Protein
Cytochrome P450 2F3
Function
Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Stereoselectively catalyzes the formation of the 1R,2S-oxide from naphthalene. Lack activity with other common P450 substrates including 7-ethoxycoumarin.
Similarity
Belongs to the cytochrome P450 family.
Sequence
MDSISTAILLLILALICLLLTTSSKGKGRLPPGPRALPFLGNLLQLRSQDMLTSLTKLSKEFGAVYTVYLGPRRVVVLSGYQAVKEALVDQAEEFSGRGDYPAFFNFTKGNGIAFSNGDRWKALRKYSLQILRNFGMGKRTIEERILEEGHFLLEELRKTQGKPFDPTFVVSRSVSNIICSVIFGSRFDYDDDRLLTIIHLINENFQIMSSPWGEMYNIFPNLLDWVPGPHRRLFKNYGRMKNLIARSVREHQASLDPNSPRDFIDCFLTKMAQEKQDPLSHFFMDTLLMTTHNLLFGGTETVGTTLRHAFRLLMKYPEVQVRVQEEIDRVVGRERLPTVEDRAEMPYTDAVIHEVQRFADIIPMSLPHRVTRDTNFRGFTIPRGTDVITLLNTVHYDPSQFLKPKEFNPEHFLDANMSFKKSPAFMPFSAGRRLCLGEALARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNVPRPYQLCVRAR