDHDLDSFLQEEEGRRTFTVKSTGAKLTYHSAIAILARYASSLQYEKETVPQVTYVVTIASNAYVCEVILPEKSPIRGLTGSPAMRKAVAKRSAAFDTCLLLRKNRLLDGYFNSIYHRRLPAMRNAKLAITCKRTNAYDMLLKPSIWAKQRTTPTETFYGIHMSLLPSKPLSRDHRPILLLTREKLPEFPAFSIYLDEDVETKVLSYPLKHGLQISVDKLQSLTVFTLRIFRDIFHKVYEHEVQKMPYWLAPAEAIDGRGSGKNPRDCIDWDTVSFVHNNDEITFTRNLNPESLVNRFIFDNWDGRFRYFTVAVADTLQPSDPPPPSVPRRRYMNNIMNYTLSLSKNSRARFLSSCDWNQPVLQAELVRLRRNLLDKMTTQEKEMQTECFICAEPLRISALPPSIVSTCLAFPAIISRLDSYLIALEACDELELVIRPDFALEAFTKDSDNTEEHRGQQIHFQRGMGKNYERLEFLGDCFLKMATSIALFSQNPNDDEFDYHVNRMCLICNKNLFNTAIKKQIYRYIRSRGFSRHIWYPDGLTLLHGKDHSTKLLSEGKHALGEKTIADVCEALIGASLLSGGPEHRFDMATKAVSALVDSPSHRVSCWKEYITLYTLPKYQTEKHRGSEDDLARHVEEELGYHFTYPRLLASAITHPSLPSTWGYRVPCYQRLEFLGDSLLDMVCVEDLFRRFPDRDPQWLSEHKMAMVSNKFLGALSVKLGFHRRIMAFSNPLQAQITHYVEEIETAQAESQGAVDYWVVAKDPPKCLPDMVEAYLGAIFVDSKFDFQVIEAFFERQIKPFFEDMSIYDTFANKHPTTFLHNKLTNEYGCTNYCLKAGELPTIDGAPATVLAAVIVHGNVISEARSSSSRYAKITASEKALAVLDGLLPSEFCQKYRCDCKETKNSSSVVEIGTAI

