dcl-1

Dicer-like protein 1

1584 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume.

Belongs to the helicase family. Dicer subfamily.

178.589 kDa

MAVATRLPFIPPEATSQIIGGDEDLIDLSQEDVVSDNDDRGNASDVESEDGVKRWTVNPEPKPKKISAKKLADTAAFNSWIEEHQETLARDQRKAAIEAARVAGVDVLPAIGFDSERIITSPREYQVELFERAKQQNTIAVLDTGSGKTLIAAMLLRWVITGELEDREKGLPRRIAFFLVDKVALVFQQHSFLTKNLDFPMEKLCGEMVEGVESKAFWKEALEQNEVVVCTAEILSTALHHSWIRMDQINLLIFDEAHHTKKDHPYARIIKNFYIDEQLERRPRILGLTASPVDAKVDPRRAAAELEALLHSQIATAADPAALQHTICKPKTELVVEYVRGRPDSETVLNKQLRKLVGGQELFKKPLNFTTSAASKLGTWCADRYWQLFFKQEDIVKLESRTERDLMKVAALDEITEKHVKQVREAHELVNAHTFSPAALDPTMLSSKVIMLVRILRDQFERGVGAQRCIIFVRQRNTAMLLADLLQQPEIKSHIPSIAAEVLVGGGTTGSSYVNAKINFQQQNRIIRKFKLGEINCLFATSVAEEGLDIPDCNIVIRFDLYDTLIQCIQSRGRARRPDSRYIQMIEKGNYEHHSRILRAKGAEDVLRKFCEALPEDRKLTGNHMNLDYLLRKEKGKRQYTVPDTGAKLSYMQSLVCLANFTATLPHPPETSLSPEYYITTVPGGFQCEVVMPDASPIKSAVGKVHLSKGVAKCAAAFELCLALLKAGHLDNHLQSVFTKQLPEMRNARLAVSSKKKTEYAMRLKPELWSVRGVVTQLFATAFVLENPDTLGRSSRPLLLLSRSALPEVASFPLFFGTKRFSKVRCVPIPGSVQADDTLVEQLTRFTLKAFMDVFSKEYEATAVNLPYFLSPMDGGHGFDFRLAKSPAHLIDRKALAYVSENEKVPYTFLEPDDFFQDKFVVDPYDGARKFFTHHRRHDMKPTDPVPDGIVAPNHRAWRGLGTTHDILNYSNSLWSKSRGFMIFQADQPVVEAALISTRRDFLDDTLRDEDVEPQQCFLILEPMRISPIPADVVAMLLCFPSIIHRVESNLVALDACKLLGLDLRPDLALEAFTKDSDNSDEHDAEKENFQTGMGDNYERLEFLGDSFLKMATTIAIYTLIPDKGEFEYHVERMLLICNKNLFNNALEIGLEEYIRSMSFNRRQWYPEGLILKKGKSKDARQRHVLADKSIADVCEALIGAAYLTGQEKGSFDMAIKAVTAMVKDKKHRMISYGDYYAVYQKPTWQTESANSAQRDMAKKFSERMGYKFKHPRLLRAAFQHPTYPSLYERLPSYQRLEFLGDALFDMVAVDYLFRKFPAADPQWLTEHKMAMVSNQFLCCLSFHLGFNKCIATMSPSILKDIAEYVTEIEEALETAKQEAINAGKTADEYSRDYWVHITHASRLPKCLSDVVEAYIGAIFVDSEYDYSVVQNFFNMHVLPFFEDMHLYDTFANKHPVTFVANMMAHKFRCNEWRSFAKELDTDVTEGRGGRGGNGAVAGEISEINPPKVVSALLVHGKTVVHAVAASGRYAKSAMAKKAIKLLEGMSVEEFRERLGCNCKGVPMEVDGGVPEADVDGEVHGTAV

DCL-1

Dicer-like protein 1

1548 amino acids

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

176.667 kDa

MGDPAAHEMADLERGFSSEDDAEYRSGDDEASKFVENEPSKRGKISQKKKIEQTNFAKWMDTNQKSLTRKAVKQSVNQDNSLAYMIRSWEGGEKIITSPRDYQMELFERAKQQNTIAVLDTGSGKTLIAALLLDHTVNQELEDRAKGLPRRIAFFLVEKVALAFQQHAVLECNLAHSVAVFSGESIKNTWTKGFWETQLADHEVIVCTAEILNQCLQYAYIRIDQINLLVFDEAHHTKKNHPYARIIKDYYASGKDRGLRLPRIFGMTASPVDALIDVRQAAIELEGLLHSRIATTADPDALRRAVGRPKKEIIYKYNPLVKPIQTMLTFKLRPLIANNKQFSKAFAFSEAAARELGTWFVDRMWQLFLEDEELLKLEAKTERSLSKDMAAPEVVEKHRNAVRSARELIRSHEFPKPEPGLLSSKLKTLSKLLEEYFTDSSIRCIVFVERRWTAKLLTDFFESHAAEIPGLKVGSLMGANAEGGSSQTSFREQIRTILSFKKGNTNCIFATSVAEEGLDIPDCNLIIRFDICKTMIQYIQSRGRARQADSTYIHLIEGGNGDHRRIMHQNAENEKLLRRFCNTQPEDRLLKGSDYDMDFFLRQERNQRQYTIKSTGARLTYKNSLPILQAFLNTLRNQDDYAEGMDLVADYSILSVQGGFICEVMMPPLSPVTSAIGKVYSTKQVAKCSAAFELCFQLIQKKFLDDHLRSKFVEKRHVMANARLAVSSKNKAKYDMRLKPQIWAELGVPEKLYATVLILSKPSALERPSRPLFILTRTPLPQLKPFLLFLGPVEQEMTSDLVCQVLNCPITPTEEDLQLLTKFTLKIFVDIFNKKYAANAQALPYFFAPTNKDHVFLFSNLQDPRNAVDWPLLRHVADRDAEAYTGDEPEEFFQDKYIVDPHDGARRFWLQGIRKDLTCTSPVPADVEHQPTHRQWKRREVPHDILHWSLTAWKATREAHENKWKENQPVVVGKYATLRRNFLADINETSKNPFCYFVLEPMRISPLPVDVVAMAYLLPSIIHRIEQNLIALDACRLLQLDIHPDLALEALTKDSDNQGEDERMDSIQAFEPVNFQPGMGANYERLELLGDSFLKMATTIAVFTLIPNKDEFDYHCERMVMICNQNLFGVAKSDDLKLHEYIRSKSFERGTWYPVLKLEFGKTHLKTLKQMDEHRLADKSIADVCEALIGAAYMTTRKHDDYDLAVRAVTRLVNHKQHPMTKWDDYHAAYVMPGWQTMPANAAELDMAQKIHEATGYQFKHPRVLRSAFRHPSRPYVFDKVPHYQRLEFLGDALFDMACVDYLFHIAPDEGPQWLTEHKMAMVSNQFLGCLAVSLGFHKFILHHHASIGSQIHEYVTEITEARRAAEDAAEAAGKPRSAYSRDYWVEAPQPPKCIPDVLEAYVGAIFVDSKYDYSVVQQFFHAHVLPFFASMRMYDTFANKHPVTFFTQYVFETFGCHAYGLHAEEMPVKDDTGLVTGKTQVVAGILLHGQVVEGAVRDSGRYAKIAAARKALDKLRSMTRQEFLDAYKCDCKPGEAAEDISESATAI