Protein
D-galactonate dehydratase family member Caci_4410
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Function
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
Similarity
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Sequence
MTDANHLLDPSGALPQTRPPWTSRDSLRITRVRAIVTAPEGQPLVVVRVDTSDDGLYGLGCATFTQRYAAVAAAVDEHVGPLAVGRHPADIEDITRLIHYSSYWRSGPVLNNALSGLDQALWDIAGKRAGMPVYELLGGRSRSAVEVYSHAAGGTIEATLDQAEELLAEGYRNVRLQLGGPGLGTYGAPGTLGGYPRSPHPDGWAVEQYLRDAPRLFAAARERLGDSVNLMHDVHSRLTPKQAVVLARALEPYRLSFLEDVIAPELYDRLPEVRAASPVPIAVGEQIGSVPDAVRLVRDGGVDLLRLHTSAVGGLTPTRKIVALCELLGVRTAFHSPADVSPVGVAANLAVDISTPAFGYQESHTYNDATHEVFPGTRVVREGHLYPAEEPGWGIEIDERAAAKFPPVKFLHERWSSGVRRPDGGLEAP