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CYP76B1

Gene
CYP76B1
Protein
7-ethoxycoumarin O-deethylase
Organism
Helianthus tuberosus
Length
490 amino acids
Function
Capable of dealkylating a model xenobiotic compound, 7-ethoxycoumarin. Metabolizes with high efficiency a wide range of xenobiotics, including alkoxycoumarins, alkoxyresorufins, and several herbicides of the class of phenylureas. Catalyzes the double N-dealkylation (oxidative N-demethylation) of phenylureas such as chlortoluron and isoproturon with turnover rates comparable to those reported for physiological substrates and produces non-phytotoxic compounds. Could be used for control of herbicide tolerance and selectivity, as well as soil and groundwater bioremediation.
Similarity
Belongs to the cytochrome P450 family.
Mass
54.991 kDa
Sequence
MDFLIIVSTLLLSYILIWVLGVGKPKNLPPGPTRLPIIGNLHLLGALPHQSLAKLAKIHGPIMSLQLGQITTLVISSATAAEEVLKKQDLAFSTRNVPDAVRAYNHERHSISFLHVCTEWRTLRRIVSSNIFSNSSLEAKQHLRSKKVEELIAYCRKAALSNENVHIGRAAFRTSLNLLSNTIFSKDLTDPYEDSGKEFREVITNIMVDSAKTNLVDVFPVLKKIDPQGIKRGMARHFSKVLGIFDQLIEERMRTGRFEQGDVLDVCLKMMQDNPNEFNHTNIKALFLDLFVAGTDTTSITIEWAMTELLRKPHIMSKAKEELEKVIGKGSIVKEDDVLRLPYLSCIVKEVLRLHPPSPLLLPRKVVTQVELSGYTIPAGTLVFVNAWAIGRDPTVWDDSLEFKPQRFLESRLDVRGHDFDLIPFGAGRRICPGIPLATRMVPIMLGSLLNNFDWKIDTKVPYDVLDMTEKNGTTISKAKPLCVVPIPLN