CAP

Adenylyl cyclase-associated protein

481 amino acids

May have a regulatory bifunctional role.

Belongs to the CAP family.

53.144 kDa

MEQLVSRLEAVTNRLEAVASRGGGSTIKAAVDDDPAWFDDFKVFNAKFLSGFVNDTIALGGELEQMGKFVNEAFHCHLVLMEVAARHNRPSQTDLEGLLKPLSEAISKVQDFREKNRSSKQFNHLSAISEGLPFLGWVGVAPKPVLYIQQMEESAQFYTNKLLKEFRESDPKQANWATSFIQLLKGFAAYVKDHHQAGLMWNKEKSAATPAALAVSAHKPPVPPPPSGFAPPPPPPIQAPTVTHAVTGSHSSEDSRSQLFAQLSKGSEVTAGLKKVTDDMKTHKNPELRNQPPLKSSALDPRPYTPPNLKKFSAPVSKPAKKPALFQLQNKKWVIENQDGNTNLEISECNDKQTVYMYKCHASKVHINGKVNSIILDSCEKCVIEFTDVISTFEFTNCKACKVQIDGFAPTISIEKTDGAQVFINPKCLESQIVTAKSSEMNICVMKPDGDLTEYPLPEQFKTVWNPATSKFITTTMDLNL

cap

Adenylyl cyclase-associated protein

464 amino acids

May have a regulatory bifunctional role. Binds G-actin and PIP2. Involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner.

Belongs to the CAP family.

49.641 kDa

MSEATIVELLKRLDQATTRLEAVEKSIASGVASSSSSSSPSSGAAGPSSASVKEFQNLVDQHITPFVALSKKLAPEVGNQVEQLVKAIDAEKALINTASQSKKPSQETLLELIKPLNNFAAEVGKIRDSNRSSKFFNNLSAISESIGFLSWVVVEPTPGPHVAEMRGSAEFYTNRILKEFKGVNQDQVDWVSNYVNFLKDLEKYIKQYHTTGLTWNPKGGDAKSATPAPASSAPAAPVAPAVSSTPVESKKGPGLGAVFGELSKGDGVTSGLKKVTNDMKSKNFTDKSSVVKAADTKVAKVDAPSRPAVFALQGNKWSIEYQVNNKEIVIAEPDSRQTVYIFQCVNSLVQIKGKVNAITLDGCKKTSIVFENAISSCEVVNCNGVEIQVTGRVPSIAIDKTSGCQIYLSKDSLETEIVSSKSSEMNVLIPGATENDDLVELAIPEQYKTSVKGNKLHTESTSHI

Cap

Probable capsid protein

273 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the circoviridae capsid protein family.

31.96 kDa

MRRRRFRRRRAPIRRRRIRRRRTRLSRNIRGHRRSSRIYYFRLRRKDKITLTQATNDFKFGTGIFTFKLADVLTVGLNAPTLKVPFEDYQIALVKVEMRPLGVDITTWKGFGHTVPMYDARLKTFQGQVDLGDDPLMDFDGARKWDLRKGFKRLIRPRPQLTIADLATANQSAATWFSGRNQWIPLQVSGNSLFPQKVNHYGLAFSYLQPQPDPMYYECEVTFYVKFRQFAWTTLNVPPTPNIEGMELMHICNGDCNQCFADALDPDSAVDSE

Cap

Probable capsid protein

250 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the circoviridae capsid protein family.

29.046 kDa

MPLYRARPRSLYSRRRRATNRRRRYRRRRLHIGRIRSKYTIFNVKQTQNISFTFFGTGSPDKNKWQAMSLEAVQSSGTSPKPGINLRFAVFGDRLPGTGNQYHYPFDYYMIRMVKVELRPAFNPFQRVRTQGSTYIDKEGNITTTTSGGEWNVDPYAAMSSRKTWSPHRYHKRVFVPKPTIQQGGTGTNIWSTWYTPGGRQLWLNSIQDNVVFYGMGMSLRQAEDTAAPLTVEATITYYIRFGQWTGLSP

Cap

Probable capsid protein

250 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the circoviridae capsid protein family.

