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DBF2

Gene
DBF2
Protein
Cell cycle protein kinase DBF2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
710 amino acids
Function
Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Required for proper nuclear segregation, mitotic spindle organization, actomyosin ring contraction, primary septum assembly, and normal hyphal morphogenesis.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
82.356 kDa
Sequence
MTNFFNRSPKHQSHHYQPHQQDVTDISYSMENVSISSNAMMDIDTSYRSSKPTYNNPQQQQQQQQQQQAQNNLFNKENITPLNSPTKSILHNSPQQAKSSTSPQHLYNKLVNANYNGNSPQPGIQQQQNNRALQNNINQLQPPLNKRYKLTEAEFYAKANSARTKRLTSIAQLYFLDYYCDMFDYVINRRERTAIVEKNLLTDPMYKNDITKQQFEWKNYIGRERALLRKRRLKPKHKDFEMITQIGQGGYGQVFLSRKRDTREICALKILNKKLLIKLDETRHVLTERDILTNTRSDWLVKLLYAFQDQEKVFLAMEFVPGGDFRTLLNNTGYLIPPHARFYISEMFAAVNSLHELGFTHRDLKPENFLIDSKGHIKLTDFGLAAGTVCNDRIESMKIKLQNLQNLNDFNDDSNNDNHHYQVPSSLIYERQKIFKQSQQQQQQQNSNNTTANSIVGSPDYMALEVLEGKNYNYTIDYWSLGCMLFEALCGYPPFSGSKQDETYYNLKHWKTALRRPQTKDGRYVFSDRTWNLIIKLIASPNNRLQNFKQVQQQSYFSDIKDWGNLRQKTPPFTPQLDNEEDAGYFDDFEDDEMMMKYKDVFARQEQNEQLLEKSNTTTTTTTTTTTKNGKRFSPGSKFNDNFIGFTFKHKSNPNNKFTNGSGNTGRYGNGNGNNNNNGEINLLNMVENGNGIGNGNSRSSRLNPLATLY

Gene
DBF2
Protein
Cell cycle protein kinase DBF2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
572 amino acids
Function
Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Phosphorylates CHS2 to regulate its dynamics and chitin synthesis at the division site during cytokinesis. Coordinates septin and actomyosin ring (AMR) functions during cytokinesis through the phosphorylation of HOF1. In complex with MOB1, phosphorylates CDC14 at sites adjacent to its nuclear localization sequence, thereby retaining CDC14 in the cytoplasm. Binds also to SWI5 and CLB2 mRNAs cotranscriptionally to regulate their decay. In the nucleus, the DBF2-MOB1 complex regulates passenger protein localization during anaphase. Mediates sorbic acid stress tolerance through promoting vacuolar H(+)-ATPase function, probably through phosphorylation of VMA1 and VMA2 subunits.
Similarity
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Mass
66.148 kDa
Sequence
MLSKSEKNVDLLAGNMSNLSFDGHGTPGGTGLFPNQNITKRRTRPAGINDSPSPVKPSFFPYEDTSNMDIDEVSQPDMDVSNSPKKLPPKFYERATSNKTQRVVSVCKMYFLEHYCDMFDYVISRRQRTKQVLEYLQQQSQLPNSDQIKLNEEWSSYLQREHQVLRKRRLKPKNRDFEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTRCLKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISNERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQLREKEINYANSMVGSPDYMALEVLEGKKYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRRWKQTLRRPRQSDGRAAFSDRTWDLITRLIADPINRLRSFEHVKRMSYFADINFSTLRSMIPPFTPQLDSETDAGYFDDFTSEADMAKYADVFKRQDKLTAMVDDSAVSSKLVGFTFRHRNGKQGSSGILFNGLEHSDPFSTFY