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CYP71AJ4

Gene
CYP71AJ4
Protein
Angelicin synthase
Organism
Pastinaca sativa
Length
478 amino acids
Function
Involved in angular furanocumarin biosynthesis. Converts (+)-columbianetin to angelicin. Produces also some hydroxycolumbianetin as a by-product. No activity with demethylsuberosin, (+)-marmesin, 5-hydroxymarmesin, psoralen, bergaptol, xanthotoxol, bergapten, xanthotoxin, isopimpinellin, cinnamic acid, 4-coumaric acid, 2-coumaric acid, ferulic acid, coumarin, herniarin, scopoletin, or umbelliferone. The reaction mechanism is initiated by the abstraction of syn-C-3'-hydrogen.
Similarity
Belongs to the cytochrome P450 family.
Mass
54.135 kDa
Fragment
single
Sequence
YFFSLFLVTIFLYKWLAKKTPSKNLPPSPPRLPIIGNLHQIGPDLHISLRDLARKYGPLMQLQLGRIPVLVVSSAEATREVLKTHDVVFSQRPITSAIDKLCYKGRDVAFSRYSEYWRQVRSTCVTQLLSNSRVHSFHNIREEEVALLIQNIENSASEVINLGEQLIQLTRNVVCRVSVGSEYLSGHKGKLYQKLLAEVTEMLAYTYSIGDFIPLLGWVDWLSGSKAKVEKTAKEVDAFLEGALRDHIKTMASNKGSANDDFLSILLEIREADAGSTLDEECIKAIVWDMILGGTETTSTTLEWIVAAIIKNPDVMFKLQKEVREIGKGKSKIEEVDLVKMNYLKAVMKESMRLYITAFLLPREAKQDVKLMGYDISSGTQVLINTWETARDPSLWDNPEEFRPERFLNSPIDYKGLHYEYLPFGGGRRGCPGIQFAMAVNELAVANVVYKFDFKMPDGERFEDLDMSGVPGISLYRK