CYP21

Gene

CYP21

Protein

Steroid 21-hydroxylase

Organism

Bos taurus

Length

496 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

56.077 kDa

Sequence

MVLAGLLLLLTLLAGAHLLWGRWKLRNLHLPPLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVDQLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLTRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSALAFGCGARVCLGESLARLELFVVLLRLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPRGVEAGAWESASAQ

Protein

Steroid 21-hydroxylase: CYP21

Gene

Cyp21

Protein

Steroid 21-hydroxylase

Organism

Rattus norvegicus

Length

493 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.946 kDa

Sequence

MLLPGLLLLLLLLLLAGTRWLWGQWKLWKLRLPPLAPGFLHFLQPNLPVYLFGLAQKLGPIYRIRLGLQDVVVLNSNKTIEEALIQKWVDFAGRPQILDGKMNFDLSMGDYSLTWKAHKKLSRSALVLGMRDSMEPLVEQLTQEFCERMRAQAGASVAIHKEFSLLTCSIISCLTFGDKQDSTLLNATHSCVRDLLKAWNHWSVQILDIIPFLRFFPNPGLWKLKQFQESRDHIVMQELKRHKDSLVAGQWKDMIDYMLQGVEKQRDARDPGQLHERHVHMSVVDLFVGGTETTAATLSWAVAFLLHHPEIQKRLQEELDLKLAPSSQLLYKNRMQLPLLMATIAEVLRLRPVVPMALPHRATKASSISGYDIPKDTIIIPNIQGANLDEMVWELPSKFWPDRFLESGKSPRIPTFGCGARVCLGEPLARLEFFVVLARLLQTFTLLPPPDGTLPSLQPLPYTGINLLIPPFQVRLQPRNLAPQDQGQKSSTG

Protein

Steroid 21-hydroxylase: Cyp21

Gene

CYP21

Protein

Steroid 21-hydroxylase

Organism

Canis lupus familiaris

Length

492 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.366 kDa

Sequence

MLLLGVLLLTVLAGARLLWGKWKLRGLHLPPLVPGCLHLLQPDLPLHLLGLTQKLGPIYRLRLGLQDVVVLNSKRTIEEAMVRKWVDFAGRPQTPSYKLVSLHHQDLSLGDYSLLWKAHKKLTRSALLLGIRSSMEPLVEQLTQEFCERMRAQAGTPVAIQKEFSLLTCAIICHLTFGDKEDTLVHTFHDCVQDLMRTWEHWSIQMLDIIPFLRFFPNPGLWRLKRALENRDHIVEKQLRQHKESMVAGQWRDMTDYMLQRVGRLRAEEGCGQLLEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQQRLQEELDRELGPGASGSRIPYRDPTRLPLLSATVAEVLRLRPVVPLALPHCTTRPSSISGYDIPEGMVVIPNLQGAHLDETVWERPQEFRPDRFLVPGASPRVLAFGCGARVCLGEPLARLELLVVLAQLLRAFTLMPAAGTLPSLRPRARCGVNLSMQPFQVQLQPRGAGVLGRGQHP

Protein

Steroid 21-hydroxylase: CYP21

Gene

CYP21

Protein

Steroid 21-hydroxylase

Organism

Canis lupus

Length

492 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.366 kDa

Sequence

Protein

Steroid 21-hydroxylase: CYP21

Gene

CYP21

Protein

Steroid 21-hydroxylase

Organism

Felis catus

Length

492 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.476 kDa

Sequence

MLLLGLLLLTALAGARLLWNKWKYRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKLGPVYRLRLGLQDVVVLNSKRTIEEALIRRWVDFAGRPQMPSYKLVSQHYQDLSLGDYSLLWKAHKKLTRSALLLGIRNSMEPLVEQLTQEFCERMRAQAGTPVAIQKEFSFLTCSVICCLTFGDKEDTLVHAFHDCVEDLMKSWEHWSIQVLDIVPFLRFFPNPGLRRLKQALENRDRIVEKQLRQHKDSMVAGQWRDMTDYMLQGMGKPKVEKGHGRLLEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQQRLQEELDCELGPGASGSRVPLKDPSRLPLLTATIAEVLRLRPVVPLALPHRTTRHSSILGYDIPEGTVVIPNLQGAHLDDTVWEQPHEFRPDRFLVPGASPRVLAFGCGARVCLGEPLARLELFVVLARLLHAFTLLPPTGPLPSLRPRSHCGINLTMQPFQVRLQPRGAVAPGPSQHQ

Protein

Steroid 21-hydroxylase: CYP21

Gene

CYP21

Protein

Steroid 21-hydroxylase

Organism

Lynx lynx

Length

492 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.397 kDa

Sequence

MLLLGLLLLTALAGARLLWNKWKYRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKLGPVYRLRLGLQDVVVLNSKRTIEEAMIRRWVDFAGRPQMPSYKLVSQPYQDLSLGDYSLLWKAHKKLTRSALLLGIRNSMEPLVEQLTQEFCERMRAQAGTPVAIQKEFSFLTCSVICCLTFGDKEDTLVHAFHDCVQDLMKSWEHWSIQVLDIVPFLRFFPNPGLQRLKQALENRDRIVEKQLRQHKDSMVAGQWRDMTDYMLQGMGKPRAEKGHGRLLEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQQRLQEELDCELGPGASGSRVPLKDPSRLPLLTATIAEVLRLRPVVPLALPHRTTRHSSILGYDIPEGTVVIPNLQGAHLDDTVWEQPHEFRPDRFLVPGASPRVLAFGCGARVCLGEPLARLELFVVLARLLHAFTLLPPTGPLPSLRPRSHCGINLTMQPFQVQLQPRGAVAPGPSQHQ

Protein

Steroid 21-hydroxylase: CYP21

Gene

CYP21

Protein

Steroid 21-hydroxylase

Organism

Sus scrofa

Length

492 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.62 kDa

Sequence

MVLVWLLLLLTLLAGARLLWGQWKLRNLHLPPLVPGFLHLLQPNLPIYLLGLTQRLGPIYRLRLGLQDVVVLNSKRTIEEALVRKWVDFAGRPQIPSYKLASQHCPDISLGDYSLFWKAHKKLTRSALLLGVRSSMEPRVEQLTQEFCERMRAQAGTPVTIQKEFSVLTCSIICCLTFGDKEDTLVHALHDCVQDLMKTWEHWSIQILDMVPFLRFFPSPGLRRLKQAIENRDHLVEKQLRRHKESMVAGQWRDMLDYMLQEAGRQRVEEGQGQLLEGHVHMSVVDLFIGGTETTANTLSWAVVYLLHHPEIQWRLQEELDRELGPGAAGSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRATRPSSIFGYDIPEGTVVIPNLQGAHLDETVWEQPHEFRPDRFLAPGANPSALAFGCGARVCLGEPLARLELFVVLVQLLQAFTLLPPEGALPSLQPHPHSGINLKVQPFQVRLQPRGGRGEGPGPR

Protein

Steroid 21-hydroxylase: CYP21

Gene

Cyp21

Protein

Steroid 21-hydroxylase

Organism

Mus musculus

Length

487 amino acids

Function

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.

Similarity

Belongs to the cytochrome P450 family.

Mass

55.328 kDa

Sequence

MLLPGLLLLLLLLAGTRWLWGQWKLRKLHLPPLAPGFLHFLQPNLPIYLLGLTQKLGPIYRIRLGMQDVVVLNSNRTIEEALIQKWVDFAGRPHMLNGKMDLDLSLGDYSLMWKAHKKLSRSALMLGMRDSMEPLIEQLTQEFCERMRAQAGTPVAIHKEFSFLTCSIISCLTFGDKDSTLVQTLHDCVQDLLQAWNHWSIQILTIIPLLRFLPNPGLQKLKQIQESRDHIVKQQLKQHKDSLVAGQWKDMIDYMLQGVEKQRDGKDEERLHEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQKRLQEELDLKLGPGSQLLYRNRMQLPLLMATIAEVLRLRPVVPLALPHRATRASSISGYDIPKDMVIIPNIQGANLDEMVWELPSKFWPDRFLEPGKNPRTPSFGCGARVCLGEPLARLELFVVLARLLQAFTLLPPPDGTLPSLQPQPYAGINLPIPPFQVRLQPRNLAPQDQGERP

Protein

Steroid 21-hydroxylase: Cyp21