dcl1

Dicer-like protein 1

1534 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

174.094 kDa

MSSDLISQAESISNIEILRALFITDTHTTVGDVAVPSAEPGVEHDQISPGESDEEIEENISDQNNSSSQKRLQNAQFEALLTRRAEDTSNENIDRVPLNLSDNELSIAHLVAKQDVGGGLLDPREYQIELFERAKAQNTIAVLDTGSGKTLIAVLLLRHVLQNELNDRANGKPHRVSFFLVDSVTLAYQQAAVLRNNIDQNVAHFFGAMGTDLWDRQVWEEHLQQNMVIVCTAEILNQCLLNSHVRMNQINLLIFDEAHHTKKDHPYARIIRDSYFKASPPQRPRIFGMTASPIDTKGDIIAAATRLETLLDSRIATTSKITLLRQVVSRPIEKVWAYDRLESPFKTNLHKLMENRFGNVKALEGVFRFAWYASSELGRWCSDRAWLYALADDVLPKLEGHVNKLAESTAAATERDMAFKEITLIKEASNIVKAHTFNDPEFPGELSPKVRLLQTELSKHFSHAPETKCIIFTQKRYTAKTLHELFTILSIPHLRPGVLIGVRSGDIGGMNITFRQQFLALVKFRKGEINCLFATSVAEEGLDIPDCNLVVRFDLYHTLIQYVQSRGRARHYHSTYASMVEKDNSDHEARLREVREAEKTMQNFCETLPEDRILHGNDHDLDSLLQHEEGRRTFTVKSTGARLTYHSAIAILARYASSLQYEKETTPQATYVVQSVGNTYVCEVILPEKSPIRGLTGSPAIRKSIAKQSAAFDTCLLLRRHKLLDDFFKSIYHKRLPAMRNAKLAITSKKTNQYDMLLKPSIWRRHQGILPSKLYGTILSLLPSEPLSREHQPILVLTREKLPDFPAFPIYLDEDIETKVVPRSLDTGMELSAEELRALTTFTLRIFRDVFHKVYEQESEKLPYWLAPAEPLDANGREPGPRGIIDWKTVTFVQENDEIVFSRDLAPESLVNRFMFDKWDGRSRFFTIKVMEGLRAADPPPSSVPRRRHMDNIMSYCLSLSKNSRARFLAGCHWDQPVLQAELVRLRRNLLDKLTTEEKKIQTECFICAEPLKISAIPPSIASTCLAFPAIITRLDSYLISIEACDELDLVIRSDYALEAVTKDSDNTEEHRGQQIHFQRGMGKNYERLEFLGDCFLKMATSIALFTQNPDDDEFDYHVNRMCLICNKNLFNTAKKRQIYRYIRSRSFSRHVWYPDGLTLLQGKDHSKKMLSQAKHALGEKTIADVCEALIGACLLSGGPEHRFDMGVKAVSVFVDSPSHAVSRWKEYIGLYKPPNYQVRKAEGAETNLALQVEEKLGYHFRYPRLLCSAVTHPSTPSTWYFRVPCYQRLEFLGDSLLDMVCVEDLFHRFPDRDPQWLTEHKMAMVSNKFLGALAVKLGFHKHIKAFSNPLQAQITYYVEEIETAEAESEGAVDYWVVAKDPPKCLPDMVEAYLGAIFVDSDFSFEVIEAFFQAQIKPYFQDMSIYDTFANKHPTTFLHNRLANEFGCTNYCLKAGEMPAIDGMPAGVLAAVIVHNSVVSEATASSSRYAKIRASERALVVLDGLLPYEFRQRYNCNCQVVGNPASAPDIGTAI

dcl1

Dicer-like protein 1

1525 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

173.497 kDa

MPSAHAFDMRITSDIYKPDQHLPMETMKVCAVTMTEDLQEDDGSSDESDNDEREDHSKTGVSQQRITQNAKFKALLAQRADTGPIHDVSVTHDLPDAQLSTAHLVAKQDLGIGTLDPREYQLELFERAKVQNTIAVLDTGSGKTLIAVLLLKHTLEKELNDRMEGKPHRIAFFLVDSVTLAYQQAAVLRNNLDQSVGHFFGAMGTDLWSKSVWDQHFQKNMVIVCTAEILNQCLLNSYIKMSQINILIFDEAHHTKKDHPYARIIRDSYLEEVYSKRPRIFGMTASPIDTKGDIVDEATRLEKLLDSRIATTSNMSLLRQVARRPVERVWSFNKLEQPFATSLYKHLEDRFGDMACLEGIFRFAWQASSELGRWCSDRAWARALADDVLPKLEGSVRKTANSETSSNVPESAYKEILRITEASEIVKSYAFSSPETFGQLSPKVQVLREELARYFGRQTETKCIVFTQKRYTALILAELFQTLNIPFLRPGVLIGVRSGDLAGMNITFRQQFISLVKFRTGEINCLFATSVAEEGLDIPDCNLVVRFDLYQTLIQYVQSRGRARHFNSTYASMVERGNLEHEQRLLEVQDAEMMQSFCRTLPEDRLLYGFDHDLDTVLQKDEGNRTFRIKSTGAKLTYHSATAILARYASSLQYEKEFSAQVTYVVLPINGAFVCEVILPEKSPIRGLTGSPAMKKSIAKRSAAFDTCLLLRKNKLLDDHFNSIYHRRLPAMRNAKLAITSKRTSQYDMISKPSLWGRKQGMPPKELHGTFITFLPSMQLSHEPAPLLLFTRERLPHFPEFPIFLDDDVETTIITTPLEKQLLLSEKEVDALTVFTLRVFRDVFHKTYDKEPEKMAYWLAPAKVQSSYLPSYDPRQILDWESLTYVRDNDSIPFSTNADPESWVDLFVFDAWDGRCRFFTVGVEHSLTPSSPPPPFVARRRHMNDVMNYCLSLSKNSRAKFLSTCHWDQPVLRAELVRLRRNLLDKMTDTERDVETRCFICIEPLKVSAIPASTAFSCLAFPAIISRIDAYLISLQGCESLNFTVKLDLALEAFTKDSDNTDEHRAQQIHVQRGMGRNYERLEFLGDCFLKMATSIALFTQNPDDDEFDYHVNRMCLICNKNLFNAAVDKEIYKYIRSRGFSRHTWYPEGLKLLQGKDHSRKATTESKHALAEKTIADVCEALIGAALLSGGPDHRFDMAVKAVTTLVNSPSHKAERWKDYISFYTIPKYQRRAADGAELYLSRKIEEKLSYRFRYPTLLGSAFTHPSYPSAWAKVPCYQRLEFLGDSLIDMVCVEDLFARFPDRDPQWLTEHKMAMVSNKFLGALAVKLGLHTHLKYFSAPLQSQITQYAEEIQTAEGESEGAVDYWTVTKDPPKCLPDMVEAYVGAVFVDSDFNFEVIERFFRDYIKPFFEDMAIYDTFANKHPTTFLHNRLTNEFGCVNYCLKAGEMPSIDGAPAGVLAAVIVHDVVIAEGTATSGRYAKVKASEKALAVLDEISSAEFQRKFRCDCRESGDSARLDIGTAI

dcl1

Dicer-like protein 1

1523 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

172.531 kDa

MPPLEVKPLAGYVRSQSLRIPSSLNLSGERTISTTEPTEGNDSSSEESGDNEQISTQRLISQNKRLQSAKFEALLSERADTLTGNSGRPTLDLPDAELSTASLVAKQDAGTGMLDPREYQVELFERAKSQNTIAVLDTGSGKTLIAVLLLKHIIQNELIDRANGKPPRISFFLVDSVTLAFQQAAVLRNNLDQNVAQFFGAMGTDLWSKQTWDHQFENNMVIVCTAEILNQCLLNSYIRMDQINLLIFDEAHHTKKDHPYARIIRESYLKADPTKRPRIFGMTASPIDTKGDIIESATKLEVLLDSKIATTSKPNLLREVVRRPIEESWEYDKLDPPFATKLYQILQARFGDISSLQPVFRFTLQASSELGPCCADRAWAYALADDVLPKLEGNVRKLAQSISSPIPQCALKEISRIQEASDIVKNHSFNSPNVPGELSPKVQLLRQKLIKYFEHPTKTKCIVFTQKRYTAKMLFDLFSTLEIPYLRPGVLIGVRSGDIVGMNVSFRQQFLALVKFRSGEINCLFATSVAEEGLDIPDCNLVVRFDLYNTLIQYVQSRGRARHSSSTYASMIERYNADHAARLVEVREAEKLMQSFCETLPEDRILHGIDSEIDSILQGEEEKRTFIIRATGAKLTYHSALAILARYASSLQYEKETSAQATYVVLPQNNSFVCEVILPEKSPVRGLTGVPASKKSAAKQSAAFDTCVLLRKHKLLDDHFNSVYHRRLPAMRNARLAITSSRTNQYDMLSKPSLWGKQQGTLPEKLFATVISFIPSEPLRRRHRSIILLTRERLPDFPSFTIFLDDDIETIVVTESVEEALHISSQELEYLSTFTFRIFHDVFHKTYAEEPEKLPYWVAPAETKKSKNVSDSKSLTDWELLHLVHENEEIPSTLHPSSEALINRFVFDPWDGRYRYFTMAIDNTLHPSDPPPSFLPRRKFMESIMSYTLSGSKNARAGFLSRCNWQQPVLEVELVRLRRNLLDKMTDTEKDVETRCFVCIEPLRISAIPEEIAASCLAFPAIINRLDAYLIALEGCKTLDLSVKPEYALEAFTKDSDNTEEHRVQQIHVQRGMGKNYERLEFLGDCFLKMATSISLFVQNPDDDEFDFHVNRMCLICNKNLFNTALKKELYQYTRSRGFSRHTWYPDGLTLLHGRDHRKKISAESKHALREKTVADVCEALIGASLLSGGLHNQFDMAVKAVTAVVDSPNHKALCWADYTSSYMLPKYQTQSPDGYELDLGRKVEEKLGYRFKYPRLLHSAFTHPSYPSTWAKVPCYQRLEFLGDSLLDMVCVDDLFYRYPDKDPQWLTEHKMAMVSNKFLGALAVKLGLHTHLRHFSNPLQSQITHYAEEIQAAENESQGAVDYWLVTKDPPKCLPDMVEAYLGAAFVDSDFQFRVVEDFFQRHVKSYFHDMTIYDTFANKHPTTFLQNRLTNEYGCTNYCLKAGEIPVVDGGTVSVLAAVIVHEVVIAEGTASSGRYAKVKASEKALSVLENMGPSEFREKYHCDCRTANGSQPMDIGTAI