29.994 kDa

MWLTFNQVARRRRPLAPRRRRWRRRYWXRRRRIPANRRGHRTNRVYRFRFVREFGQVLQKGTGGSQLSFGTDGINIILDDFLDWGTINWRLPFEDYRIRLAKVEMRPLNESWEEWKGFGHNVPIQDNHLEDFFKKTRLDADPLANWDGARKWDLRKGFKRLFKPRPQLSVTDTDAANVTAALWLNNPKSLWIPIMKKSDQNLPSSGTRVKHYGLAFSWPEPTPNQMDYQVKVTIYCEFRQMNLTHLATPK

Cap

Capsid protein

247 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope.

Belongs to the circoviridae capsid protein family.

28.942 kDa

MWGTSNCACAKFQIRRRYARPYRRRHIRRYRRRRRHFRRRRFTTNRVYTLRLTRQFQFKIQKQTTSVGNLIFNADYITFALDDFLQAVPNPHALNFEDYRIKLAKMEMRPTGGHYTVQSNGFGHTAVIQDSRITKFKTTADQTQDPLAPFDGAKKWFVSRGFKRLLRPKPQITIEDLTTANQSAALWLNSARTGWIPLQGGPNSAGTKVRHYGIAFSFPQPEQTITYVTKLTLYVQFRQFAPNNPST

Cap

Capsid protein

233 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17 - 22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is internalized in a clathrin-, caveolae- and dynamin-independent, actin and Rho-GTPase-mediated pathway and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope (By similarity).

Belongs to the circoviridae capsid protein family.

27.897 kDa

MTYPRRRYRRRRHRPRSHLGQILRRRPWLVHPRHRYRWRRKNGIFNTRLSRTFGYTVKATTVRTPSWAVDMMRFNIDDFVPPGGGTNKISIPFEYYRIRKVKVEFWPCSPITQGDRGVGSTAVILDDNFVTKATALTYDPYVNYSSRHTIPQPFSYHSRYFTPKPVLDSTIDYFQPNNKRTQLWLRLQTSRNVDHVGLGTAFENSIYDQDYNIRVTMYVQFREFNLKDPPLKP

Cap

Capsid protein

230 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17-22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope.

Belongs to the circoviridae capsid protein family.

27.479 kDa

MTWPRRRYRRRRTRPRSHLGNILRRRPYLAHPAFRNRYRWRRKTGIFNSRLSTELVLTIKGGYSQPSWNVNYLKFNIGQFLPPSGGTNPLPLPFQYYRIRKAKYEFYPRDPITSNERGVGSTVVILDANFVTPSTNLAYDPYINYSSRHTIRQPFTYHSRYFTPKPELDQTIDWFHPNNKRNQLWLHLNTHTNVEHTGLGYALQNAATAQNYVVRLTIYVQFREFILKDP

Cap

Capsid protein

219 amino acids

Self-assembles to form the virion icosahedral capsid with a T=1 symmetry. This very small capsid (17-22 nm in diameter) allows the virus to be very stable in the environment and resistant to some disinfectants, including detergents. Essential for the initial attachment to heparan sulfate moities and chondroitin sulfate B of the host cell surface proteoglycans. After attachment, the virus is endocytosed and traffics to the nucleus. The capsid protein binds and transports the viral genome and Rep across the nuclear envelope.

Belongs to the circoviridae capsid protein family.

25.006 kDa

MPFSRRRRVVRRRKPVRRLRRRRRRFFKRAGRGSFRVKLTRFVSITQDISKTTQFSFEITPSDFTEFATLADAFEAVRFTRAKVTVLPQQNVSNNSTSLIPAYCMFPWHKELPTVATFNGFLSIDRAKCFRGTQVGIQHYVPSTLDSIQTKGAAGYEVQSVQTKYKPTIQISGGASTVVLYTGALGMQALSDAPENAQAHYNIKIDMWCTFINQTSFNK