Protein
NAD-dependent protein deacylase
Function
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
Similarity
Belongs to the sirtuin family. Class III subfamily.
Sequence
MSDCLLPSSDMDAFRKILKKANSVVILTGAGVSAESGVPTFRGAGGLWRTYSAQNLATPSAFRSNPSLVWEFYHHRRENMASKSPNNAHNAIAEFEHRMTKEGRHVSVITQNIDELHQRAGSVNVLELHGSLFKTRCLKCKKIEPNHDSPICEALRGKGSPSPNEVGELVPESLLPRCKVSSCGGLLRPHVVWFHENLDSAVLKKADEELNSCDLCLVVGTSSVVYPAAMFAPQVAERGVPVAEFNMETTAATHHFGFHFSGPCGELLPKALAP