DCL1

Dicer-like protein 1

1522 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

175.115 kDa

MTWAGDVEEQDDYFSCSDVSTSGDRRKRAPQTVTQEEVDQATSKIANEGQLSIRDILASQDTAVRITNPRDYQMELFLRAKMQNTIAVLDTGTGKTHIATLLLRHVLEEELENRAKGCAHKMAFFLVDSVNLVFQQANVLRCGLDQGVEGISGAMGQSLFQKQTWDKLFAVNMVIVCTAQVLVDCMMHSFMSISRMNLLIFDEAHHAKSNHPYARVMKDYYAHELDTSKRPRIFAMTASPVDVKGQSAEHVREAARELETLLHSRIATTSDSALARNSITRPEEEVAVYTRLRNEFETPLHQKVKAKYGDVAPFRKLFITAKLHASELGRWASDMYWSFAFADEQSRKLQIREELKYNRSKRDWSAAELDAQMARLKEATAFVQQYEIGAPTLSEQDLSSKVMKLQYWLNLYYERTTLARCIVFVEKRHTAQLLKLIFDHIGGPNLHCDVLVGINNRAGEENVSLRSQILTLQKFRRGELNCLFATSVAEEGLDIPQCNLVVRFDLYRTMIGYVQSRGRARHRNSKYLHMLEAENKEHTERLMNARHDENIMREFCKDLTHDRQLGDVEQEKAELIALEDKLFPSYTDEKSGAKLTYRSSLSILSHFVATYPSPDHNTMAQPTYVVNPKISDDPRDPQRNGFVCEVILPEHCPIISMVGQVYSRKTIAKCSAAFKMCIELRRKDHLNEFLLPTISKYLPAMRNALLAVSEKKKGNYAMVIKPTFWKQDRDTVPESLHLTIIDADRGLDRPHQPLAMLTRRPFPQLPSFPIYLTDCRPSNIVSQSLHIPISLTPELLEMFTRFTLRIFEDIYNKVYDYDVSKMSYWMLPVIEHRVASVRSMSNPQEVLDMDQIRKVYNEPFWKWSPQSRTDDLIDRYFVDPMNGGRRYYSDRLAPHLKPQDPVPANVPRQNHKFMKNILDFSDSKWMKSRDITRWHQDQPVLQVEKIPFRRNHLANVEDKEKKELANLETYICPEPLHISNLATPFVVMCYVLPAIIHRFESYLIALDACDVLDLKVSPALALEALTKDSDNSEEHGEEKINFKSGMGPNYERLEFLGDCFLKVATSLSVFVQQPEENEFEFHVRRMLMLCNQNLMETAVGKKKLYKYVRTDAFSRRNWYPEGLKLLRGKGLKKTEEDWLNVTHNLGDKSVADVCEAFIGAAFMQHHKGGQWTPNDWDEAVKAVKLFANSDDHLMEKWTDYYAAYTKPKYQTAGATATQLDLAHKIEMKHPYRFRYPRLLRSAFIHPSQPFMWENIPSYQRLEFLGDSLLDMAFIMHLFYKYPDKDPQWLTEHKTPMVSNKFLGAVCVKLGWHTHMKQNTAILSSQIRDYVYEVEEAEREANGAVDYWVSVSEPPKCLADVIEAFVAAIFVDSEFDFNVVQKFFDLHLKPFFLDMTLDAYENFASNHPTTRLSRLLSINFGCSEWRMGALETETLIPGKGKAIAAMVMIHDKVHFHSLGQSGRYARVRASHAALEKLEGLPPYEFRSKYGCDCVDEGEGEAGVDEAAVSKKVELMREAIGPSI

