Protein
Cleavage and polyadenylation specificity factor 73
Organism
Drosophila melanogaster
Function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'-end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.
Similarity
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.
Sequence
MTQATGDARMPDEESDLLQIKPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPYVDLIEADEIDLLFISHFHLDHCGALPWFLMKTSFKGRCFMTHATKAIYRWMLSDYIKISNISTEQMLYTEADLEASMEKIETINFHEERDVMGVRFCAYIAGHVLGAAMFMIEIAGIKILYTGDFSRQEDRHLMAAEVPPMKPDVLITESTYGTHIHEKREDRENRFTSLVQKIVQQGGRCLIPVFALGRAQELLLILDEFWSQNPDLHEIPIYYASSLAKKCMAVYQTYINAMNDRIRRQIAVNNPFVFRHISNLKGIDHFEDIGPCVIMASPGMMQSGLSRELFESWCTDPKNGVIIAGYCVEGTLAKAVLSEPEEITTLSGQKLPLNMSVDYISFSAHTDYQQTSEFIRLLKPTHVVLVHGEQNEMSRLKLALQREYEADASTDIKFYNPRNTHAVDLYFRGEKTAKVMGSLAAKNSEVGSKLSGVLVKRDFKYHLLAPSDLGKYTDMSMSVVTQRQSIPWGSSLSTLELLLDRIGAGCVEVLEAERKLRVFGCIELTVEQKIIVMEWQATHVNDVYADAVLACIMQSELGGTNLKGATKQTKSEDSRFRECLIETLQDTFGDNCVPKMFEGDLLPVTVSGKRAEINLETLAISCAEDDVLRQMLNTTVQKLHQTLVSAL