dbf4b

Protein DBF4 homolog B

784 amino acids

Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Specifically required during the initiation of DNA replication in egg and during early embryonic development. The complex cdc7-dbf4b phosphorylates mcm2 and mcm4 subunits and is required for cdc45 loading.

85.981 kDa

MASVISVLHGQVMQQDDEPPLAKRRRCREITFAGKSFYLDVPANRQTQLLTKAIGRLGGIIESFLSRDVDYVVTGSKKAVASVSSVATRRGEKSQIQAAERKEPIHCSRGKQLLKKVVHSQECNSVLTNARSWGVTVLYVEDVVSYIERLERPPSRGIQNKTAEGRAADSTRPSLKIARLRSPFIKIEDQSRKFRPLQCTFTSFPELSFVCSDKSPFETVQTVKKKDPGDQEEEEGQRSQKPQARKRKGYCECCEETFDTLSEHLVGEHHFRFVSNPLSYKMIDDLAAQLTCDLMELPFGSPTSPEAERSSQNEDWDLDLAPGEAEPAGNEGHELGILKATRLDKDGHADCEDQGAPAYLRDGGAEEPDQRCGEIPLANIEVDVYNVCSFDQPVVTCTMELPDVSAEGKIHSNLLGSTVGDERVLQRTNGTCEPHIDLALGNGRELKHAELQKDPLTKDSQPELLSTAHEQLPTSAPCMLLEGASVVHFPSHGGTVGSQGDVTSHSAANKPHTENCPVDSTGDRHAQPAGSDALAMSCVIPTLDNGGRHVDATMQSHWEVPLGCTTDTLLSYSTTVTVGELGPEAHNPTPEQQPLLISTCSSITTVCCTDTEFKSCTVSVHSTSHSPPNQNVKSNQTPSLLEMDLANPNCHRAKRKHWDSLLSPPGKKPTSPSHCQSLTLPMWLLCQFPNYGQQVQLPVWADLCKWDGTAAAEEGTVDCSSSSTLPKLHQDSFSSESDWDAHLPSFFQNNPQQSLQCGDLRTAQVTLNESWYGKQLCNILTHDP

DBF4B

Protein DBF4 homolog B

615 amino acids

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle.

67.243 kDa

MSEPGKGDDCLELESSMAESRLRAPDLGVSRCLGKCQKNSPGARKHPFSGKSFYLDLPAGKNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREVKAESSGKSHRGCPSPSPSEVRVETSAMVDPKGSHPRPSRKPVDSVPLSRGKELLQKAIRNQGSISGGGSGGSSSLLTNARSWGVRILHVDEMMMHVQQLSLASLCVKKQQPKKPEGTCPAAESRTRKVARLKAPFLKIEDESRKFRPFHHQFKSFPEISFLGPKDASPFEAPTTLGSMHHTRESKDGEPSPRSAAHTMPRRKKGYCECCQEAFEELHVHLQSAQHRSFALEAHLYAEVDRIIAQLSHSFADIPFQAGLPRWSGSPASDCDPLCPETLHPHQPSHPRAASPRIRKEDSCQASVTQGRAAGQQRWTESLDGVMGPPASHTCVSATTLLPALPKGSREQGCLCPCPASFTQSHLVTSLALLPGEWSPAEDMPLHPSQENSFAPADIPVKGPLLFPEARPWLMSARCWVRPFPFVTWGCLIPHDTTPLHEEVSPCPCLRLGYLYLLLTQSLWCRVRVPSLSTAGPIPRTSHPCTLAFPSYLNDHDLGHLCQAKPQGWNTPQPFLHCGFLAVDSG