CYPA

Gene

cypA

Protein

Cytochrome P450

Organism

Bacillus subtilis (strain 168)

Length

410 amino acids

Similarity

Belongs to the cytochrome P450 family.

Mass

47.385 kDa

Sequence

MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSLGALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPPDHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVISEMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGDLISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQQPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIFPNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQMKWKGNFLMRALEELPISF

Protein

Cytochrome P450: cypA

Gene

CYPA

Protein

Peptidyl-prolyl cis-trans isomerase

Organism

Blattella germanica

Length

164 amino acids

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Similarity

Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.

Mass

17.935 kDa

Sequence

MAHPRVFFDMSADGQPVGRIVMELRSDVVPKTAENFRALCTGEKGFGYKGSRFHRVIPNFMCQGGDFTNHNGTGGKSIYGTKFEDENFQLKHTGPGILWMANAGPNTNGSQFFITTAKTSWLDNRHVVFGSVVEGMDVVKKLESLGSQSGKTNKKIAVVDCGQI

Protein

Peptidyl-prolyl cis-trans isomerase: CYPA

Gene

cypA

Protein

Cypemycin

Organism

Streptomyces sp

Length

64 amino acids

Function

Antibiotic peptide structurally related to lantibiotics. Active against M.luteus (MIC=0.2 ug/ml). Has cytotoxic activity against mouse P388 leukemia cells (IC(50)=1.3 ug/ml).

Similarity

Belongs to the linaridin family.

Mass

6.533 kDa

Sequence

MRSEMTLTSTNSAEALAAQDFANTVLSAAAPGFHADCETPAMATPATPTVAQFVIQGSTICLVC