dcl1

Dicer-like protein 1

1519 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

172.077 kDa

MTHQNTETASLATTKGALEPLPPDKTAGLSTGAGHEISSDESEGSEEETGLHKDPSQRQRQQNATFQAFLSHHAETIVNSPVKPNQAQSELSISSLIGRNASGTGILNPREYQIELFERAKVQNTIAVLDTGSGKTLIAVLLLKHVIQTELIDRANGNPPRISFFLVDSVTLVYQQASVLRNNLDQNVAHFFGAMGVDLWNKQTWAEHFEKNMVIVCTAEILNQCLLNAYITMQQINLLVFDEAHHTKKDHPYARIIRDSYLRVPPSSRPRIFGMTASPVDTKGDVLEAARNLEALLDSKIATTSKLTILRQVVNRPNEEVWIYDKLQPTFTSDLYKLMESRFGDISHLEPMFRFARHATSELGTWCADRVWVSALADDVLPKVEGSIGGKRQSTGLGQLPKDVHRDITRIKEASELVESHPPNDPGAPEALSSKVRVLWKEISQCFGQETNTKCIVFTEKRYTAKVLFDLFTVLNVPGLRPGVLIGVRSSDRIGMNVTFRQQILTMVRFRTGEINCLFATAVAEEGLDIPDCNLVVRFDLYKTLIQYVQSRGRARHADSTYASMIEKDNADHESILVQVNDAEKIMQSFCQLLPEDRILHGNDDDTDAVLDREEWEEPYTLPSTAARLTHHSAITVLARYASSLQYENDTSAQVTYVVLPVNDAYVCEVILPEKSPIRGATGMPAMKKSTAKRYAAFEACRLLRKHRLLDEYLNSVYHRRLPAMRNARLAITSHRTNEYKILPKSSLWNKQIGVIPGKLYGTVISLKPLTPLAREHGSMILFTRDRLPQFPTFPIFLGEDVETIVLTVPVNMELQPSADELDYMTTFTLRIFRDVFRKTYDKEPEKLPYWLLPAISFPCNQEADPRDVVNWEILSSVHERDDIEYQADMPPEMLVDRFVYDHWDGRYRYFTLAVDENLQPSSPPPSHVARRRHMDTIMNYSISLSKNSRAKFLSRCNWNQPVLHAELVRLRRNLLDRMTDKERKLETRSVICIEPLKISAIPAAIAATCLAFPAIISRLDAYLIGLEACKKLGLEISLEYALEALTKDSDNTHEHRSQQVHMQRGMGKNYERLEFLGDCFLKMATSISLFNQHPDDNEFDYHVNRMCLICNRNLFNSAVKKELYQFIRSRGFSRDTWYPEGLTLLQGRDHSKKIGSESKHALAEKTIADVCEALIGAALLTPGPQHRFDMGVRAVSAVVDSNEHNAASWRDYISLYSIPKYQEQAPDGSEIDLCRRVEEKLGYHFRYPRLLHSAFTHPSYPSAWARVPCYQSLEFLGDALLDMVCVEDLFRRFPDRDPQWLTEHKMAMVSNKFLGALAVKLGLHTHLSYFSSALQSQITHYAEEAQAAASQSDVAVDYWTLTQDPPKVCLPDMVEAYLGAVFVDSNFRFEEVEVFFQQHIKPYFHDMAIYDTFANRHPTTFLHNKLTNEYGCLNYCLKAGEIPGADGDASTVLAAVIVHDTILTTGVASSGRYAKVKASENALTELLHIDRNEFRKRYQCDCVQENGEHGERDVGTPI

DCL1

Dicer-like protein 1

1500 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

170.58 kDa

MEEPQRINDEPNDSVVPDPAGPSEPAESDSEDEHTHPNNADEPSIRRKQNLRFKELLSARAEEITAEDIKEVIKATKDDELSMSNLLAKQDFASVIHDPREYQVELFEKAKKDNIIAVLDTGSGKTLIAVLLLKHIIEQELIDRSAEKPHRVSFFLVDSVTLVFQQAAVLQNNINQRVDKFCGAMETDLWNGETWERHLAKNMVIVCTAEVLYQCLLHAFVKMENINLLIFDEAHNAKKDHPYARIVKDFYLKDGNAKRPKIFGMTASPVDAKMDVVKAARNLETLLNSQIATASNLSLLRQSVPRPNEEVWSYDRLDQPFETRLYKELRSRFGDLRALEKLFTFSLKASSNLGAWCADWVWSYALTEESLPKLEGRAARTAMGNLPIAKIVRPEAEIQRIREASEIIRSHKFGDPAVRPELLSPKVRRLHHELLKYFERHTDTKCIVFTEQRHTARILCDLFSRIGTKHLRPGVLIGVRSDASGGMNISFRQQVLAVVSFRKGEVNCLFATSVAEEGLDIPDCNLIVRFDLASTLTQYIQSRGRARHMNSTFAHLVERDNFVHRESVNHLQSSEEIMKRFCISLPKDRILNSDDVDALYESDRNRKSYTVQTTGAKLTYSSSLVVLAHFANSLQYEKETSTVVSYYHRFTKNAFVCEVVLPEKSPIRGIVGKPASKKLIAKQSAAFETCLLLRKHGLLDDHFVSTYHKRLPAMRNARLAISSKKSNQYDMKVKPKLWETSRGIIPTSLNIVVLGFRPRRLLHREYHPLVLLTREKLPHFPEFPLYLEDDIECDVICSSISSGFQVSSHDLEVLTTFTLRIFQDIFHKVYDRDVGMMTYWLAPLNLSCDISSSASRDLLDWGILQFVFDNPEIPWSSSNSAAFFANRFVYDRWDGRYRYFTHGIDPSLRPSDPPPSSMARRRHMGNIMDYCLSLFKNARKKFLENCDWTQPVIKAEIIQLRRNLLDKRTNKEKIKEGDYYICLEPLTISAIPASVAAFAFAFPAIISRIESYLIALEACQELDLPISPELALEALTKDSDNTDEHRAQQIHFQRGMGKNYERLEFLGDCFLKMATSISLFAMNPDNDEYDFHVKRMCLVCNQNLFKTAVRFKLYAFIRSQSFSRRGWYPGGLTLLQGKGQSKGATENKHALADKTIADVCEALIGACCLLASKNHRFDIAVKAVTALVSSDDHNVLNWEQYSRLYSIPKYQTAVVDAAELDLAAQVKKKLGYDFKYPKLLRSAFTHPSYPSAWARVPCYQRLEFLGDALLDMACVEHIYHKHPDKDPQWLTEHKMAMVSNKFLGSVAVRLGLHSHLNHFSTSLQSQITNYVEEIEAAELESGDPPDAWTLTSDPPKCLPDMVEAYIGAIFIDSGFSFEVVEEFFQKFLKKHFEDMTIYDTYANKHPTTYLHNRLAIDFGCSNYCLKAGEVPYVDGPGTRVLAAVIVHDEVVAEGVASSSRYAKLKASEAALSKLEGLPPFRFREIYGCNCQAGQSEAGNE