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DAAM2

Gene
Daam2
Protein
Disheveled-associated activator of morphogenesis 2
Organism
Mus musculus
Length
1115 amino acids
Function
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822). Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309). During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822). Also regulates non-canonical Wnt signaling pathway (PubMed:24091014). Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014). Together with DAAM1, required for myocardial maturation and sarcomere assembly (PubMed:26526197).
Similarity
Belongs to the formin homology family.
Mass
128.37 kDa
Sequence
MALRKRSPHGLGFLCCFGGSDLPEIDLRDSHPLQYLEFSGPIPNPEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYYIDRINAMAAMQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQAYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVARHNESSTGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPPIPPGAPPCFSSGPPPSHDPFSSNEAPLRKKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIYITSRKVKELSVIDGRRAQNCIILLSKLKLSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELTLSQRLKQMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALEESGEFDDLVSALRSGEVFDKDLSKFKRNRKRPGSQVPEVTRERAINRLNY

Gene
Daam2
Protein
Disheveled-associated activator of morphogenesis 2
Organism
Mus musculus
Length
1115 amino acids
Function
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822). Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309). During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822). Also regulates non-canonical Wnt signaling pathway (PubMed:24091014). Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014). Together with DAAM1, required for myocardial maturation and sarcomere assembly (PubMed:26526197).
Similarity
Belongs to the formin homology family.
Mass
128.37 kDa
Sequence
MALRKRSPHGLGFLCCFGGSDLPEIDLRDSHPLQYLEFSGPIPNPEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQEDPNKLATSWPEYYIDRINAMAAMQNLYETEDEETDKRNQVVEDLKTALRTQPMRFVTRFIDLEGLTCLLNFLRGMDHTTCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQAYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKHTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVARHNESSTGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPPIPPGAPPCFSSGPPPSHDPFSSNEAPLRKKRIPQPSHPLKSFNWVKLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQRHQACMQEGPQRERGNVRDGGAASRPLPAVEASAHRTEKASRSMVSATGAKKELGSTEDIYITSRKVKELSVIDGRRAQNCIILLSKLKLSNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELTLSQRLKQMLEVVLAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQDLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKVLAGGALEESGEFDDLVSALRSGEVFDKDLSKFKRNRKRPGSQVPEVTRERAINRLNY

Gene
DAAM2
Protein
Disheveled-associated activator of morphogenesis 2
Organism
Gallus gallus
Length
1075 amino acids
Function
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822). Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309). During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822). Also regulates non-canonical Wnt signaling pathway (PubMed:24091014). Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014). Together with DAAM1, required for myocardial maturation and sarcomere assembly (By similarity).
Similarity
Belongs to the formin homology family.
Mass
123.875 kDa
Sequence
MAPRKRNRHALGFLCCFGGSDLPEINLKDNNPLQFLDFTVPIPPTEELNARFSELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQTLYAFDEEETEMKNKIVEDLKTALRTQPMRFVMRFIELDGLSCLLNFLKSMDYETSESRIHTSVIGCIKALMNNSQGRAHVLAHPESINIISQSLRTENIKTKIAVLEILGAVCLVPDGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSMGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLREHENATLDRHLDFFEMVRNEDDLELAKRFDLIHIDTKSASQMFELIKKRLKHTDAYPYLLSILQHCLQMPYKRNGGNFQQWQLLDRILQQIVLQDERGDDPDIAPLENFNVKNIIKMLVNENEVKQWRDQAEKFRKDHAELMSKLEKKERECETKTQEKDEMMKTLNKMKDKLQKESLELRQARDQMNDLVAQLNEYSQGGSISFPAPPPPPPGGPLALSSALSSALTSENLPPLPPPLPFSSCPPPPAPPPPPGGPPPPPGAPPFFSLGVPPPSTTTFSSAGTSLKKKSIPQPSHPLKSFNWAKLSEERIHGTIWNEIDDLKAFKVLDLEDFEKMFSAYQRHQKEMGSTEDLYLSTRKVKELSVIDGRRAQNCVILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFVPEKSDTDLLEEHKHEIERMARADRFLFEMSRIDHYQQRLQALFFKKKFPERLAEAKPKVEAILLASKELIRSKRLRQLLEVVLAFGNYMNKGQRGSAYGFKVSSLNKIADTKSSIDRNITLLHYLIMIFEKNYPDILDIQTELQHLPEAAKVNLVELEKEVNNIKTGLKAVEAELDYQKRRIRESGDRFVPVMSDFITVASFSFSELEDLLNDARDKYAKALKHFGENEGKMQPDEFFGIFDTFLQSFAEAKQDLENMRKKKEEEERRARMEAMLKEQREKERRQKKAKAGSISEETGEFDDLVSALRSGEVFDKDLSKLKRNRKRSGNQGLETSRERVVTKLNY

Gene
DAAM2
Protein
Disheveled-associated activator of morphogenesis 2
Organism
Gallus gallus
Length
1075 amino acids
Function
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system (PubMed:22227309, PubMed:24091014, PubMed:25754822). Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1) (PubMed:22227309, PubMed:25754822). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity (PubMed:22227309). During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A (PubMed:25754822). Also regulates non-canonical Wnt signaling pathway (PubMed:24091014). Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation (PubMed:24091014). Together with DAAM1, required for myocardial maturation and sarcomere assembly (By similarity).
Similarity
Belongs to the formin homology family.
Mass
123.875 kDa
Sequence
MAPRKRNRHALGFLCCFGGSDLPEINLKDNNPLQFLDFTVPIPPTEELNARFSELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQTLYAFDEEETEMKNKIVEDLKTALRTQPMRFVMRFIELDGLSCLLNFLKSMDYETSESRIHTSVIGCIKALMNNSQGRAHVLAHPESINIISQSLRTENIKTKIAVLEILGAVCLVPDGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSMGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLREHENATLDRHLDFFEMVRNEDDLELAKRFDLIHIDTKSASQMFELIKKRLKHTDAYPYLLSILQHCLQMPYKRNGGNFQQWQLLDRILQQIVLQDERGDDPDIAPLENFNVKNIIKMLVNENEVKQWRDQAEKFRKDHAELMSKLEKKERECETKTQEKDEMMKTLNKMKDKLQKESLELRQARDQMNDLVAQLNEYSQGGSISFPAPPPPPPGGPLALSSALSSALTSENLPPLPPPLPFSSCPPPPAPPPPPGGPPPPPGAPPFFSLGVPPPSTTTFSSAGTSLKKKSIPQPSHPLKSFNWAKLSEERIHGTIWNEIDDLKAFKVLDLEDFEKMFSAYQRHQKEMGSTEDLYLSTRKVKELSVIDGRRAQNCVILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFVPEKSDTDLLEEHKHEIERMARADRFLFEMSRIDHYQQRLQALFFKKKFPERLAEAKPKVEAILLASKELIRSKRLRQLLEVVLAFGNYMNKGQRGSAYGFKVSSLNKIADTKSSIDRNITLLHYLIMIFEKNYPDILDIQTELQHLPEAAKVNLVELEKEVNNIKTGLKAVEAELDYQKRRIRESGDRFVPVMSDFITVASFSFSELEDLLNDARDKYAKALKHFGENEGKMQPDEFFGIFDTFLQSFAEAKQDLENMRKKKEEEERRARMEAMLKEQREKERRQKKAKAGSISEETGEFDDLVSALRSGEVFDKDLSKLKRNRKRSGNQGLETSRERVVTKLNY

Gene
DAAM2
Protein
Disheveled-associated activator of morphogenesis 2
Organism
Homo sapiens
Length
1068 amino acids
Function
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.
Similarity
Belongs to the formin homology family.
Mass
123.499 kDa
Sequence
MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY

Gene
DAAM2
Protein
Disheveled-associated activator of morphogenesis 2
Organism
Homo sapiens
Length
1068 amino acids
Function
Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly.
Similarity
Belongs to the formin homology family.
Mass
123.499 kDa
Sequence
MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY